Article
Engineering, Electrical & Electronic
Conrad Rizal
Summary: A novel sensor configuration based on magneto-optic-plasmonic surface plasmon resonance effect is proposed, compared to a conventional multilayer combination of metal and dielectrics. The optimized MOSPR sensor demonstrated significantly improved sensitivity and detection limits compared to the SPR sensor, almost 4 times better performance.
IEEE TRANSACTIONS ON MAGNETICS
(2021)
Article
Spectroscopy
Hyeong-Min Kim, Hyo-Jun Kim, Jae-Hyoung Park, Seung-Ki Lee
Summary: In this study, gold-palladium bimetallic nanodisks were successfully patterned on optical fibers, exhibiting high refractive index sensitivity and excellent hydrogen sensing performance. The fiber-optic plasmonic nanoprobe, based on nanosphere lithography and chemical growth, has the advantages of high throughput and low cost, making it suitable for remote sensing to detect dangerous environments in the clean energy era.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Analytical
Bianca-Georgiana Solomonea, Luiza-Izabela Jinga, Vlad-Andrei Antohe, Gabriel Socol, Iulia Antohe
Summary: A gold-coated reflection-type fiber optic-surface plasmon resonance (Au-coated FO-SPR) sensor is manufactured and functionalized with different materials for the sensitive detection of cadmium ions (Cd2+) in water. The BSA-functionalized FO-SPR sensor is found to be highly sensitive, with a limit of detection at the nanomolar level. The presence of Cd2+ on the sensor surface was confirmed and quantified using X-ray photoelectron spectroscopy (XPS). This study demonstrates that the BSA-functionalized FO-SPR sensor is a sensitive, rapid, cheap, and portable method for monitoring trace-level amounts of Cd in water.
Article
Nanoscience & Nanotechnology
Jose M. Viana, Manuel Romero, Gabriel Lozano, Hernan Miguez
Summary: This study demonstrates that metallic nanostructures prepared by colloidal lithography can enhance the brightness of nanophosphor emissions, providing an economical nanophotonic solution for developing bright emitting coatings.
ACS APPLIED NANO MATERIALS
(2022)
Article
Physics, Multidisciplinary
Wancong Li, Qiang Zhou, Pu Zhang, Xue-Wen Chen
Summary: This study proposes the concept of nanoscopic electron reservoir (NER) for direct electro plasmonic and electro-optic modulation. By exploiting the nonclassical effects of conduction electrons, highly electrically susceptible NERs are constructed and achieve pronounced direct electrical tuning of the plasmon mode. Moreover, the electro-plasmonic tuning can be efficiently translated into modulation of optical scattering.
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Martin Thomaschewski, Christian Wolff, Sergey Bozhevolnyi
Summary: The study demonstrates a plasmonic optical phased array (OPA) using plasmonic lithium niobate technology for efficient optical beam manipulation, achieving aliasing-free beam steering with an angular range of +/- 5 degrees, flat frequency response up to 18 GHz, and a potential bandwidth of 1.2 THz.
Review
Chemistry, Analytical
Yanting Liu, Xuming Zhang
Summary: This review summarizes the recent advances in plasmonic biosensors integrated with microfluidic chips for biomedical detection applications, showcasing enhanced performance through continuous advancements in plasmon resonance techniques. Microfluidic integration enables multiplexing opportunities for simultaneous detection of multiple analytes with high sensitivity, label-free, and real-time performance, benefiting a wide range of biomedical studies, chemical analyses, and point-of-care diagnostics.
Article
Chemistry, Multidisciplinary
Fons Dingenen, Rituraj Borah, Rajeshreddy Ninakanti, Sammy W. W. Verbruggen
Summary: In this work, we present a method to study the oxygen activation rate on plasmonic nanoparticles under visible light, and experimental results have been demonstrated. The oxygen activation rate on bimetallic gold-silver rainbow nanoparticles was determined and validated with experimental data using a kinetic model. Additionally, the experimental results of the broadband visible light driven oxygen activation capacity of this plasmonic rainbow system were shown, with a brief theoretical discussion on the possible mechanisms behind such plasmon-driven reactions.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Multidisciplinary
Yueqiang Hu, Ling Li, Rong Wang, Jian Song, Hongdong Wang, Huigao Duan, Jiaxin Ji, Yonggang Meng
Summary: A parallel plasmonic direct-writing nanolithography system has been established to achieve a minimum flying height of around 15 nm with high parallelism at a rotating speed of 8-18 m/s. Additionally, a multi-stage metasurface-based polarization insensitive plasmonic lens is proposed to couple more power and realize more confined spot compared to conventional plasmonic lenses. The prototyping system enables parallel lithography of nanostructures with the smallest linewidth around 26 nm.
Article
Chemistry, Multidisciplinary
Vaibhav Gupta, Swagato Sarkar, Olha Aftenieva, Takuya Tsuda, Labeesh Kumar, Daniel Schletz, Johannes Schultz, Anton Kiriy, Andreas Fery, Nicolas Vogel, Tobias A. F. Koenig
Summary: Imprint lithography, a combination of interference lithography and nanosphere imprint lithography, is an effective and direct method for patterning nanostructures on various substrates. This technique allows for the fabrication of nanodevices with high yield and quality, marking a milestone for large-scale implementation in optoelectronic devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Computer Science, Information Systems
Ajay Kumar Agrawal, Akanksha Ninawe, Anuj Dhawan
Summary: A surface plasmon resonance sensing and imaging platform based on plasmonic non-uniform nano-gratings with narrow groove is proposed, showing high sensitivity and ease of fabrication.
Article
Nanoscience & Nanotechnology
Xiaopeng Bai, Shiu Hei Lam, Jingtian Hu, Ka Kit Chui, Xiao-Ming Zhu, Lei Shao, Tsz Him Chow, Jianfang Wang
Summary: This study reports the gram-scale production of cost-effective TiN nanoparticles with strong plasmonic properties and their application in solar seawater desalination. The TiN nanoparticles achieved high evaporation rates and excellent removal percentages of organic compounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Pau Molet, Nicolas Passarelli, Luis A. Perez, Leonardo Scarabelli, Agustin Mihi
Summary: Ordered arrays of metal nanoparticles can generate surface lattice resonances with higher quality factors, showing great potential for engineering light-matter interactions. The internal architecture of gold-nanoparticle meta-molecules influences the optical response of plasmonic supercrystals.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
A. A. Salim, H. Bakhtiar, M. S. Shamsudin, M. S. Aziz, A. R. Johari, S. K. Ghoshal
Summary: Stable rose bengal dye-decorated gold nanoparticles prepared by pulsed laser ablation in liquid method showed enhanced fluorescence and localized surface plasmon resonance absorption, resulting in a fiber-optic humidity sensor with higher sensitivity and linearity compared to pure gold nanoparticles. The improvement can be attributed to the adherence mechanism between the functional groups on the surface of rose bengal dye-decorated gold nanoparticles and polyvinyl alcohol molecules, enabling strong binding.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Multidisciplinary
Dandan Han, Tianchun Ye, Yayi Wei
Summary: In this paper, a cost-effective and high-fidelity nanolithography technique is proposed, which combines the high-resolution capability of maskless plasmonic lithography with the spatial morphology controllability of grayscale lithography. The technique allows for the generation of customized patterns from microscale to nanoscale, and has wide applications in various fields including integrated circuits, MEMS/NEMS, optical devices, and nanophotonics.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Jia-Huan Qu, Karen Leirs, Wim Maes, Maya Imbrechts, Nico Callewaert, Katrien Lagrou, Nick Geukens, Jeroen Lammertyn, Dragana Spasic
Summary: The ongoing COVID-19 pandemic has highlighted the need for rapid and accurate diagnostic tools. In addition to this, serological tests have become important for understanding patients' immune status and past viral infections. This study presents a novel approach for measuring antibody levels and profiling their binding kinetics, which is not possible with traditional serological tests. The method was successfully used in COVID-19 patient serum and undiluted whole blood, without the need for sample preparation, and provided results in a significantly shorter time compared to other tests. The results also showed that there is no direct correlation between antibody levels and their binding kinetics in different COVID-19 patients, suggesting that antibodybinding kinetics may play a role in the severity of the disease.
Article
Biophysics
Saba Safdar, Seppe Driesen, Karen Leirs, Delphine De Sutter, Sven Eyckerman, Jeroen Lammertyn, Dragana Spasic
Summary: In recent years, CRISPR-Cas-based technologies have gained increasing attention in the biosensing field. Researchers have successfully integrated flexible signal generation and amplification properties into the CRISPR-dCas9 complex by incorporating a DNA sequence, allowing for the detection of nucleic acid targets.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Jia-Huan Qu, Henry Ordutowski, Charlotte Van Tricht, Ruben Verbruggen, Alicia Barcenas Gallardo, Mattijs Bulcaen, Marta Ciwinska, Carolina Gutierrez Cisneros, Christophe Devriese, Sona Guluzade, Xander Janssens, Sophie Kornblum, Yuansheng Lu, Nika Marolt, Chezhiyan Nanjappan, Eline Rutten, Eline Vanhauwaert, Nick Geukens, Debby Thomas, Francesco Dal Dosso, Saba Safdar, Dragana Spasic, Jeroen Lammertyn
Summary: This study presents a method for therapeutic drug monitoring (TDM) of adalimumab (ADM) in the doctor's office using an ADM-sensor. The sensor combines fiber optic surface plasmon resonance (FO-SPR) technology with self-powered microfluidics to create a point of care (POC) setting. The ADM-sensor demonstrates comparable performance to existing POC biosensors for ADM quantification in patient plasma samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Polymer Science
Ion Sandu, Claudiu Teodor Fleaca, Florian Dumitrache, Bogdan Alexandru Sava, Iuliana Urzica, Iulia Antohe, Simona Brajnicov, Marius Dumitru
Summary: Silica and polystyrene spheres with a small size ratio (r = 0.005) were assembled into a binary colloidal crystal through sequential hanging drop self-assembly. The crystal could undergo calcination to transform into a silica-ordered concavity array, which exhibited light Bragg diffraction and shape dependent optical phenomena. Moreover, it could be further transformed into inverse-opal structures. Hierarchical 2D and 3D super-structures with ordered concavities as structural units were successfully fabricated in this study.
Article
Biophysics
Henry Ordutowski, Francesco Dal Dosso, Wout De Wispelaere, Charlotte Van Tricht, Severine Vermeire, Nick Geukens, Ann Gils, Dragana Spasic, Jeroen Lammertyn
Summary: A novel self-powered microfluidic chip was developed for point-of-care therapeutic drug monitoring of adalimumab, enabling detection within 30 minutes directly from whole blood.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Ana-Maria Panaitescu, Iulia Antohe, Claudiu Locovei, Sorina Iftimie, Stefan Antohe, Luc Piraux, Mirela Petruta Suchea, Vlad-Andrei Antohe
Summary: This work presents a method for preparing nanostructured electrodes based on vertically-aligned copper nanowires covered with cadmium telluride thin films. These electrodes have great potential for use in substrate-type photovoltaic cells. The multi-step preparation protocol involves electrochemical synthesis of copper nanowires within an anodic aluminum oxide template, and embedding them in a compact cadmium telluride thin film. The study compares three deposition methods for obtaining CdTe layers that can consistently penetrate the prepared copper nanowire array. The results show that under optimized conditions, the electrochemical deposition method could allow the cost-effective fabrication of efficient solar cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Bianca-Georgiana Solomonea, Luiza-Izabela Jinga, Vlad-Andrei Antohe, Gabriel Socol, Iulia Antohe
Summary: A gold-coated reflection-type fiber optic-surface plasmon resonance (Au-coated FO-SPR) sensor is manufactured and functionalized with different materials for the sensitive detection of cadmium ions (Cd2+) in water. The BSA-functionalized FO-SPR sensor is found to be highly sensitive, with a limit of detection at the nanomolar level. The presence of Cd2+ on the sensor surface was confirmed and quantified using X-ray photoelectron spectroscopy (XPS). This study demonstrates that the BSA-functionalized FO-SPR sensor is a sensitive, rapid, cheap, and portable method for monitoring trace-level amounts of Cd in water.
Article
Nanoscience & Nanotechnology
Ana-Maria Panaitescu, Iulia Antohe, Ana-Maria Raduta, Sorina Iftimie, Stefan Antohe, Cristian Nicolae Mihailescu, Vlad-Andrei Antohe
Summary: In this study, zinc telluride thin films were deposited on optical glass using radio-frequency magnetron sputtering. The films were characterized optically and electrically, showing excellent properties for high-performance small-wavelength photodetectors.
Article
Chemistry, Multidisciplinary
Luiza Izabela Toderascu, Livia Elena Sima, Stefana Orobeti, Paula Ecaterina Florian, Madalina Icriverzi, Valentin-Adrian Maraloiu, Cezar Comanescu, Nicusor Iacob, Victor Kuncser, Iulia Antohe, Gianina Popescu-Pelin, George Stanciu, Petre Ionita, Cristian N. N. Mihailescu, Gabriel Socol
Summary: In this study, L-Cysteine-coated magnetic iron oxide nanoparticles loaded with doxorubicin were synthesized and extensively characterized. The binding of doxorubicin to L-Cysteine was confirmed, and the internalization of the nanoparticles delivering doxorubicin was observed in melanoma cells. The nanoparticles also modulated cell signaling pathway activity, induced cell cycle arrest and apoptosis, and exhibited pH-dependent drug release. These results demonstrate the potential of the nanoparticles as efficient drug delivery vehicles in melanoma therapy.
Article
Chemistry, Physical
Jolien Breukers, Karen Ven, Caroline Struyfs, Louanne Ampofo, Iene Rutten, Maya Imbrechts, Francesca Pollet, Julie Van Lent, Winnie Kerstens, Sam Noppen, Dominique Schols, Paul De Munter, Hendrik Jan Thibaut, Karen Vanhoorelbeke, Dragana Spasic, Paul Declerck, Bruno P. A. Cammue, Nick Geukens, Karin Thevissen, Jeroen Lammertyn
Summary: FLUIDOT is a versatile microfluidic platform that incorporates customizable microwells, optical tweezers, and an interchangeable cell-retrieval system. It is straightforward to fabricate and operate, making it widely accessible. FLUIDOT's performance and flexibility have been validated and demonstrated in two applications, allowing for the study and screening of single cells.
Article
Biochemistry & Molecular Biology
Yagmur Yildizhan, Kaat Driessens, Hong Shen Kevin Tsao, Robin Boiy, Debby Thomas, Nick Geukens, An Hendrix, Jeroen Lammertyn, Dragana Spasic
Summary: EVs have great potential as biomarkers for cancer diagnostics. There is a need for sensitive and standardized EV detection methods. We have developed a bioassay using a FO-SPR biosensor, which shows remarkable sensitivity and specificity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Henry Ordutowski, Cesar Parra-Cabrera, Clement Achille, Ruben Dochy, Francesco Dal Dosso, Jeroen Lammertyn, Rob Ameloot, Dragana Spasic
Summary: Although efficient diagnostic testing often relies on centralized laboratories, rapid diagnostics at the point-of-care (POC) are increasingly investigated to provide an affordable and easy-to-use alternative that requires minimal external equipment. 3D printing is a promising technology to enable the single-step fabrication of POC diagnostic devices. In this study, the researchers aimed to improve the time-to-result and detection limit of the 3D-printed microfluidic device used for enzyme-linked immunosorbent assay (ELISA) by designing a second-generation device and optimizing the IgE ELISA.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Aida Montserrat Pages, Maarten Hertog, Bart Nicolai, Dragana Spasic, Jeroen Lammertyn
Summary: A mathematical model describing and predicting the reaction of a 10-23 RNA-cleaving DNAzyme is presented for the first time, expanding the range of conditions in which the model can be used.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Matthias Corion, Simao Santos, Bart De Ketelaere, Dragana Spasic, Maarten Hertog, Jeroen Lammertyn
Summary: Numerous researchers and institutions are developing sexing technologies to improve animal welfare. This review provides a comprehensive overview of the technological approaches reported in papers and patents. A total of 49 papers and 115 patent families were analyzed, and 11 technology categories were identified. The differences between technologies in papers and patents were observed, with more diverse approaches found in patents. It was also noted that none of the technologies fully comply with industry requirements, but 5 companies have entered the market. Close monitoring of market performance and further research are needed.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caroline Struyfs, Jolien Breukers, Dragana Spasic, Jeroen Lammertyn, Bruno P. A. Cammue, Karin Thevissen
Summary: Single cell analyses have become popular due to cell-to-cell variability, while flow cytometry remains the gold standard, limiting the investigation of interdependency of cellular events. In this study, using a microfluidic platform, the kinetic responses of single yeast cells to antifungal treatment were investigated, revealing the close interdependency between reactive oxygen species (ROS) induction and membrane permeabilization (MP).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)