Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 5, Pages 600-604Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1326489
Keywords
Antiparasitic; halophytes; Inula chritmoides; Leishmania infantum; neglected tropical diseases; Spergularia rubra; visceral leishmaniasis
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Funding
- Foundation for Science and Technology (FCT)
- Portuguese National Budget [XtremeBio: PTDC/MAR-EST/4346/2012, CCMAR/Multi/04326]
- FCT [IF/00049/2012, SFRH/BD/94407/2013, SFRH/BPD/86071/2012, UID/Multi/00612/2013]
- Programa Brasil Sem Miseria / Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)/FIOCRUZ
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This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by high-performance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress. [GRAPHICS] .
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