Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 24, Pages 2836-2841Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1300796
Keywords
Eriobotrya japonica; triterpenoid; PDE4 inhibitors
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Funding
- National Natural Science Foundation of China [21402243, 81373258]
- Guangdong Science Foundation [2014A020210009]
- Science Foundation of Guangzhou City [2014J4100165]
- Science and Technology Foundation of Guangzhou City [201607010293]
- Fundamental Research Funds for the Central Universities (Sun Yatsen University) [13ykpy10]
- Medical Scientific Research Foundation of Guangdong Province [B2014105]
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The ethanolic extract of the leaves of Eriobotrya japonica exhibited inhibitory activity against phosphodiesterase-4D (PDE4D), which is a therapeutic target of inflammatory disease. Subsequent bioassay-guided fractionation led to the isolation of a new triterpene (1), together with seven known triterpenoids, methyl corosolate (2), ursolic acid (3), oleanolic acid (4), methyl maslinate (5), -amyin (6), 3,19,23-trihydroxy-urs-12-ene (7) and uvaol (8). The structure of compound 1 was established as 3-hydroxyl-21-acetoxyl-urs-12-en-28-carboxylate on the basis of interpretation of its 1D and 2D NMR and HR-ESI-MS spectroscopic data. The bioassay results verified compounds 2, 3 and 8 inhibited PDE4D2 effectively with the IC50 values of 3.06, 2.18 and 5.17M, respectively, which may provide a novel mechanism for the anti-inflammatory activity of the leaves of E.japonica. [GRAPHICS]
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