Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses

Common single nucleotide variants underlying drug addiction: more than a decade of research

(2015) Kora-Mareen Bühler et al.   ADDICTION BIOLOGY

Genome-Wide Association Studies in Africans and African Americans: Expanding the Framework of the Genomics of Human Traits and Disease

(2015) Emmanuel Peprah et al.   Public Health Genomics

Topiramate Treatment for Heavy Drinkers: Moderation by aGRIK1Polymorphism

(2014) Henry R. Kranzler et al.   AMERICAN JOURNAL OF PSYCHIATRY

Multi-view singular value decomposition for disease subtyping and genetic associations

(2014) Jiangwen Sun et al.   BMC GENETICS

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

XRCC5 as a Risk Gene for Alcohol Dependence: Evidence from a Genome-Wide Gene-Set-Based Analysis and Follow-up Studies in Drosophila and Humans

(2014) Dilafruz Juraeva et al.   NEUROPSYCHOPHARMACOLOGY

The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies

(2014) B. Verhulst et al.   PSYCHOLOGICAL MEDICINE

Genetic risk prediction and neurobiological understanding of alcoholism

(2014) D F Levey et al.   Translational Psychiatry

Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence

(2013) Jia Yan et al.   ADDICTION BIOLOGY

Family-Based Association Analysis of Alcohol Dependence Criteria and Severity

(2013) Leah Wetherill et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence

(2013) Shizhong Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis

(2013) Jinbo Bi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

ALDH2is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sample

(2013) Ellen E. Quillen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Three Mutually Informative Ways to Understand the Genetic Relationships Among Behavioral Disinhibition, Alcohol Use, Drug Use, Nicotine Use/Dependence, and Their Co-occurrence: Twin Biometry, GCTA, and Genome-Wide Scoring

(2013) Scott I. Vrieze et al.   BEHAVIOR GENETICS

A Genome-Wide Association Study of Behavioral Disinhibition

(2013) Matt McGue et al.   BEHAVIOR GENETICS

Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways

(2013) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

Common biological networks underlie genetic risk for alcoholism in African- and European-American populations

(2013) M. Z. Kos et al.   GENES BRAIN AND BEHAVIOR

Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants

(2013) Can Yang et al.   HUMAN GENETICS

A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks

(2013) Manav Kapoor et al.   HUMAN GENETICS

Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication

(2013) Byung Lae Park et al.   HUMAN GENETICS

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci

(2013) J Gelernter et al.   MOLECULAR PSYCHIATRY

Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene

(2013) J Gelernter et al.   MOLECULAR PSYCHIATRY

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Genetic Influences on the Development of Alcoholism

(2013) Mary-Anne Enoch   Current Psychiatry Reports

Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors

(2012) Jiangwen Sun et al.   ADDICTIVE BEHAVIORS

Convergence of Genome-Wide Association and Candidate Gene Studies for Alcoholism

(2012) Emily Olfson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The genetics of alcohol dependence

(2012) Marcella Rietschel et al.   Annals of the New York Academy of Sciences

Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence

(2012) Joanna M. Biernacka et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

(2012) J-C Wang et al.   MOLECULAR PSYCHIATRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative Associations, Including Cadherin 13 (CDH13)

(2012) Amy B. Hart et al.   PLoS One

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

(2012) Purvesh Khatri et al.   PLoS Computational Biology

Comparison of Family History and SNPs for Predicting Risk of Complex Disease

(2012) Chuong B. Do et al.   PLoS Genetics

The genetics of addiction—a translational perspective

(2012) A Agrawal et al.   Translational Psychiatry

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster

(2011) Josef Frank et al.   ADDICTION BIOLOGY

Genomewide Association Analysis of Symptoms of Alcohol Dependence in the Molecular Genetics of Schizophrenia (MGS2) Control Sample

(2011) Kenneth S. Kendler et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men

(2011) Inkyung Baik et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and Implications

(2011) Andrew C. Heath et al.   BIOLOGICAL PSYCHIATRY

Confirmation of ALDH2 as a Major Locus of Drinking Behavior and of Its Variants Regulating Multiple Metabolic Phenotypes in a Japanese Population

(2011) Fumihiko Takeuchi et al.   CIRCULATION JOURNAL

Gene set analysis of genome-wide association studies: Methodological issues and perspectives

(2011) Lily Wang et al.   GENOMICS

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

(2011) L J Bierut et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q

(2011) Lingjun Zuo et al.   NEUROPSYCHOPHARMACOLOGY

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

(2011) G. Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11

(2010) Howard J. Edenberg et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Evidence for Polygenic Susceptibility to Multiple Sclerosis—The Shape of Things to Come

(2010)   AMERICAN JOURNAL OF HUMAN GENETICS

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

dmGWAS: dense module searching for genome-wide association studies in protein–protein interaction networks

(2010) Peilin Jia et al.   BIOINFORMATICS

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

A genome-wide association study of alcohol dependence

(2010) L. J. Bierut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Markers in the 3′ Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol Dependence

(2009) Henry R. Kranzler et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder

(2009) Peter Holmans et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Study of Alcohol Dependence

(2009) Jens Treutlein et al.   ARCHIVES OF GENERAL PSYCHIATRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Haplotypic Variants inDRD2,ANKK1,TTC12, andNCAM1are Associated With Comorbid Alcohol and Drug Dependence

(2008) Bao-Zhu Yang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH