Journal
MOVEMENT DISORDERS
Volume 32, Issue 5, Pages 757-768Publisher
WILEY
DOI: 10.1002/mds.26930
Keywords
cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity
Categories
Funding
- Central European Institute of Technology (CEITEC) [LQ1601]
- Ministry of Education, Youth and Sports of the Czech Republic under the National Sustainability Programme II
- program Investissements d'avenir [ANR-10-IAIHU06, ANR-11-INBS-0006]
- COST Action [BM1101]
- Agence Nationale de la Recherche (ANR) [ANR-11-INBS-0006] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available