Journal
NANOSCALE
Volume 9, Issue 33, Pages 12150-12162Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr03964f
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Funding
- Agence Nationale pour la Recherche [ANR-14-CE08-0014-01]
- French program Investissement d'Avenir by Agence Nationale pour la Recherche [ANR11-INBS-0006]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
- Chevreul Institute [FR 2638]
- Ministere de l'Enseignement Superieur et de la Recherche, Region Hauts-de-France
- FEDER
- ICMG [FR2607]
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Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light-and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues. Our findings indicate that coumarin-containing HA-based nanogels may be promising delivery systems for anticancer chemotherapy.
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