Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 23, Pages 2810-2813Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1295238
Keywords
Aloe; asphodelaceae; anthraquinone; antioxidant; anti-osteoporosis
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Funding
- Priority Research Center Program through the National Research Foundation of Korea (NRF) [2009-0093815]
- Ministry of Education, Science and Technology (MEST), Republic of Korea [K16281]
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In this study, 25 known anthraquinones and related compounds were isolated from aqueous dissolved Aloe exudates. The antioxidant and anti-osteoporotic activities of the isolated compounds were then investigated. Compounds 8, 11, 20, and 23 showed good antioxidant activity based on peroxyl radical-scavenging and reducing capacity assays at a concentration of 10.0 mu M. Additionally, compounds 7, 9, 15-16, 18, 21-22 and 24-25 showed potent peroxyl radical-scavenging activities with values ranging from 5.28 to 14.60 at 10.0 mu M. Moreover, compounds 8, 11, 15, 20 and 22 exhibited significantly suppressed tartrate-resistant acid phosphatase (TRAP) activity in nuclear factor-kappa B ligand-activated osteoclastic RAW 264.7 cells, with values of 125.67, 118.54, 127.64, 125.82 and 124.98%, respectively. These results indicate that Aloe is an excellent source of antioxidant and anti-osteoporotic phytochemicals. [GRAPHICS] .
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