Journal
NANOTECHNOLOGY
Volume 28, Issue 29, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa761b
Keywords
graphene oxide; poly(dopamine); photothermal therapy; drug delivery
Funding
- National Nature Science Foundation of China [81271689, 31271009]
- Program for New Century Excellent Talents in University, Scientific and Technological Innovation Platform of Fujian Province of China [2014H2006]
- Xiamen Municipal Science and Technology Project [3502Z20144026]
Ask authors/readers for more resources
For releasing both drug and heat to selected sites, a combination of chemotherapy and photothermal therapy in one system is a more effective way to destroy cancer cells than monotherapy. Graphene oxide (GO) with high drug-loading efficiency and near-infrared (NIR) absorbance has great potential in drug delivery and photothermal therapy, but it is difficult to load drugs with high solubility. Herein, we develop a versatile drug delivery nanoplatform based on GO for integrated chemotherapy and photothermal therapy by a facile method of simultaneous reduction and surface functionalization of GO with poly(dopamine) (PDA). Due to the excellent adhesion of PDA, both low and high solubility drugs can be encapsulated in the PDA-functionalized GO nanocomposite (rGO-PDA). The fabricated nanocomposite exhibits good biocompatibility, excellent photothermal performance, high drug loading capacity, an outstanding sustained release property, and efficient endocytosis. Moreover, NIR laser irradiation facilitates the release of loaded drugs from rGO-PDA. These features make the rGOPDA nanocomposite achieve excellent in vivo synergistic antitumor therapeutic efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available