Review
Cell Biology
Sonja K. Soo, Zenith D. Rudich, Bokang Ko, Alibek Moldakozhayev, Abdelrahman AlOkda, Jeremy M. Van Raamsdonk
Summary: While aging was once considered as a stochastic process of damage accumulation, recent studies have shown that genetics plays a significant role in the aging process. Long-lived genetic mutants in model organisms have provided insights into the genetic and molecular mechanisms involved in extending lifespan. These mutants exhibit activation of stress response pathways, leading to enhanced resistance to stressors, and lifespan exhibits a positive correlation with stress resistance. Disruption of stress response pathways inhibits lifespan extension in these mutants and also reduces lifespan in normal animals, indicating the crucial role of stress response pathways in determining lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Jihao Mo, Zhenzhen Zhang, Xiaowei Wang, Miaomiao Wang, Ning Sun, Lei Wang, Meimei Wang
Summary: A high glucose diet extends the lifespan of aged worms dependent on oxidative stress resistance. The highly expressed genes gpdh-1 and col-92 are associated with oxidative stress response in worms fed high glucose diet. Intestinal gpdh-1 is essential for the lifespan extension induced by high glucose diet in aged worms.
Article
Biochemistry & Molecular Biology
Injeong Cho, Hyun-Ok Song, Ha Eun Ji, Sungtae Yang, Jeong Hoon Cho
Summary: BAM15 can reduce neuronal defects and neurodegeneration in aging C. elegans, potentially through mitochondrial uncoupling mechanism.
Article
Biochemistry & Molecular Biology
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui
Summary: This study found that the natural non-nutritive sweetener Reb A can extend the lifespan and healthspan of C. elegans by reducing cellular reactive oxygen species levels and attenuating neutral lipid accumulation with aging. Reb A acts as an effective cellular antioxidant and lowers the ectopic accumulation of neutral lipids, which contributes to its anti-aging effects.
Article
Physiology
Phillip Wibisono, Jingru Sun
Summary: The impact of pathogen infection in a parental generation on the response to the same pathogen in future generations through epigenetic modifications has been studied. Using the nematode Caenorhabditis elegans as a model, it was found that training a lineage of C. elegans against a specific pathogen did not significantly change overall survival, but reduced survival variability between generations. Gene expression analysis revealed reduced variation in a specific transcription factor pathway. The study also reported a repeating pattern of survival times in the control lineage, indicating potential regulation of survival variability between generations. In conclusion, pathogen infection can cause specific phenotypic changes through epigenetic modifications, and there may be a system of epigenetic regulation between generations.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Yao Zhu, Ying Li, Yuechen Wang, Liang Wang, Peng Shi, Xinze Du, Yingchun Zhang, Yuanjian Song, Zuobin Zhu
Summary: Variations in mitochondrial DNA (mtDNA) are associated with phenotypic traits and lifespan, and their regulatory mechanism involves retrograde communication between mitochondria and the nucleus. In Caenorhabditis elegans, the nuclear gene dct-15 interacts with natural variations in mtDNA COX1, affecting cellular function and lifespan.
Article
Pharmacology & Pharmacy
Wu Zeng, An Guo Wu, Xiao-Gang Zhou, Imran Khan, Rui Long Zhang, Hang Hong Lo, Li Qun Qu, Lin Lin Song, Xiao Yun Yun, Hui Miao Wang, Juan Chen, Jerome P. L. Ng, Fang Ren, Si Yu Yuan, Lu Yu, Yong Tang, Guo Xin Huang, Vincent Kam Wai Wong, Sookja Kim Chung, Simon Wing Fai Mok, Da Lian Qin, Hua Lin Sun, Liang Liu, W. L. Wendy Hsiao, Betty Yuen Kwan Law
Summary: With the increase in human lifespan, population aging has become a major global issue. Aging is an irreversible progressive process that affects humans through various factors. Traditional herbal plants have been widely used for anti-aging and modulation of aging-related symptoms due to their safety and polypharmacological potency.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires-daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov
Summary: This study found that vitamin A can extend lifespan, reduce fat accumulation and lipofuscin production, and increase resistance to heat and oxidative stress in Caenorhabditis elegans. This resistance is attributed to the high levels of detoxifying enzymes induced by vitamin A. Additionally, the study found that vitamin A can upregulate the expression of related genes in human cells and mouse liver tissues.
Article
Biology
Osvaldo Villa, Nicole L. Stuhr, Chia-an Yen, Eileen M. Crimmins, Thalida Em Arpawong, Sean P. Curran
Summary: This study identifies the evolutionarily conserved mitochondrial enzyme ALH-6/ALDH4A1 as a predictive biomarker for age-related changes in muscle health. Through Caenorhabditis elegans genetics and gene-wide association scanning, the research uncovers that loss-of-function mutations in alh-6 lead to the age-dependent loss of muscle health in C. elegans, while genetic variants in ALDH4A1 show associations with age-related muscle-related function in humans.
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.
Article
Immunology
Murugesan Pooranachithra, Kanagavel Suruthi, Bhaskar J. Prabhanand, Murali Deepa, Das Shibendu Sekhar, Krishnan Venkateswaran, Gajbhiye Rahul, Velayutham Ravichandiran, Krishnaswamy Balamurugan
Summary: Infection following injury poses a significant threat in wound care management globally, with increased survival observed in worm models infected with Staphylococcus aureus. High throughput proteomic analysis revealed the importance of oxidative phosphorylation and phosphatidylinositol signaling for enhanced survival in wound infected worms. Elevated calcium signals and ROS are proposed to contribute to the survival of infected worms under pathogen stress.
MICROBIAL PATHOGENESIS
(2021)
Article
Cell Biology
Jing Tian, Caroline Geiss, Kim Zarse, Corina T. Madreiter-Sokolowski, Michael Ristow
Summary: Green tea catechins such as EGCG and ECG have been found to extend healthspan and lifespan in Caenorhabditis elegans by inhibiting mitochondrial complex I and temporarily lowering ATP levels, leading to activation of SKN-1 and DAF-16. These catechins also reduce fat content, enhance ROS defense, and ultimately improve overall healthspan through adaptive responses.
Review
Neurosciences
Lei Wang, Laura Bianchi
Summary: Mounting evidence supports the key role of glia in organismal ageing, with neuropeptides released by glia acting long distance to regulate ageing and activate the unfolded protein response (UPR) in C. elegans. This cell-nonautonomous activation of UPR leads to extension of lifespan, suggesting potential for novel anti-ageing therapies.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biology
Meng Huang, Minjie Hong, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng
Summary: The study identified a class of putative histone 3 lysine 9 mono/dimethyltransferase genes mutations that induce synergistic lifespan extension in Caenorhabditis elegans, increasing resistance to oxidative and heat stress, depending on the transcription factor DAF-16. Treatment with a specific inhibitor also resulted in similar effects.
Article
Biotechnology & Applied Microbiology
Yiling Yang, Wenbin Wang, Kefeng Liu, Jie Zhao
Summary: This study developed an antioxidant nanosystem (SOD@MSN) by immobilizing SOD on mesoporous silica nanoparticles (MSNs) and conducted anti-aging experiments using the nematode model. The results showed that SOD@MSN could be effectively internalized by the nematode and protect it against external stress, thus extending its lifespan and healthspan.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Yoonji Jung, Sujeong Kwon, Seokjin Ham, Dongyeop Lee, Hae-Eun H. Park, Yasuyo Yamaoka, Dae-Eun Jeong, Murat Artan, Ozlem Altintas, Sangsoon Park, Wooseon Hwang, Yujin Lee, Heehwa G. Son, Seon Woo A. An, Eun Ji E. Kim, Mihwa Seo, Seung-Jae Lee
Article
Multidisciplinary Sciences
Sangsoon Park, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, Seung-Jae Lee
Article
Multidisciplinary Sciences
Eun Ji E. Kim, Heehwa G. Son, Hae-Eun H. Park, Yoonji Jung, Sujeong Kwon, Seung-Jae V. Lee
Article
Cell Biology
Sangsoon Park, Murat Artan, Dae-Eun Jeong, Hae-Eun H. Park, Heehwa G. Son, Sieun S. Kim, Yoonji Jung, Yunji Choi, Jin I. Lee, Kyuhyung Kim, Seung-Jae V. Lee
Summary: This study identified food-derived chemical signals, such as diacetyl and the odor of lactic acid bacteria, that can influence the lifespan of Caenorhabditis elegans by reducing the activity of DAF-16/FOXO, a life-extending transcription factor. The findings suggest that food-derived odorants may play a role in shortening lifespan through binding to unidentified receptors.
Article
Cell Biology
Yujin Lee, Yoonji Jung, Dae-Eun Jeong, Wooseon Hwang, Seokjin Ham, Hae-Eun H. Park, Sujeong Kwon, Jasmine M. Ashraf, Coleen T. Murphy, Seung-Jae Lee
Summary: Genetic inhibition of the DAF-2/insulin/IGF-1 receptor in Caenorhabditis elegans can enhance immunocompetence in old age by up-regulating anti-aging transcription factors and preventing immune aging. This study may lead to the development of strategies against immune aging in humans, as many functions are conserved across phyla.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae Lee
Summary: Mutations in the daf-2/insulin/IGF-1 receptor impair growth and reproduction in C. elegans but enhance immunity and lifespan. The authors identified a missense mutation in a gene that retains effects on lifespan and immunity while also improving motility.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Seokjin Ham, Sieun S. Kim, Sangsoon Park, Eun Ji E. Kim, Sujeong Kwon, Hae-Eun H. Park, Yoonji Jung, Seung-Jae V. Lee
Summary: Our study analyzed the relationship between transcriptomic features and physiological and chronological aging using Caenorhabditis elegans as a model. We found that noncoding RNAs and intron-derived transcripts were up-regulated with chronological aging, while mRNAs with many biological functions were down-regulated with physiological aging. Additionally, an increase in the usage of distal 3' splice sites in mRNA transcripts was identified as a biomarker for physiological aging.
Article
Multidisciplinary Sciences
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee
Summary: Mitochondrial Krebs cycle plays a crucial role in immunity, and the genetic inhibition of mitochondrial aconitase can enhance immunity against pathogenic bacteria.
NATURE COMMUNICATIONS
(2023)
