Journal
MUSCLE & NERVE
Volume 57, Issue 1, Pages E38-E45Publisher
WILEY
DOI: 10.1002/mus.25674
Keywords
diffusion tensor imaging; FK506; immunomodulation; peripheral nerve injuries; toll-like receptors
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Funding
- National Natural Science Foundation of China [81371607, 81571739]
- Medical Scientific Research Foundation of Guangdong Province of China [A2016117]
- Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital [J201403]
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Introduction: The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis. Methods: Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8-week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate-buffered saline (PBS) alone. Results: Nerves treated with immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS. Discussion: Nerves treated with immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values.
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