Article
Plant Sciences
Cheng-Tin Lin, Yao-Hung Yang, Jing-Jy Cheng, Ming-Jaw Don
Summary: This study presents the efficient syntheses of ugonstilbenes A, B, and C using the Horner-Wadsworth-Emmons reaction. The absolute configurations of ugonstilbenes A and C were determined to be R, while ugonstilbene B had the absolute configuration of 4aS,9aR. The synthesized compounds exhibited cytotoxic activities against specific human cancer cell lines.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Chin-Horng Su, Ya-Chih Chen, Ya-Hui Yang, Chun-Yi Wang, Po-Wei Ko, Peng-Ju Huang, Chih-Chuang Liaw, Wen-Ling Liao, Tsung-Lin Cheng, Der-Yen Lee, Lun-Chien Lo, Ching-Liang Hsieh
Summary: This study investigated the effect of oral administration of Helminthostachys zeylanica (HZ) on functional recovery in patients with ankle fractures. The results showed that HZ can increase serum PINP levels and reduce radiographic healing time, indicating its potential therapeutic use in patients requiring surgical treatment for ankle fractures.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Ming-Ming Tsai, Horng-Chyuan Lin, Ming-Chin Yu, Wan-Jung Lin, Mei-Yi Chu, Ching-Ching Tsai, Ching-Yi Cheng
Summary: Our study found that the extract of Helminthostachys zeylanica (E2) has potential as a novel adjunctive agent for the treatment of gastric cancer by inducing apoptosis, increasing autophagy, inhibiting cell proliferation, cell cycle arrest, and suppressing cell migration in gastric cancer cells.
Article
Chemistry, Multidisciplinary
Jiayang Yan, Zhongmin Tang, Yanan Li, Han Wang, Jessica C. Hsu, Mengmeng Shi, Zi Fu, Xiuru Ji, Weibo Cai, Dalong Ni, Jieming Qu
Summary: This study developed molybdenum nanodots as a functional nanomaterial for the treatment of acute lung injury. Through scavenging reactive oxygen species and inhibiting inflammatory responses, the nanodots significantly improved the condition of mice with acute lung injury and protected lung tissues. The findings offer a promising therapeutic agent for patients suffering from acute respiratory disease syndrome.
Review
Microbiology
Xin Zhou, Youxia Liao
Summary: The pathogenesis of septic ALI/ARDS is complex and multifactorial, mainly due to systemic and local inflammatory responses caused by various factors disrupting immune homeostasis, which can initiate and exacerbate ALI/ARDS.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Bohao Liu, Ruyuan He, Lin Zhang, Bo Hao, Wenyang Jiang, Wei Wang, Qing Geng
Summary: Acute lung injury is a critical respiratory disorder with high mortality rates characterized by diffuse cell injury and inflammatory response. Pyroptosis, as a form of cell death, plays a role in immune response by clearing infected cells and promoting wound healing.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Sarah W. Robison, JinDong Li, Liliana Viera, Jonathan P. Blackburn, Rakesh P. Patel, J. Edwin Blalock, Amit Gaggar, Xin Xu
Summary: In acute inflammation, the peptides Proline-glycine-proline and its acetylated form are actively transported from the lung by the oligopeptide transporter PEPT2, leading to increased levels of these peptides in the lung and enhanced lung inflammation. Blocking the PEPT2 transporter may serve as a potential therapeutic target to modulate acute inflammation.
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ramona D'amico, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Stefano Coaccioli, Tiziana Genovese, Daniela Impellizzeri, Rosanna Di Paola, Salvatore Cuzzocrea
Summary: Acute lung injury (ALI) is a common and devastating clinical disorder with a high mortality rate and no specific therapy. The aim of this study was to evaluate the protective effects of Adelmidrol (ADM) in a mice model of ALI induced by lipopolysaccharide (LPS). ADM administration reduced lung damage, airway infiltration, and oxidative stress by regulating mast cells and antioxidant enzymes. These findings suggest that ADM could be a potential candidate in the management of ALI.
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Article
Pharmacology & Pharmacy
Laetitia Pouzol, Anna Sassi, Nadege Baumlin, Melanie Tunis, Daniel S. Strasser, Francois Lehembre, Marianne M. Martinic
Summary: The loss of control in immune cell trafficking to inflamed lung tissue leads to ALI/ARDS. The paper investigates the pathological role of the CXCR3/CXCR4/CXCR7 axis in a murine model of ALI. The study suggests the clinical potential of the CXCR7 antagonist, ACT-1004-1239, in reducing inflammation and improving lung function in ALI/ARDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alyssa Elmore, Ali Almuntashiri, Xiaoyun Wang, Sultan Almuntashiri, Duo Zhang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases. Surfactant protein-D (SP-D) has been extensively studied and found to have superior discriminatory ability for the diagnosis of ARDS. Recombinant SP-D shows potential as a drug for the treatment of ALI.
Article
Critical Care Medicine
Haruka Hashimoto, Takeshi Yoshida, Andi Muhammad Fadlillah Firstiogusran, Hiroki Taenaka, Ryota Nukiwa, Yukiko Koyama, Akinori Uchiyama, Yuji Fujino
Summary: Patient-ventilator asynchrony during mechanical ventilation may lead to lung and diaphragm injury. Breath stacking has a more detrimental effect on oxygenation, lung compliance, and lung injury compared to assist control, while reverse triggering predominantly causes diaphragm injury. Therefore, careful monitoring and management of patient-ventilator asynchrony is crucial in minimizing lung and diaphragm injury in ARDS patients.
CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yaeko Hashimoto, Akifumi Eguchi, Yan Wei, Hiroyo Shinno-Hashimoto, Yuko Fujita, Tamaki Ishima, Lijia Chang, Chisato Mori, Takuji Suzuki, Kenji Hashimoto
Summary: This study investigated the impact of antibiotic-induced microbiome depletion on LPS-induced acute lung injury (ALI). The results showed that antibiotic treatment significantly attenuated LPS-induced lung injury and altered the diversity of the gut microbiota. Additionally, potential microbial markers and plasma metabolites associated with the ABX + LPS group were identified. Network analysis revealed correlations between IL-6 levels in bronchoalveolar lavage fluid (BALF) and specific gut microbes (or plasma metabolites).