Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 11, Pages 1260-1266Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1342086
Keywords
Cladosporium sp; gorgonian Dichotella gemmacea; 3-OH pregnane; structure elucidation; antiviral activity
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Funding
- National Natural Science Foundation of China [U1406402, 81172977]
- Taishan Scholars Program, China
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A new pregnane, 3-hydroxy-7-ene-6,20-dione (1), and five known steroids (2-6), along with one known steroidal glycoside (7) were obtained from the fungus Cladosporium sp. WZ-2008-0042 cultured from a gorgonian Dichotella gemmacea collected from the South China Sea. The structure and absolute configuration of the new compound (1) were elucidated by comprehensive spectroscopic data and X-ray diffraction data. The compound has a rare configuration of 3-OH that is different from most of pregnanes. All of the isolated compounds were evaluated for their antiviral activities against respiratory syncytial virus (RSV). Among them, 1 exhibited potential antiviral activity with the IC50 value of 0.12mM. [GRAPHICS]
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