Journal
MOLECULES
Volume 22, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/molecules22071171
Keywords
8-OMe ciprofloxacin; hybrids; synthesis; antimycobacterial; antibacterial
Funding
- NSFC [81373267]
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A series of novel 8-OMe ciprofloxacin (CPFX)-hydrazone/azole hybrids were designed, synthesized, and evaluated for their in vitro biological activities. Our results reveal that all of the hydrozone-containing hybrids (except for 7) show potency against Mycobacterium tuberculosis (MTB) H(37)Rv (minimum inhibitory concentration (MIC): <0.5 mu M), which is better than the parent drug CPFX, and comparable to moxifloxacin and isoniazid, some of the tested Gram-positive strains (MIC: 0.06-4 mu g/mL), and most Gram-negative strains (MIC: <0.03-4 mu g/mL).
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