Synthesis and antimicrobial activity of bis(azolyl)quinazoline-2,4-diamines

Some new bis(azolylamino)- and bis(azolylmethylamino)quinazolines were prepared from 2,4-dichloroquinazoline and azolyl amines under ultrasonication and tested for their antimicrobial activity. The chloro-, bromo-, and nitro-substituted bis(thiazolylamino)quinazolines displayed excellent antibacterial activity against Bacillus subtilis whereas unsubstituted, chloro-, bromo-, and nitro-substituted bis(imidazolylamino)quinazolines exhibited excellent antifungal activity against Aspergillus niger. [GRAPHICS] .