HIGH-RESOLUTION MANOMETRY IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY: ELEVATED PREVALENCE OF ESOPHAGEAL INVOLVEMENT AND DIFFERENCES ACCORDING TO AUTOANTIBODY STATUS AND CLINICAL SUBSET

Introduction: In this study we assessed high-resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis. Methods: From 2008 to 2015, we performed a cross-sectional study of myositis patients. A survey of esophageal symptoms and HRM data were analyzed and compared among different clinical and serologic groups. Results: Twenty-four (45%) of the 53 patients included in the study had manometric involvement that was not correlated with any esophageal symptom (P = 0.8). Failed waves (34% vs. 0%, P = 0.004) and decreased upper esophageal sphincter pressure (50 vs. 70mm Hg, P = 0.03) were more common in polymyositis than in dermatomyositis patients. Jackhammer esophagus was more common in anti-TIF1-gamma patients (30% vs. 9%, P = 0.04), and lower esophageal sphincter involvement (47% vs. 25%, P = 0.03) was more prevalent in patients with the anti-synthetase syndrome. Conclusions: Esophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features.