Article
Biotechnology & Applied Microbiology
Qianru Li, Qianqian Liu, Heli Li, Liyun Dong, Yajie Zhou, Jintao Zhu, Liu Yang, Juan Tao
Summary: Nanomedicine has shown great potential in cancer immunotherapy, but there are still limitations in nanoparticle-based immunotherapy. In this study, researchers discovered that encapsulating a photosensitizer in nanoparticles can achieve synergy between photodynamic therapy and immunotherapy. Through experiments, they demonstrated the significant effectiveness of this nanotherapeutic system in inducing antitumor immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Kaili Wang, Junya Lu, Jiali Li, Yinlu Gao, Yuling Mao, Qinfu Zhao, Siling Wang
Summary: Photoactivated therapeutic strategies such as photothermal therapy and photodynamic therapy have become prevalent for fighting tumors, with mesoporous silica nanoparticles showing promise for multimodal cancer therapy. However, challenges remain in the application of these therapies for deep-seated tumors.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Yimin Zhou, Cong Chang, Zuhao Liu, Qiuling Zhao, Qingni Xu, Chaohua Li, Yuqi Chen, Yueli Zhang, Bo Lu
Summary: The study successfully developed ID@HMSNs-B-HA nanoparticles for targeted drug delivery, showing sustained drug release under acidic conditions with effective inhibition of murine mammary carcinoma (4T1) cells through combined chemotherapy and photodynamic therapy. The results indicated that ID@HMSNs-B-HA could be a promising nano-DDS for cancer treatment.
Article
Chemistry, Multidisciplinary
Yahua Liu, Fengye Mo, Jialing Hu, Qunying Jiang, Xiuyuan Wang, Zhiqiao Zou, Xian-Zheng Zhang, Dai-Wen Pang, Xiaoqing Liu
Summary: This study developed a tumor microenvironment-activated photothermal and photoacoustic agent for precise cancer diagnosis and treatment. Controllable plasmonic heating enables therapy and imaging in tumor tissues while avoiding damage to normal tissues.
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Ziling Zeng, Chi Zhang, Jingchao Li, Dong Cui, Yuyan Jiang, Kanyi Pu
Summary: This study introduces an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects for photodynamic immunometabolic therapy. By generating singlet oxygen (O-1(2)) upon NIR photoirradiation, SPNK induces immunogenic cell death of cancer and degrades immunosuppressive kynurenine (Kyn), ultimately promoting effector T cell proliferation and infiltration, enhancing systemic antitumor T cell immunity, and inhibiting both primary and distant tumors in living mice.
ADVANCED MATERIALS
(2021)
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Joaquim Torra, Taka Sawazaki, Patricia Bondia, Santi Nonell, Motomu Kanai, Youhei Sohma, Cristina Flors
Summary: The study discusses the use of iodinated boron dipyrromethene photocatalysts as theranostic compounds against pathogenic bacterial biofilms. These compounds selectively stain and weaken the mechanical barrier of the biofilm, allowing conventional antimicrobial agents to regain their activity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Zhi-Yuan Wu, Guan-wei Chen, Cheng-Chang Lee, Zui-Harng Lee, Wei Ting Yuan, Showe-Mei Lin, Hsiu-Mei Lin
Summary: Combination therapy of chemotherapy and photodynamic therapy can improve cancer treatment. In this study, nanoparticles capable of phototherapeutic effects were synthesized, and the combination therapy demonstrated superior anticancer efficacy compared to PDT or chemotherapy alone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yue-Mei Gao, Shih-Han Chiu, Prabhakar Busa, Chen-Lun Liu, Ranjith Kumar Kankala, Chia-Hung Lee
Summary: This study reports the fabrication of core-shell nanostructures for delivering methylene blue and copper-doxorubicin as model drugs for synergistic photodynamic therapy, chemotherapy, and chemodynamic therapy. The designed architectures demonstrate potent anti-cancer efficacy against skin melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jing Liu, Shasha He, Yingli Luo, Yue Zhang, Xiaojiao Du, Cheng Xu, Kanyi Pu, Jun Wang
Summary: This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, Yue Jiang, Qing Li, Qingqing Miao, Mingyuan Gao
Summary: Cancer-associated fibroblasts (CAFs) are major components of the tumor-associated matrix and play a crucial role in tumor progression and immunosuppression. A new molecular pro-theranostic probe (FMP) with activatable fluorescence, photoacoustic imaging, and photodynamic therapy has been developed to specifically target CAFs. This probe shows efficient activatable phototoxicity towards CAFs and tumor cells, leading to complete regression of primary tumors and abscopal effects on distant tumors in a mouse model. Furthermore, when combined with PD-L1 checkpoint blockade immunotherapy, it also induces enhanced systemic immune responses and long-lasting tumor suppression in living mice.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xuan He, Fangman Chen, Zhimin Chang, Kasim Waqar, Hanze Hu, Xiao Zheng, Yingshuai Wang, Wen-fei Dong, Chao Yang
Summary: This review comprehensively discusses the recent progress in the fabrication and application of silver mesoporous silica nanoparticles (Ag-MSNs) for combination therapies for cancer and infection. Different structures of Ag-MSNs are elaborated, and their applications in imaging, therapy, and antibacterial treatment are highlighted. The challenges and future directions are also summarized.
Review
Chemistry, Inorganic & Nuclear
Qingqing Xu, Yuanqi Yang, Junya Lu, Yuanzhe Lin, Shuaipeng Feng, Xinyi Luo, Donghua Di, Siling Wang, Qinfu Zhao
Summary: Nanodynamic therapies using nanosensitizers triggered by various activators or reactions in tumor microenvironment have emerged as attractive strategies for treating deep-seated tumors. Mesoporous silica nanoparticles (MSNs) and MSNs-based hybrid nanoparticles are promising candidates for nanodynamic therapies due to their large surface area, high pore volume, biosafety, and easy surface modification. This review summarizes the antitumor mechanisms and latest progress in the construction, modification, and application of MSNs-based nanodynamic therapies, including photodynamic therapy, chemodynamic therapy, sonodynamic therapy, thermodynamic therapy, radiodynamic therapy, and electrodynamic therapy. The challenges and prospects for clinical applications of MSNs-based ROS-activated cancer treatments are also discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jie Xu, Yi Lai, Fengyang Wang, Zhifeng Zou, Renjun Pei, Haijun Yu, Zhiai Xu
Summary: Photodynamic therapy (PDT) is an efficient and minimally invasive cancer treatment method. However, current photosensitizers often exhibit dark toxicity and low tumor specificity. To address this issue, researchers have developed a series of acid-activatable photosensitizers for highly sensitive PDT of triple-negative breast tumors. These novel photosensitizers can be activated in an acidic environment to generate reactive oxygen species (ROS) and emit fluorescence. They are also modified with a poly(ethylene glycol) (PEG) chain for prolonged blood circulation and magnetic resonance imaging (MRI) capability. The PEGylated photosensitizers can self-assemble into micellar nanoparticles for targeted tumor PDT. Furthermore, these nanoparticles can deliver the anticancer drug doxorubicin (DOX) and be used for fluorescence image-guided combination PDT and chemotherapy, effectively suppressing tumor growth in a mouse model. These acid-activatable photosensitizer-incorporated nanoparticles provide a versatile platform for precise PDT and combination breast cancer therapy.
CHINESE CHEMICAL LETTERS
(2023)
