What can nanosafety learn from drug development? The feasibility of “safety by design”

Impact of cerium oxide nanoparticles shape on their in vitro cellular toxicity

(2017) Valérie Forest et al.   TOXICOLOGY IN VITRO

Aquatic Ecotoxicity Testing of Nanoparticles-The Quest To Disclose Nanoparticle Effects

(2016) Lars Michael Skjolding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alternative Testing Strategies for Nanomaterials: State of the Science and Considerations for Risk Analysis

(2016) J. A. Shatkin et al.   RISK ANALYSIS

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

(2016) Tu C. Le et al.   Small

Silica nanoparticle-generated ROS as a predictor of cellular toxicity: mechanistic insights and safety by design

(2016) Sean E. Lehman et al.   Environmental Science-Nano

The applicability of chemical alternatives assessment for engineered nanomaterials

(2016) Rune Hjorth et al.   Integrated Environmental Assessment and Management

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

(2015) Sebastian Polak et al.   AAPS Journal

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making

(2015) Donna M. Dambach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Perspectives on the design of safer nanomaterials and manufacturing processes

(2015) Charles Geraci et al.   JOURNAL OF NANOPARTICLE RESEARCH

Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms

(2015) Gerrit Frommeyer et al.   Nature Reviews Cardiology

Research strategy to determine when novel nanohybrids pose unique environmental risks

(2015) Navid B. Saleh et al.   Environmental Science-Nano

DPSIR and Stakeholder Analysis of the Use of Nanosilver

(2015) Steffen Foss Hansen et al.   NanoEthics

A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells

(2014) Dania Movia et al.   BIOMATERIALS

A strategy for grouping of nanomaterials based on key physico-chemical descriptors as a basis for safer-by-design NMs

(2014) Iseult Lynch et al.   Nano Today

Nano(Q)SAR: Challenges, pitfalls and perspectives

(2014) Ratna Tantra et al.   Nanotoxicology

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Microarrays for identifying binding sites and probing structure of RNAs

(2014) Ryszard Kierzek et al.   NUCLEIC ACIDS RESEARCH

Engineering safer-by-design silica-coated ZnO nanorods with reduced DNA damage potential

(2014) Georgios A. Sotiriou et al.   Environmental Science-Nano

Early identification of hERG liability in drug discovery programs by automated patch clamp

(2014) Timm Danker et al.   Frontiers in Pharmacology

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Dealing with Global Safety Issues

(2013) Norman Stockbridge et al.   DRUG SAFETY

Drug safety testing paradigm, current progress and future challenges: an overview

(2013) Varun Ahuja et al.   JOURNAL OF APPLIED TOXICOLOGY

Nanosafety: towards safer design of nanomedicines

(2013) B. Fadeel   JOURNAL OF INTERNAL MEDICINE

Oxidative stress induced by inorganic nanoparticles in bacteria and aquatic microalgae – state of the art and knowledge gaps

(2013) Nadia von Moos et al.   Nanotoxicology

A rule for designing safer nanomaterials: do not interfere with the cellular redox equilibrium

(2013) Enrico Burello et al.   Nanotoxicology

Toward the Development of Decision Supporting Tools That Can Be Used for Safe Production and Use of Nanomaterials

(2012) Claudia Som et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

(2012) Helinor Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Drug discovery: Chemical beauty contest

(2012) Paul Leeson   NATURE

Operationalization and application of “early warning signs” to screen nanomaterials for harmful properties

(2012) Steffen Foss Hansen et al.   Environmental Science-Processes & Impacts

Systematic Evaluation of Nanomaterial Toxicity: Utility of Standardized Materials and Rapid Assays

(2011) Stacey L. Harper et al.   ACS Nano

Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos

(2011) Tian Xia et al.   ACS Nano

No time to lose—high throughput screening to assess nanomaterial safety

(2011) R. Damoiseaux et al.   Nanoscale

Pesticide Exposure, Safety Issues, and Risk Assessment Indicators

(2011) Christos A. Damalas et al.   International Journal of Environmental Research and Public Health

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design

(2010) Ken Donaldson et al.   Nanomedicine

Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes

(2010) Liang Yan et al.   Nanoscale

Keeping the rhythm: hERG and beyond in cardiovascular safety pharmacology

(2010) Clemens Möller   Expert Review of Clinical Pharmacology

A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials

(2009) Huan Meng et al.   ACS Nano

Nanotechnology and in Situ Remediation: A Review of the Benefits and Potential Risks

(2009) Barbara Karn et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The 5 principles of “Design for Safer Nanotechnology”

(2009) Gregory Morose   JOURNAL OF CLEANER PRODUCTION

Under wraps

(2009) Emily Waltz   NATURE BIOTECHNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

From ecotoxicology to nanoecotoxicology

(2009) Anne Kahru et al.   TOXICOLOGY

Maximizing safe design of engineered nanomaterials: the NIH and NIEHS research perspective

(2009) Sally S. Tinkle   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Beyond Implications and Applications: the Story of ‘Safety by Design’

(2009) Christopher M. Kelty   NanoEthics