Article
Biochemistry & Molecular Biology
Xiao Ye, Yue Wang, Qianwen Chen, Qingmei Feng, Ting Liu, Weihong Feng, Yaohua Liang, Xiaoqian Liu, Chun Li, Zhimin Wang
Summary: Fifteen undescribed diterpenoid alkaloids and seven known analogs were isolated from Aconitum tanguticum. Their structures were determined using spectroscopic methods. The compounds exhibited inhibitory effects on the secretion of NO and TNF-alpha in LPS-treated RAW 264.7 cells, with IC50 values ranging from 67.56 mu M to 683.436 mu M.
Article
Biochemistry & Molecular Biology
Ya Li, Jun Zeng, Yu-hua Tian, Yanan Hou, Honghong Da, Jianguo Fang, Kun Gao
Summary: A study isolated 25 diterpenoid alkaloids from Aconitum sinomontanum, including six newly described ones. Some of these compounds showed significant inhibitory effects on the activity of certain cells.
Article
Chemistry, Medicinal
Junjie Wang, Huayong Lou, Jinyu Li, Ying Liu, Hongping Han, Zaichang Yang, Weidong Pan, Zhi Chen
Summary: Six new C19-aconitine-type diterpenoid alkaloids, named pendulumines A-F, were isolated from the rhizomes of Aconitum pendulum, along with six known compounds. These isolates were tested for their analgesic activity, and one compound showed significant biological activity.
Article
Pharmacology & Pharmacy
Liuying Mao, Baolong Jin, Lingli Chen, Mei Tian, Rui Ma, Biwei Yin, Haiyan Zhang, Juan Guo, Jinfu Tang, Tong Chen, Changjiangsheng Lai, Guanghong Cui, Luqi Huang
Summary: This study provides a comprehensive view of the A. carmichaelii transcriptome by using a combination of Pacbio isoform sequencing and RNA sequencing, identifying 19 TPSs and five alternative splicing isoforms belonging to TPS-b, TPS-c, and TPS-e/f subfamilies. In vitro enzyme reaction analysis functionally identified two sesqui-TPSs and twelve diTPSs. The data clarified ent-CPP as the sole precursor to all DAs biosynthesis, with multiple genes responsible for different types of DAs biosynthesis in A. carmichaelii, laying the foundation for further exploration of the C-20-DAs biosynthetic pathway in the Aconitum species.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Plant Sciences
Anmol, Surekha Kumari, Rakesh Kumar, Raman Singh, Gaurav Aggarwal, Prakhar Agrawal, Dinkar Sahal, Upendra Sharma
Summary: This study provides evidence for the traditionally medicinal use of Aconitum heterophyllum in treating malaria. The chloroform fraction of the roots was found to have the highest anti-plasmodial activity, attributed to the presence of the compound 2-O-cinnamoyl hetisine. Additionally, a new UHPLC-DAD analytical method was developed for quantification of marker compounds and quality assessment of this medicinal plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yana Shi, Yi Zhao, Junxiang Qian, Zhiyuan Dong, Guosong Wen, Dake Zhao, Edward J. Kennelly
Summary: This study identified four important markers in Aconitum carmichaelii and 15 markers to differentiate it from adulterant species. Mesaconitine and hypaconitine were found to be the principal toxins in fuzi, while fuziline and benzoylmesaconine were associated with its medicinal properties. The detection of additional marker compounds in other Aconitum species can be useful in identifying adulteration.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Plant Sciences
Honglin Tao, Xianfeng Liu, Ruimin Tian, Yue Liu, Yong Zeng, Xianli Meng, Yi Zhang
Summary: Aconitum medicinal materials, such as Wutou and Caowu, have great medicinal value but high toxicity. Through complex processing, highly toxic ester diterpenoid alkaloids are hydrolyzed into less toxic aminoalcohol-diterpenoid alkaloids (ADAs). ADAs have low toxicity, are widely distributed in the body, and possess various pharmacological activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nurfida Ablajan, Bo Zhao, Jiang-Yu Zhao, Bian-Lin Wang, Sh Sh Sagdullaev, H. A. Aisa
Summary: Seven new diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum, including two with unprecedented carbon skeletons. The structures of these compounds were determined through comprehensive spectroscopic analysis, and the biogenesis pathways of two of them were discussed. Additionally, the antiarrhythmic, cytotoxic, and antimicrobial activities of the isolates were evaluated.
Review
Plant Sciences
Honglin Tao, Xianfeng Liu, Ruimin Tian, Yue Liu, Yong Zeng, Xianli Meng, Yi Zhang
Summary: This review summarizes the pharmacokinetic and pharmacological activities of low-toxicity aminoalcohol-diterpenoid alkaloids (ADAs), providing a reference for future ADAs research and drug development.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Organic
Lili Qin, Feng Xing, Lin Chen, Xianli Zhou
Summary: In this study, a new denudatine-type C-20-diterpenoid alkaloid named arcutisine was isolated from the roots of Aconitum fischeri var. arcuatum, along with 24 known compounds. The structures were elucidated through spectroscopic analyses. The isolation of compounds 1 and 2 from natural sources for the first time, and the weak anti-inflammatory activity of compounds 7 and 10 at a concentration of 40 μM were notable findings.
Article
Chemistry, Applied
Zhen-Ling Wan, Min Zhang, Yan Xiao, Lin Chen, Jiang Xie, Shuai Huang, Xian-Li Zhou
Summary: Two unprecedented aconitine-type C19-diterpenoid alkaloids, named refractines A-B (1-2), were isolated from the roots of Aconitum refractum. In addition, 12 known compounds (3-14) were also identified. The structures of these compounds were determined through extensive spectroscopic analyses. The inhibitory activities of all compounds against NO production in LPS induced RAW 264.7 macrophages were tested, and compounds 10 and 14 showed slight inhibition with rates of 29.4% and 22.1% at a concentration of 30 μM, respectively.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ashraf M. A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough
Summary: Norditerpenoid alkaloids (NDA) are complex natural products with important pharmacological activities. Research has shown that understanding the metabolism of NDA is crucial for their development as drugs.
NATURAL PRODUCT REPORTS
(2022)
Article
Plant Sciences
Feng Xing, Jiang Xie, Yan-Yan Luo, Shuai Huang, Feng Gao, Lin Chen, Xian-Li Zhou
Summary: Three new aconitine-type C19-diterpenoid alkaloids were isolated from the roots of Aconitum richardsonianum Lauener, along with seventeen known compounds. Some of the isolated compounds showed weak anti-neuroinflammatory effects.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
JiSuk Lee, YoungChul Bae, Nam Jae Kim, Sabina Lim, Young-Mi Kim, Jinwoong Kim, Young-Won Chin
Summary: This study demonstrated the anti-rheumatic effects of A. jaluense tubers in acute and chronic arthritis rats, showing potential for controlling pain and psychiatric symptoms associated with arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Organic
Shuai Huang, Yuming Feng, Jiali Ren, Chuanlun Yang, Lin Chen, Xianli Zhou
Summary: In this study, four new diterpenoid alkaloids were isolated from the roots of Aconitum rockii, including three C-19-diterpenoid alkaloids and one C-20-diterpenoid alkaloid. Compound 13 showed highly potent antifeedant activity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
