Article
Chemistry, Multidisciplinary
Man-Di Wang, Gan-Tian Lv, Hong-Wei An, Ni-Yuan Zhang, Hao Wang
Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ni-Yuan Zhang, Da-Yong Hou, Xing-Jie Hu, Jian-Xiao Liang, Man-Di Wang, Zhang-Zhi Song, Li Yi, Zhi-Jia Wang, Hong-Wei An, Wanhai Xu, Hao Wang
Summary: Reported here is an intracellular fabricated Nano-PROTACs modality with a center-spoke degradation network, which achieves efficient dose-dependent protein degradation in tumor. Nano-PROTACs are self-assembled by intermolecular hydrogen bond interactions triggered by higher GSH concentrations inside tumor cells, forming fibrous structures that can form effective polynary complexes and E3 ligases degradation network. Nano-PROTACs demonstrate dose-dependent protein degradation of variable proteins of interest (POI) in vitro, with a degradation rate of 95% and long-lasting potency up to 72 h. In vivo, Nano-PROTACs achieve dose-dependent protein degradation up to 79% and tumor growth inhibition in xenograft mouse models.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Zhengqing Guo, Hui He, Yi Zhang, Jiaming Rao, Tao Yang, Ting Li, Lu Wang, Mengke Shi, Mengya Wang, Shihong Qiu, Xue Song, Hengte Ke, Huabing Chen
Summary: This study demonstrates the use of self-assembled micellar nanoarchitecture for potent phototherapy against triple-negative breast cancer, showing efficient suppression against primary, metastatic, and recurrent TNBC through tunable photoconversion and cytoplasmic translocation.
ADVANCED MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Shanshan Xu, Chunyu Liu, Shuya Zang, Jiaxin Li, Yashi Wang, Kebai Ren, Man Li, Zhirong Zhang, Qin He
Summary: The synthesized CT NPs can effectively inhibit cancer metastasis and provide excellent therapeutic effects on solid tumors and metastases.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qiuhong Zhang, Meijuan He, Xiaodong Zhang, Hongwei Yu, Jiawei Liu, Yi Guo, Junmin Zhang, Xiangzhong Ren, Han Wang, Yanli Zhao
Summary: This study reports the development of a tumor microenvironment-activable ROS-generating system using a protein-based nanomedicine that undergoes multistage self-assembly. The system offers effective self-protection for normal tissues and achieves tumor-specific therapy, providing a powerful strategy for nanomedicine design and precise cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Amir Barzegar Behrooz, Zahra Talaie, Amir Syahir
Summary: Aggressive glioblastoma (GBM) is a primary brain tumor with no known treatment. However, drug delivery based on nanotechnology holds the potential to address the challenges of treating GBM. Combination therapies have shown better efficacy in GBM treatment, and nanotechnology can enhance the effectiveness of combination treatments.
Article
Chemistry, Applied
Jing Han, Huan Deng, Yang Li, Lichun Qiao, Hongrui Jia, Lan Zhang, Linghang Wang, Chengjuan Qu
Summary: A nano-elemental selenium particle (CSA-SeNP) is developed for cartilage repair, which can promote chondrocyte proliferation, increase cartilage thickness, and improve the ultrastructure of chondrocytes and organelles. It enhances the expression of chondroitin sulfate 4-O sulfotransferase to repair cartilage lesions and is less toxic than Na2SeO3, showing outstanding repair effects in rats.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Peng Liu, Xinyi Shi, Ying Peng, Jianming Hu, Jinsong Ding, Wenhu Zhou
Summary: This study develops a metal-phenolic networks (MPNs) nanoplatform for synergistic ferroptosis-immunotherapy cyclical treatment of tumors. By combining photothermal therapy and PD-L1 pathway regulation, a self-amplified tumor treatment strategy is successfully achieved.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Xiayi Liang, Yan Zhang, Jing Zhou, Zhaoting Bu, Junjie Liu, Kun Zhang
Summary: This article reviews the recent progress and rationales of intratumoral stimuli-responsive in situ assembly of supramolecular self-assemblies based on artificial small molecule nanomaterials in tumors. It explores the tumor-related stimulatory response components and summarizes the intermolecular driving forces or interactions after TME-triggered precursor cleavage. The article sheds light on the design concepts and application innovation in the field of tumor diagnosis and treatment, while also discussing the challenges and potential solutions for intratumoral stimuli-responsive supramolecular self-assembly synthesis.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Feng Li, Xiaolei Sun, Jing Yang, Jin Ren, Mengxue Huang, Shengqi Wang, Dayong Yang
Summary: A DNA-based nanomachine is developed for efficient delivery of mRNA, which can capture, store, and deliver mRNA in cells. The nanomachine is composed of a polythymidine acid-functionalized poly(N-isopropylacrylamide) core, which can transform into an extension state to expose the poly-T for hybridization with mRNA, and re-assemble for mRNA encapsulation. The nanomachine achieves long-term storage of mRNA at 37°C and facilitates mRNA delivery through the endocytosis and release in the cytoplasm. This work provides a new design principle for mRNA delivery nanosystems.
Review
Nanoscience & Nanotechnology
Xiang He, Shentao Zhang, Yuhang Tian, Wen Cheng, Hui Jing
Summary: With the booming development of nanomedicine, mild photothermal therapy (mPTT) has shown great potential in tumor therapy. Compared with traditional PTT, mPTT has fewer side effects and better biological effects. However, the relatively low temperature of mPTT cannot completely eradicate tumors, so efforts have been made to optimize its application in tumor therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Nayereh Azimijou, Reza Karimi-Soflou, Akbar Karkhaneh
Summary: This study presents a practical method to overcome the challenges of chemotherapy in aggressive breast tumors using tamoxifen-loaded redox-sensitive nanoparticles. These nanoparticles exhibit enhanced apoptosis-inducing effects on breast cancer cells and can accurately accumulate in the tumor region in vivo, showing promising potential as an efficient chemotherapeutic drug carrier for combating breast cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Lili Zhou, Manshu Zou, Yilin Xu, Peng Lin, Chang Lei, Xinhua Xia
Summary: Tumor immunotherapy is a powerful strategy for treating cancer by stimulating the immune system. However, the heterogeneity of tumors and immunosuppressive microenvironment make it difficult for immunotherapy to be effective. With the advancements in materials science and nanotechnology, innovative biomaterials and drug delivery systems can enhance the effectiveness of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Rui R. Costa, Rui L. Reis, Iva Pashkuleva
Summary: The negative charge of glycosaminoglycans (GAG) allows them to form complexes with positively charged biomolecules and ions, regulating homeostatic functions. Copying these interactions enables the assembly of biofunctional devices with unprecedented biocompliance. However, there are challenges in complexing GAG into intricate three-dimensional networks.
INTERNATIONAL MATERIALS REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Iuliia Pilipenko, Viktor Korzhikov-Vlakh, Annika Valtari, Yurii Anufrikov, Stanislav Kalinin, Marika Ruponen, Mikhail Krasavin, Arto Urtti, Tatiana Tennikova
Summary: This study investigated two types of nanogels for improving ocular drug delivery, showing that cross-linked nanogels with disulfide linkages and thiol groups have enhanced mucoadhesive properties. In vivo intraocular pressure studies also demonstrated that polymers in solution can affect the ocular absorption of certain drugs, indicating the potential of these copolymers for ocular drug delivery applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
