Article
Biochemistry & Molecular Biology
Josefa Domenech, Mariana de Britto, Antonia Velazquez, Susana Pastor, Alba Hernandez, Ricard Marcos, Constanza Cortes
Summary: The study assessed the long-term effects of polystyrene nanoparticles on human intestinal cells, showing that PSNPs accumulated in cells over time and induced changes at the ultrastructural and molecular levels. However, minor effects were observed in genotoxicity-related biomarkers, indicating no DNA damage or oxidative stress after long-term exposure to PSNPs.
Article
Marine & Freshwater Biology
Maria Bille Nielsen, Janna Vavra, Annemette Palmqvist, Valery E. Forbes
Summary: The study examined the effects of exposure to un-coated AgNPs or silver nitrate on the benthic deposit-feeding polychaete Capitella teleta. The results showed tolerance towards both AgNPs and AgNO3, with significant effects on reproduction and growth observed after eight weeks. Further investigations into the long-term effects of un-coated AgNPs on sediment-dwelling organisms are needed.
AQUATIC TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Maria Vanesa Taboada-Lopez, Baltazar Hiram Leal-Martinez, Raquel Dominguez-Gonzalez, Pilar Bermejo-Barrera, Pablo Taboada-Antelo, Antonio Moreda-Pineiro
Summary: Titanium dioxide nanoparticles and silver nanoparticles are extensively used in various industries and may unintentionally enter the human gastrointestinal tract through food and water. In vitro digestion studies were conducted to determine the bioaccessibility of these nanoparticles in shellfish, as well as their transport through the gastrointestinal epithelial barrier model.
Article
Environmental Sciences
Alexandra Strassmann, Kees de Hoogh, Martin Roosli, Sarah R. Haile, Alexander Turk, Matthias Bopp, Milo A. Puhan
Summary: This study investigated the associations between short-term air pollution exposure and lung function, finding that nitrogen dioxide and particulate matter were negatively associated with lung function in adults, especially long-term PM2.5 exposure with forced vital capacity. These findings add to the evidence of adverse effects of air pollution on lung function in adults.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Lihua Niu, Jiaxin Hu, Yi Li, Chao Wang, Wenlong Zhang, Qing Hu, Longfei Wang, Huanjun Zhang
Summary: This study investigated the long-term effects of silver nanoparticles (AgNPs) on the structure and function of polymethyl methacrylate (PMMA) microplastic biofilms. The results showed that long-term exposure to AgNPs reduced the stability of bacterial communities on microplastics and cumulatively inhibited nitrogen removal and N2O emissions in eutrophic water.
ENVIRONMENTAL RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Sroisuda Chotimanukul, Junpen Suwimonteerabutr, Mongkol Techakumphu, Theerawat Swangchan-Uthai
Summary: This study investigated the effects of elevated temperature on bovine endometrial cell cultures. The findings suggest that heat exposure can compromise the immune response and prostaglandin synthesis of the endometrium, leading to reduced fertility.
Article
Oncology
Liana C. Arnaud, Thierry Gauthier, Augustin Le Naour, Saleha Hashim, Nathalie Naud, Jerry W. Shay, Fabrice H. Pierre, Elisa Boutet-Robinet, Laurence Huc
Summary: The study found that long-term exposure to food contaminants may have a potential promoting effect on colorectal cancer occurrence and development, affecting cellular mechanisms depending on genetic susceptibility.
Article
Chemistry, Multidisciplinary
Anna A. Antsiferova, Marina Yu. Kopaeva, Vyacheslav N. Kochkin, Pavel K. Kashkarov
Summary: This research investigated the accumulation of silver nanoparticles stabilized with polyvinylpyrrolidone in the organs of mice. The study revealed extremely high silver accumulation in the testes after 120 days, as well as significant accumulation in the lungs and brain.
Article
Electrochemistry
J. Srinivasan, T. D. Weirich, G. A. Marino, A. R. Annerino, J. M. Taylor, P. J. Noell, J. J. M. Griego, R. F. Schaller, C. R. Bryan, J. S. Locke, E. J. Schindelholz
Summary: Experiments exposing ground 304 stainless steel samples to sea salt particles at different relative humidity levels showed that corrosion behavior varied significantly depending on the relative humidity of exposure. The distribution of pit populations, pit shapes, and increase in corrosion damage were all different between 40% RH and 76% RH conditions. These findings suggest that the mechanisms determining long-term corrosion behavior are different for different levels of relative humidity exposure.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Mahmuda Akter, A. K. M. Atique Ullah, Subrata Banik, Md. Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: Green synthesized silver nanoparticles (Ag-NPs) show promising cytotoxic and anticancer effects in different cell lines. The study on autophagy-regulated cytotoxic effect of Ag-NPs against human epithelial colorectal adenocarcinoma cells (Caco-2 cells) found that Ag-NPs induced cell death through NF-kappa B mediated autophagy, oxidative stress, and DNA damage, leading to apoptosis and necrosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Medicinal
Yue Sui, Yue Gu, Yujing Lu, Chenxu Yu, Jie Zheng, Hang Qi
Summary: By encapsulating FX in PVP-coated nanoparticles, the study improved FX stability and delivery into cancer cells, showing pro-oxidative activities. This approach could potentially be a new therapeutic strategy for targeted cancer treatment.
Article
Environmental Sciences
Fabianne Ribeiro, Carlos Pinheiro, Marta Monteiro, Cornelis A. M. Van Gestel, Amadeu M. V. M. Soares, Susana Loureiro
Summary: In this study, the uptake and elimination kinetics of silver nanoparticles in fish were investigated. The results suggest that once fish uptake silver nanoparticles, the elimination process takes a long time, which may have ecological implications for bioaccumulation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Materials Science, Paper & Wood
Zhengxin Ma, Jie Liu, Guixian Shen, Xuejing Zheng, Ying Pei, Keyong Tang
Summary: This study reported the surface modification of microfibrillated cellulose with bio-inspired polydopamine, followed by in-situ growth and immobilization of silver nanoparticles, resulting in nanocomposites with long-term antibacterial activity. The nanocomposites exhibited excellent antibacterial performance against pathogenic bacteria and showed potential applications as coating and filling agents.
Article
Food Science & Technology
Wenya Jiao, Yaxin Sang, Xianghong Wang, Shuo Wang
Summary: This study explored the hypoglycemic mechanism of 6-shogaol from the perspective of glucose uptake, absorption transport, and protection of intestinal barrier function. The findings showed that 6-shogaol effectively inhibits the activity of alpha-glucosidase, reduces glucose uptake, down-regulates the expression of glucose transporters, and promotes the up-regulation of tight junction proteins, protecting the intestinal barrier function and promoting intestinal material absorption.
Article
Environmental Sciences
Anna Mittag, Christian Hoera, Alexander Kaempfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei
Summary: The study found that zinc oxide nanoparticles of different sizes have cellular uptake and toxic effects on human intestinal cells, especially showing cytotoxicity at high concentrations, which can accelerate cell apoptosis and death.
Article
Biotechnology & Applied Microbiology
Giannina Alarcon-Aravena, Erico R. Carmona, Gonzalo Recio-Sanchez, Aixa Gonzalez Ruiz, Josefa Domenech, Ricard Marcos, Karla Garrido
Summary: In this study, Fe(3)O(4)NPs were successfully synthesized using leaf extracts of the Peumo tree. The nanoparticles showed good stability in aqueous suspension and demonstrated the potential to reduce COD levels and lower concentrations of phosphates and nitrates in wastewater.
CURRENT NANOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Irene Barguilla, Josefa Domenech, Laura Rubio, Ricard Marcos, Alba Hernandez
Summary: The widespread presence of plastic waste and its derivatives, micro- and nanoplastics, raises concerns about potential health risks. This study examines the interaction between arsenic and polystyrene nanoplastics (PSNPLs) and their joint effects. The results show that continuous co-exposure to both pollutants enhances DNA damage and aggressive features of cell transformation. This study highlights the importance of considering the long-term effects of emerging contaminants like MNPLs and the behavior of mixtures in risk assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Alena Opattova, Sabine A. S. Langie, Mirta Milic, Andrew Collins, Asgeir Brevik, Erdem Coskun, Maria Dusinska, Isabel Gaivao, Ela Kadioglu, Blanca Laffon, Ricard Marcos, Susana Pastor, Jana Slyskova, Bozena Smolkova, Zsofia Szilagyi, Vanessa Valdiglesias, Pavel Vodicka, Katarina Volkovova, Stefano Bonassi, Roger W. L. Godschalk
Summary: Levels of DNA damage represent the dynamics between damage formation and removal. A study analyzed a pooled database of studies with data on base excision repair (BER) to characterize an individual's ability to recognize and properly remove DNA damage. The study found significant sex differences in BER, with higher levels in women, and a relationship between BER and BMI. Moreover, higher BER activity was associated with lower levels of DNA damage detected by the comet assay. These findings highlight the importance of considering BER as a parallel endpoint in future studies.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Naouale El Yamani, Laura Rubio, Alba Garcia-Rodriguez, Alena Kazimirova, Elise Runden-Pran, Barancokova Magdalena, Ricard Marcos, Maria Dusinska
Summary: This study evaluated the effects of TiO2 nanoparticles on two cell lines. The results showed that cell uptake of nanoparticles did not lead to significant cytotoxicity or DNA damage in short-term exposure. However, longer exposure and higher concentrations resulted in decreased cell growth activity.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Environmental Sciences
Mohamed Alaraby, Doaa Abass, Aliro Villacorta, Alba Hernandez, Ricard Marcos
Summary: This study found that coexposure of silver compounds and polystyrene nanoplastics can alleviate the delayed fly emergence and cellular oxidative stress induced by silver compounds. Polystyrene nanoplastics can transport silver compounds across the intestinal barrier and deliver them into the hemolymph of Drosophila larvae. The antagonistic effect may be attributed to the confinement of silver by polystyrene nanoplastics, reducing its bioavailability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Balasubramanyam Annangi, Aliro Villacorta, Montserrat Lopez-Mesas, Victor Fuentes-Cebrian, Ricard Marcos, Alba Hernandez
Summary: This study found that nanoplastics can be absorbed by human nasal epithelial cells, leading to cellular effects such as oxidative stress, mitochondrial membrane potential loss, and abnormal autophagy pathway. It is the first study to reveal the autophagy pathway as a possible target for adverse effects induced by nanoplastics in nasal epithelial cells. Therefore, this research has significant value for the respiratory risk assessment of nanoplastics.
Article
Environmental Sciences
Alireza Tavakolpournegari, Balasubramanyam Annangi, Aliro Villacorta, Gooya Banaei, Joan Martin, Susana Pastor, Ricard Marcos, Alba Hernandez
Summary: The presence of micro/nanoplastics (MNPLs) in the environment is a concern for both the environment and human health. The toxicological profile of MNPLs can be influenced by their size and the ability of cells to internalize them. In this study, different sizes of polystyrene MNPLs were tested on human hematopoietic cell lines, and it was found that cell type and size can modulate the toxicological profile of MNPLs.
Article
Environmental Sciences
Balasubramanyam Annangi, Aliro Villacorta, Lourdes Vela, Alireza Tavakolpournegari, Ricard Marcos, Alba Hernandez
Summary: In order to investigate the impact of plastic micro/nanoparticles on the human body, lab-made PETNPLs were used in this study. The experiment evaluated cell uptake, reactive oxygen species induction, mitochondrial functionality, and modulation of the autophagy pathway. The results showed that PETNPLs significantly affected cell uptake, increased levels of reactive oxygen species, disrupted mitochondrial membrane potential, and altered the autophagy pathway in human nasal epithelial cells.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Irene Barguilla, Veronique Maguer-Satta, Boris Guyot, Susana Pastor, Ricard Marcos, Alba Hernandez
Summary: One important environmental/health challenge is to determine the potential carcinogenic risk associated with environmental agents/exposures. Long-term trials with rodents are inefficient when testing thousands of agents, so a battery of assays covering most of the hallmarks of the carcinogenesis process is proposed. This structured battery could be useful for in vitro studies using human cell lines to detect potential carcinogenic risks of environmental agents/exposures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Lourdes Vela, Aliro Villacorta, Tom Venus, Irina Estrela-Lopis, Susana Pastor, Alba Garcia-Rodriguez, Laura Rubio, Ricard Marcos, Alba Hernandez
Summary: The presence of plastic waste in the environment is a growing concern due to the degradation of plastic into micro- and nanoplastics (MNPLs). Digestion was found to affect the characteristics of polystyrene nanoplastics (PSNPLs), leading to higher cell uptake but no difference in toxicity except at high exposures. Further analysis should be conducted on other MNPLs with varying sizes and chemical compositions.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Gooya Banaei, Alba Garcia-Rodriguez, Alireza Tavakolpournegari, Juan Martin-Perez, Aliro Villacorta, Ricard Marcos, Alba Hernandez
Summary: This study investigated the release of MNPLs from commercially available teabags and their effects on cellular cultures and a model of the intestinal barrier. The MNPLs were found to be in the nano-range and composed of polylactic acid (PLA-NPLs). They were taken up by cells, particularly mucus-secretor cells, and persisted in the tissue after exposure. Although no significant cytotoxicity was observed, there was evidence of slight barrier disruption. This study provides new insights into the safety and behavior of polymer-based teabags in the human body.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Mohamed Alaraby, Aliro Villacorta, Doaa Abass, Alba Hernandez, Ricard Marcos
Summary: Micro and nanoplastics (MNPLs), resulting from plastic waste degradation, are emerging environmental pollutants with potential risks to human health. This study used titanium-doped PET NPLs as a true-to-life model and found that they induced oxidative stress and genotoxicity in a Drosophila model.
ENVIRONMENTAL POLLUTION
(2024)
Article
Biochemistry & Molecular Biology
Irene Barguilla, Vicente Candela-Noguera, Patrick Oliver, Balasubramanyam Annangi, Paula Diez, Elena Aznar, Ramon Martinez-Manez, Ricard Marcos, Alba Hernandez, Maria Dolores Marcos
Summary: This study evaluated the genotoxicity and transforming ability of different functionalized mesoporous silica nanoparticles on human lung epithelial cells. The results showed that functionalized mesoporous silica nanoparticles induced some measurable adverse effects associated with tumorigenesis, but the toxicity was lower compared to other nanomaterials and certain drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Burcin Yalcin, Merve Gunes, Aysen Yagmur Kursun, Nuray Kaya, Ricard Marcos, Bulent Kaya
Summary: The use of metal oxide nanoparticles can lead to increased exposure and potential genotoxic risks. In this study, the genotoxic effects of cerium oxide (CeO(2)NPs) and magnesium oxide (MgONPs) nanoparticles were evaluated using Drosophila as an in vivo assay model. The results showed that CeO(2)NPs did not increase the frequency of mutations in the wing-spot assay, while MgONPs induced mutations at the highest dose. Moreover, CeO(2)NPs exposure increased the expression levels of Mlh1 and Brca2 genes involved in double-strand break repair, while decreasing the expression levels of MCPH1 and Rad51D genes. MgONPs exposure increased the expression levels of Ercc1, Brca2, Rad1, mu2, and stg genes, while decreasing Mlh1 and MCPH1 gene expression levels. This study demonstrates the usefulness of evaluating changes in gene expression levels to detect mild genotoxic effects.
Article
Chemistry, Multidisciplinary
Mohamed Alaraby, Doaa Abass, Josefa Domenech, Alba Hernandez, Ricard Marcos
Summary: Both primary and secondary micro- and nanoplastics (MNPLs) contribute to the emergence of pollutants in the environment. The potential biological effects of plastics on human health, as well as the association between these effects and MNPL size, need to be thoroughly understood. Using a Drosophila larvae model, this study investigated the journey and interactions of three nanopolystyrene plastics of different sizes (50, 200, and 500 nm) after ingestion, as well as their effects on gene expression, ROS production, and DNA damage. The results showed a size-dependent molecular response, with smaller MNPLs inducing higher responses.
ENVIRONMENTAL SCIENCE-NANO
(2022)