Article
Oncology
Hector Teran-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Banos, Felix Campos-Juanatey, Sonsoles Yanez-Diaz, Almudena Garcia-Castano, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez
Summary: The study proposes a novel immunotherapy using gold nanoparticles bound to a bacterial toxin peptide as nanovaccines, showing promising results in pre-clinical experiments on bladder cancer. These nanovaccines activate the immune system, block tumor immunosuppression, and reduce tumor size. The potential of this immunotherapy can be extended to other solid tumors with lymphocyte infiltration.
Article
Biochemistry & Molecular Biology
Zhonghua Ji, Bingying Lin, Enshuang Guan, Mingsen Zhou, Hui Wang, Ying Hu
Summary: Melanoma, the deadliest type of skin cancer, has seen significant improvement in patient survival through anti-tumor immunotherapy. However, physiological barriers hinder drug bioavailability. Cell membranes, such as B16F10 cell membranes (BFMs), have emerged as promising drug delivery vehicles. In this study, BFMs acted as both antigens and vesicles for vaccines, overcoming immune tolerance by being taken up by dendritic cells (DCs) and combined with adjuvants. WT-modified BFMs (WT-BFMs) coated with F127-PTX showed enhanced cellular uptake and elicited robust immune responses.
Article
Chemistry, Multidisciplinary
Yifeng Xia, Jingjing Wei, Songsong Zhao, Beibei Guo, Fenghua Meng, Bert Klumperman, Zhiyuan Zhong
Summary: The study introduced a robust systemic delivery vehicle, cRGD-CPs, for oncolytic peptide LTX-315, demonstrating significant anti-tumor effects in a mouse model of malignant B16F10 melanoma. The combination with CpG adjuvant and anti-PD-1 antibody enhanced the immunotherapeutic efficacy, leading to tumor regression and long-term immune memory protection in some cases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Lina S. Farhoumand, Miltiadis Fiorentzis, Miriam M. Kraemer, Ali Sak, Martin Stuschke, Tienush Rassaf, Ulrike Hendgen-Cotta, Nikolaos E. Bechrakis, Utta Berchner-Pfannschmidt
Summary: Carvedilol, a non-selective β-blocker, has shown anti-tumor properties against UM cells in vitro. The concurrent treatment of carvedilol and irradiation resulted in additive cytotoxic effects. Carvedilol and its enantiomers may be candidates for co-adjuvant therapy of UM.
Article
Biochemical Research Methods
Bilal Ahmad Malla, Sunitha Ramanjeneya, Jess Vergis, Satyaveer Singh Malik, Sukhadeo Baliram Barbuddhe, Deepak Bhiwa Rawool
Summary: The results of this study indicate that the synthetic LLO-2 peptide serves as an ideal diagnostic antigen in serodiagnosis of caprine and ovine listeriosis, showing less cross-reactivity and good diagnostic efficacy.
JOURNAL OF MICROBIOLOGICAL METHODS
(2021)
Review
Biochemistry & Molecular Biology
Marko Anderluh, Francesco Berti, Anna Bzducha-Wrobel, Fabrizio Chiodo, Cinzia Colombo, Federica Compostella, Katarzyna Durlik, Xhenti Ferhati, Rikard Holmdahl, Dragana Jovanovic, Wieslaw Kaca, Luigi Lay, Milena Marinovic-Cincovic, Marco Marradi, Musa Ozil, Laura Polito, Jose Juan Reina, Celso A. Reis, Robert Sackstein, Alba Silipo, Urban Svajger, Ondrej Vanek, Fumiichiro Yamamoto, Barbara Richichi, Sandra J. van Vliet
Summary: Vaccination is a major achievement in preventing infectious diseases, but challenges remain for pathogens with highly variable antigens and in inducing T-cell immunity in cancer. The recent outbreak also highlights the importance of designing smart therapeutic vaccines.
Article
Chemistry, Inorganic & Nuclear
Itziar Galarreta-Rodriguez, Lourdes Marcano, Idoia Castellanos-Rubio, Izaskun Gil de Muro, Isabel Garcia, Luca Olivi, M. L. Fernandez-Gubieda, Ainara Castellanos-Rubio, Luis Lezama, Idoia Ruiz de Larramendi, Maite Insausti
Summary: The preparation of Fe3-xGaxO4 system aims to enhance the understanding of the magnetic response of Ga3+-doped magnetite for MRI contrast agent applications. Monodisperse nanoparticles with different amounts of gallium were prepared and thoroughly characterized to study the influence of gallium doping on the structural, morphological, and magnetic properties of the system. The results showed a clear dependence of magnetic saturation on gallium content and the potential for Fe3-xGaxO4@PMAO nanoparticles with moderate gallium content to act as contrast agents.
DALTON TRANSACTIONS
(2022)
Article
Infectious Diseases
Vicente Soriano, Carmen Alvarez, Benson Edagwa, Carmen de Mendoza, Noemi Montoya, Ana Trevino, Howard Gendelman
Summary: Viral hepatitis is a significant global cause of mortality, with 1.4 million deaths each year. Hepatitis B and C account for 90% of these deaths, and the World Health Organization aims to eliminate viral hepatitis as a public health threat by 2030. While current antivirals can suppress viral replication, they cannot eliminate the virus from infected patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Claudia Feriotti, Joana Sa-Pessoa, Ricardo Calderon-Gonzalez, Lili Gu, Brenda Morris, Ryoichi Sugisawa, Jose L. Insua, Michael Carty, Amy Dumigan, Rebecca J. Ingram, Adrien Kissenpfening, Andrew G. Bowie, Jose A. Bengoechea
Summary: Klebsiella pneumoniae uses SARM1 protein to counteract host immunity and regulate inflammation and MAP kinase activation. Inhibiting SARM1 may be beneficial for treating Klebsiella infections.
Article
Microbiology
Ricardo Calderon-Gonzalez, Alix Lee, Guillermo Lopez-Campos, Steven J. Hancock, Joana Sa-Pessoa, Amy Dumigan, Ronan McMullan, Eric L. Campbell, Jose A. Bengoechea
Summary: Klebsiella pneumoniae is a significant cause of infections, especially antibiotic-resistant ones. It colonizes the nasopharynx and gastrointestinal tract without symptoms, but colonization of the gut is essential for infection. A new murine model has been developed to study gastrointestinal colonization without tissue dissemination, providing insights into the disease dynamics of K. pneumoniae and its colonization resistance.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Roberto C. Delgado Bolton, Adriana K. Calapaqui Teran, Jose Javier Gomez Roman, Giorgio Treglia, Francesco Giammarile
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cell Biology
Marcin Baran, Claudia Feriotti, Aoife McGinley, Simon R. Carlile, Zhaozhao Jiang, Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sa-Pessoa, Caroline E. Sutton, Jay Kearney, Rachel M. McLoughlin, Kingston H. G. Mills, Katherine A. Fitzgerald, Jose A. Bengeochea, Andrew G. Bowie
Article
Materials Science, Multidisciplinary
German Lanzavecchia, Joel Kuttruff, Andrea Doricchi, Ali Douaki, Krishnadas Kumaranchira Ramankutty, Isabel Garcia, Lyuye Lin, Alba Viejo Rodriguez, Thomas Wagberg, Roman Krahne, Nicolo Maccaferri, Denis Garoli
Summary: Plasmonic solid-state nanopores with tunable hole diameters can be prepared using a photocatalytic effect caused by the enhanced electromagnetic field inside a metallic ring on top of a dielectric nanotube. This approach enables the reduction of the initial inner diameter of the nanopore and allows for optimized detection of single entities with different sizes, such as double stranded DNA and gold nanoparticles. Numerical simulations show that a field intensity enhancement of up to 10^4 can be achieved inside the nanopores, which can be used for enhanced optical measurements and local heating.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sara Marcos Gonzalez, Emilio Rodrigo Calabia, Ignacio Varela, Michal Cervienka, Javier Freire Salinas, Jose Javier Gomez Roman
Summary: This study found a high rate of genetic variations in extracellular matrix glycoproteins and adhesion molecules in patients with primary FSGS. These variations may contribute to a susceptible genetic background and the development of glomerulopathy.
Article
Polymer Science
Laura Vespignani, Marco Bonanni, Marco Marradi, Benedetto Pizzo, Roberto Bianchini, Giacomo Goli
Summary: The potential application of naturalized dyes (NDs) in dyeing wood was investigated in this study. Different methods were employed to analyze the dyeing behavior of NDs on wood, including penetration, covering capacity, and color homogeneity. The results showed that NDs could form a uniform coating on wood surfaces when applied as water solutions and exhibited good resistance to color washout, but they showed limited resistance to fading under UV radiations.
Article
Medicine, General & Internal
Inmaculada Ruiz-Caceres, Teresa Hermida Romero, Isabel Guerra Merino, Joseba Portu Zapirain, Belen Perez-Mies, Matilde Sanchez-Conde, Marina Alonso Riano, Rafael Rubio, Jose Fortes Alen, Anxela Vidal Gonzalez, Clara Salas Anton, Elena Munez, Rafael Sanchez Sanchez, Diana Corona-Mata, Iban Aldecoa Ansorregui, Jose M. Miro, Raquel Beloqui Perez de Obanos, Carlos Ibero, Javier Gomez-Roman, M. Carmen Farinas, Teresa Tabuyo Bello, Enrique de Alava, Jose Miguel Cisneros, Xavier Matias-Guiu, Antonio Rivero, NECROCOVID Study Grp
Summary: This study analyzed 70 COVID-19 autopsies and found that most patients had comorbidities before COVID-19 diagnosis, with vascular risk factors being the most common. Infectious complications occurred in 65.71% of the patients during follow-up. Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis, and pre-infection arteriosclerosis in the heart and kidneys.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Javier Freire, Pilar Garcia-Berbel, Belen Caramelo, Lucia Garcia-Berbel, Victor J. Ovejero, Nuria Cadenas, Ainara Azueta, Javier Gomez-Roman
Summary: This study demonstrates that COL11A1 immunostaining is an accurate predictive marker of tumor infiltration in small biopsies of breast, colon, bladder, and ovarian cancer.
Correction
Oncology
Dolores Isla, Maria D. Lozano, Luis Paz-Ares, Clara Salas, Javier de Castro, Esther Conde, Enriqueta Felip, Javier Gomez-Roman, Pilar Garrido, Ana Belen Enguita
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Dolores Isla, Maria D. Lozano, Luis Paz-Ares, Clara Salas, Javier de Castro, Esther Conde, Enriqueta Felip, Javier Gomez-Roman, Pilar Garrido, Ana Belen Enguita
Summary: Non-small cell lung cancer (NSCLC) has the most therapeutic targets, and detecting mutations and translocations, as well as expression of specific biomarkers, is essential for optimal treatment. Next-generation sequencing enables precise molecular diagnosis and identification of emerging mutations and predictive biomarkers. A group of experts in NSCLC diagnosis and treatment from Spain has evaluated available information and proposed recommendations for the detection and use of biomarkers in clinical practice.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Letter
Oncology
Jose-Fernando Val-Bernal, Jose-Javier Gomez-Roman, Marta-Maria Mayorga-Fernandez
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
