Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 10, Pages 1198-1202Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1323212
Keywords
Salvianolic acid; Salvia miltiorrhiza; new compound; antibacterial agents; potentiation; MRSA; Acinetobacter baumanii
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The study explored the isolation and characterisation of three compounds of high purity salvianolic acid B freeze-dried powder extracted from Salvia miltiorrhiza Bunge. A new salvianolic acid, salvianolic acid V (2) together with two known compounds (3-4) was identified. The antibacterial activity tests showed that compound 2 combined with clinical antibiotics such as Levofloxacin or Colistin sulphate together exhibited potent effects against MRSA or Acinetobacter baumanii. This report has considerably extended our knowledge about the diversity and bioactivity of caffeic acid derivatives from S. miltiorrhiza. [GRAPHICS] .
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