Article
Chemistry, Multidisciplinary
Ramya Kannan, Ayan Datta, Palani Prabakaran, Edamana Prasad, Vignesh Muthuvijayan
Summary: A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles with tunable morphology by varying the hydrophilic chain length. These 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, exhibited sustained release of the drug, and effectively penetrated cancer cells through caveolae-dependent endocytosis.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Steven T. G. Street, Yunxiang He, Robert L. Harniman, Juan Diego Garcia-Hernandez, Ian Manners
Summary: We developed a modular and functionalizable platform for producing biocompatible core-shell block copolymer nanofibers of controlled length. These nanofibers had a crystalline core and a corona that could be easily modified to incorporate imaging agents and targeting groups. The results provide a foundation for the future development of precision polymer nanofibers.
Article
Polymer Science
Seonghyeon Ahn, Hyeongkeon Yoon, Chao Duan, Weihua Li, Jin Kon Kim
Summary: This study prepared core-satellite micelles using a linear tetrablock copolymer and observed different shapes of micelles. A core-satellite structure was observed when the volume fraction was large, while a separate satellite structure was observed when the volume fraction was small.
Article
Chemistry, Analytical
Jihun Woo, Jiwoong Kim, Joohoon Kim
Summary: In this study, we report enhanced electrochemiluminescence (ECL) using a closed bipolar electrode (BPE) system modified with catalytic Pt nanoparticles. The system demonstrated sensitive and stable ECL emission under a low driving voltage and exhibited improved sensitivity and stability for bipolar ECL imaging analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Guillermo Leobardo Rodriguez-Acosta, Carlos Hernandez-Montalban, Maria Fernanda Sabrina Vega-Razo, Irving Osiel Castillo-Rodriguez, Marcos Martinez-Garcia
Summary: In recent years, there has been increasing interest in the application of polymeric materials that can self-assemble into micelles, particularly in biomedicine. The morphology of micelles plays a crucial role in drug transport and delivery, as they can encapsulate hydrophobic molecules, improve drug solubility, and incorporate bioactive molecules. Amphiphilic dendrimer micelles have shown promising results in nanotherapies.
CURRENT DRUG TARGETS
(2022)
Article
Chemistry, Multidisciplinary
Taejun Eom, Viktor Barat, Anzar Khan, Mihaiela C. Stuparu
Summary: A combination of supramolecular and covalent chemistry is used to create fullerene-containing polymer nanoparticles with a core-shell structure, overcoming the issue of poor water solubility.
Article
Polymer Science
J. Diego Garcia-Hernandez, Steven T. G. Street, Yuetong Kang, Yifan Zhang, Ian Manners
Summary: The design of an ABC triblock copolymer allows the creation of nanofibers with a crystalline core and a solubilizing PBMA corona, addressing the encapsulation issue. During solvent switch, successful encapsulation of a hydrophobic dye in the outer PBMA core was achieved, with efficient release facilitated by reverse solvent switch.
Article
Chemistry, Physical
Jia Tian, Song-Hai Xie, Ufuk Borucu, Shixing Lei, Yifan Zhang, Ian Manners
Summary: High-resolution cryo-electron microscopy is used to obtain detailed structures of solvated corona chains and sub-nanometre crystalline core lattice of polymer-based nanofibres in solution. This research provides important insights into the formation of uniform core-shell micellar nanoparticles using crystallizable block copolymers and pi-stacking molecular amphiphiles. The findings show the highly ordered crystal lattice of poly(ferrocenyldimethylsilane)-b-4-vinylpyridine nanofibres, providing a basis for further molecular modelling analysis.
Editorial Material
Nanoscience & Nanotechnology
Jiang Li, Chunhai Fan
Summary: A newly discovered DNA nanodevice can selectively modulate the lysosomal protease activity in tumour-associated macrophages, enhancing their antigen presentation ability and attenuating tumor growth in vivo.
NATURE NANOTECHNOLOGY
(2021)
Article
Clinical Neurology
Christina L. Nemeth, Ozgul Gok, Sophia N. Tomlinson, Anjali Sharma, Ann B. Moser, Sujatha Kannan, Rangaramanujam M. Kannan, Ali Fatemi
Summary: X-linked adrenoleukodystrophy (ALD) is a genetic disorder caused by mutations in the ABCD1 gene. Treatments for the disease are limited, but using a D-4PBA conjugate shows promise in improving efficacy.
Article
Clinical Neurology
Christina L. Nemeth, Ozgul Gok, Sophia N. Tomlinson, Anjali Sharma, Ann B. Moser, Sujatha Kannan, Rangaramanujam M. Kannan, Ali Fatemi
Summary: This study demonstrates the improved efficacy of D-4PBA, a conjugate of 4-Phenylbutyrate (4PBA) and hydroxyl polyamidoamine (PAMAM) dendrimers, compared to previous studies of free 4PBA alone. The D-4PBA conjugate shows promise in the treatment of X-linked adrenoleukodystrophy (ALD) by upregulating Abcd2 and its downstream pathways, leading to neurobehavioral improvement and reduction of very long chain fatty acids (VLCFA).
Article
Chemistry, Multidisciplinary
Yue-Jiao Zhang, Petar M. Radjenovic, Xiao-Shun Zhou, Hua Zhang, Jian-Lin Yao, Jian-Feng Li
Summary: Plasmonic core-shell nanostructures have highly tunable optical properties, and when excited by an incident laser, generate strong and highly localized electromagnetic fields that significantly enhance excitation and/or radiation processes to amplify signals and improve spectroscopic sensitivity.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hoa Duc Trinh, Sangwoon Yoon
Summary: In this study, a potential solution for developing highly sensitive and stable surface-enhanced Raman scattering (SERS) probe systems was presented. The silica-coated core-satellite (CS@SiO2) plasmonic nanoparticle assembly structures demonstrated multiple hot spots and narrow nanogaps, resulting in significantly enhanced Raman scattering signals with various applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Environmental
Ellis Hammond-Pereira, Xianghui Zhang, Di Wu, Steven R. Saunders
Summary: This study demonstrates the ability to individually tune the pore length and diameter of silica-encapsulated gold core-shell nanoparticles through a seeded encapsulation method. The results show that increasing shell thickness enhances the formation of the desired aldehyde product, while increasing pore diameter leads to unselective formation of both aldehyde and ester products.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Balamurugan Devadas, Arun Prakash Periasamy, Karel Bouzek
Summary: This review focuses on the development of poly(amidoamine) (PAMAM) dendrimer encapsulated metal nanoparticles (NPs), known as Dend-NPs, as catalysts in electro-chemical energy conversion and storage. Different strategies to improve energy production efficiency and performance retention in electrochemical systems are emphasized, with a summary of the catalytic actions of Dend-NPs in various electrochemical reactions. Discussions include the synthesis of metal NPs within dendrimers, difficulties, solutions, and the classification of PAMAM dendrimers for potential use in energy technologies.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fijs W. B. van Leeuwen, Margret Schottelius, Felix M. Mottaghy, Fabien Hyafil, Mark Lubberink, Gabriela Kramer-Marek, Wim J. G. Oyen
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Imke Boekestijn, Meta Roestenberg, Gijs H. KleinJan, Jos A. van der Hage, Henk G. van der Poel, Daphne D. D. Rietbergen, Matthias N. van Oosterom, Fijs W. B. van Leeuwen
Summary: This study investigates the impact of signal-to-background ratios (SBR) on surgical performance using kinematics analysis. The results show that below SBR 1.5, task completion time, time spent in fluorescence-imaging mode, and total pathlength increase significantly, and handling errors become more frequent. The values of Dx and DM indicate that proficiency can only be achieved at SBR> 1.55.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Rebecca Kaup, Aldrik H. Velders
Summary: This study investigates the dynamics of polyamidoamine (PAMAM) dendrimer based micelles and shows that they can be manipulated by changing dendrimer generation, pH, and stoichiometry. The results reveal the exchange of dendrimers between micellar cores and demonstrate the importance of dendrimer generation, charge density, and stoichiometry in controlling the dynamics of complex coacervate core micelles.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jean-Pierre Pouget, Mark Konijnenberg, Uta Eberlein, Gerhard Glatting, Pablo Minguez Gabina, Ken Herrmann, Soren Holm, Lidia Strigari, Fijs W. B. van Leeuwen, Michael Lassmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthias N. van Oosterom, Leon J. Slof, Fijs W. B. van Leeuwen, Henk G. van der Poel, Tessa Buckle
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Physical
Laura M. I. Schijven, Vittorio Saggiomo, Aldrik H. Velders, Johannes H. Bitter, Constantinos V. Nikiforidis
Summary: Researchers have discovered that solid or hollow microparticles can be formed using proteins with different aggregate sizes. By mixing proteins with CaCl2 and Na2CO3 solutions, and then adding Au3+ ions, solid and hollow protein microparticles with embedded gold nanoparticles can be fabricated. This method has a broader range of applications, including biomaterial preparation and multimodal imaging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Anne-Claire Berrens, Maarten L. Donswijk, Esther M. K. Wit, Fijs W. B. van Leeuwen, Pim J. van Leeuwen, Henk G. van der Poel
JOURNAL OF UROLOGY
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Article
Multidisciplinary Sciences
M. Victoria Gomez, Sander Baas, Aldrik H. Velders
Summary: Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for molecular characterization and quantification, but is limited by poor sensitivity and expensive hardware. In this study, a microfluidic NMR-chip with a single planar-spiral microcoil and photochemically induced hyperpolarization is used for multidimensional and heteronuclear NMR experiments on picomole quantities of material. This chip significantly improves sensitivity and reduces cost and hardware complexity compared to traditional instruments.
NATURE COMMUNICATIONS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthias N. van Oosterom, Samaneh Azargoshasb, Leon J. Slof, Fijs W. B. van Leeuwen
Summary: With the increasing use of robotic platforms in laparoscopic surgery, radioguidance has the potential to play a crucial role in improving surgical precision. Although there are challenges and limitations, recent developments have shown progress in integrating radioguidance with robotic laparoscopic surgery.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Surgery
Matthias N. van Oosterom, Sven van Leeuwen, Elio Mazzone, Paolo Dell'Oglio, Tessa Buckle, Florian van Beurden, Michael Boonekamp, Huybert van de Stadt, Kevin Bauwens, Herve Simon, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W. B. van Leeuwen
Summary: This study engineered a 'click-on' fluorescence detector that transforms standard robotic instruments into molecular sensing devices, enabling the detection of near-infrared fluorescence in a white-light setting. The detector showed promising performance in detecting blood vessels, assessing vascularization, and localizing lymph nodes during robotic surgery in pigs and human specimen evaluation.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
