Article
Agriculture, Multidisciplinary
Ruiyuan Liu, Zhuangzhuang Li, Sifan Liu, Jinshuo Zheng, PanPan Zhu, Bin Cheng, Ruijin Yu, Huiling Geng
Summary: A series of simple diarylhydrazide derivatives were designed, prepared, and screened for their antifungal activities. The most active compound, 2c, showed significant activity against various plant pathogens in vitro and in vivo. Furthermore, 2c demonstrated no toxicity towards cowpea seed germination and normal human hepatocytes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang, Ying-Qian Liu, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan
Summary: This study synthesized and tested 30 magnolol derivatives based on natural products, with 11 compounds showing potential antifungal activity against four plant pathogenic fungi. Compound L5 exhibited strong antifungal properties against Botrytis cinerea, suggesting it as a promising candidate for crop protection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tingjunhong Ni, Fei Xie, Liping Li, Yumeng Hao, Xiaochen Chi, Lan Yan, Dazhi Zhang, Yuanying Jiang, Quanzhen Lv
Summary: Compound 16g, identified from a compound library, showed promising antifungal activity against Candida albicans, including fluconazole-resistant strains. It was found that the compound's ability to disrupt the cell wall of C. albicans contributed to its antifungal activity. Compound 16g has the potential to be further investigated as a lead compound.
Article
Biochemistry & Molecular Biology
Moises Giner-Llorca, Francisca Gallego del Sol, Jose F. Marcos, Alberto Marina, Paloma Manzanares
Summary: Antifungal proteins (AFPs) produced by Penicillium expansum showed different antifungal profiles and fruit protection effects. By solving the crystal structure of PeAfpB and designing five PeAfpA::PeAfpB chimeras, researchers found that the man-noproteins determined the protein interaction with the cell wall and its antifungal activity, while the binding to membrane phospholipids did not directly correlate with activity. This work provides insights into the feasibility of modifying protein specificity through rational design of chimeras with biotechnological applicability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Arihiro Iwasaki, Kazuya Teranuma, Naoaki Kurisawa, Yulia Rahmawati, Ghulam Jeelani, Tomoyoshi Nozaki, William H. Gerwick, Kiyotake Suenaga
Summary: The antitrypanosomal linear peptide Iheyamide A (1) isolated from marine cyanobacterium was found to have the C-terminal pyrrolinone moiety as the key pharmacophore for its activity, with longer peptide chains showing stronger antitrypanosomal effects. The newly identified iheyanone (2) displayed weaker antitrypanosomal activity compared to Iheyamide A (1), providing insights for the design of antitrypanosomal drugs.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Applied
Xiang Zhu, Shunshun Chen, Yan Zheng, Yong Zhang, Tom Hsiang, Rong Huang, Jingwei Qi, Tian Gan, Yue Chang, Junkai Li
Summary: A series of novel rhein derivatives were designed, synthesized, and evaluated for their antifungal and insecticidal activities, showing moderate antifungal activity against Rhizoctonia solani and potent insecticidal activity against Spodoptera litura and Tetranychus cinnabarinus. The compounds 3a, 5a, and 3b exhibited the most potent insecticidal activities against S. litura, with mortality rates comparable to the commercial insecticide fipronil. These findings provide valuable insights for the development of these derivatives as natural product-based pesticides in crop protection.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jinfeng Chen, Yimou Yang, Yujie Zhou, Yang Wei, Rui Zhu, Shaojun Zheng
Summary: Efficient agricultural antifungal lead compounds were searched by designing, synthesizing, and evaluating 39 Chimonanthus praecox derivatives. Compounds b15 and b17 were identified as the most promising candidates for further study due to their excellent antifungal activities against Phytophthora infestans and Sclerotinia sclerotiorum, with minimum inhibitory concentrations of 1.95 µg/mL for both pathogens.
Article
Chemistry, Medicinal
Melissa M. Cadelis, Tim Liu, Kenneth Sue, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp
Summary: Antibiotic resistance is a growing global health threat. One approach to overcome this is to discover and develop new antibiotic enhancers that can enhance the efficacy of existing antibiotics against resistant bacteria.
Article
Chemistry, Medicinal
Fei Xie, Yumeng Hao, Liping Li, Ruina Wang, Junhe Bao, Xiaochen Chi, Brian C. Monk, Ting Wang, Shichong Yu, Yongsheng Jin, Dazhi Zhang, Tingjunhong Ni, Lan Yan
Summary: This study describes the design, synthesis, and testing of antifungal triazole analogues with alkynyl-methoxyl side chains. The compounds demonstrated broad-spectrum antifungal activity against various pathogenic fungal species, including fluconazole-resistant strains. They targeted the Cyp51 enzyme involved in ergosterol biosynthesis and exhibited low cytotoxicity and hemolytic activity. Compound 16 showed potent in vivo antifungal efficacy in a G. mellonella infection model.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Agricultural Engineering
Liangliang Han, Libo Zhang, Yuedong He, Lijing Liao, Junde Li, Sheng Xu, Yucheng Zhao, Xiaohong Bian, Yuanzheng Xia
Summary: As a popular medicinal plant, Angelica dahurica has garnered attention in herbal medicine due to its active compounds, furanocoumarins (FCs), which have antioxidant, anti-tumor, and anti-virus activities. However, the enzymes responsible for the biosynthesis of FCs have not been identified. This study screened six prenyltransferase-coding sequences and identified two C-PTs (AdPT1, 2) and one O-PT (AdPT3) that are involved in the conversion of different compounds. The study also conducted structural analysis and mutagenesis experiments, revealing important amino acids for the activity of AdPT1. This study provides insights into the biosynthetic pathways of FCs in A. dahurica for further evolutionary studies.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Junhe Bao, Yumeng Hao, Tingjunhong Ni, Ruina Wang, Jiacun Liu, Xiaochen Chi, Ting Wang, Shichong Yu, Yongsheng Jin, Lan Yan, Xiaomei Li, Dazhi Zhang, Fei Xie
Summary: A series of novel triazole derivatives containing aryl-propanamide side chains were designed and synthesised, and their antifungal activities were evaluated. The compounds exhibited inhibitory effects on the growth of several human pathogenic fungi, including fluconazole-resistant strains. Additionally, structure-activity relationships were studied, and the mechanism of action was investigated through GC-MS analysis and molecular docking studies.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Wei Wang, Jianhua Wang, Furan Wu, Huan Zhou, Dan Xu, Gong Xu
Summary: A series of novel pyrazol-5-yl-benzamide derivatives were designed, synthesized, and evaluated for their antifungal activities. Compound 5IIc showed excellent in vitro and in vivo fungicidal activities, demonstrating its potential as a promising fungicide candidate. Additionally, molecular docking simulation and enzymatic inhibition assay provided insights into the mechanism of action of compound 5IIc.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Yong-Jia Chen, Hua Liu, Shao-Yong Zhang, Hu Li, Kun-Yuan Ma, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang
Summary: Cryptolepine and its derivatives were designed, synthesized, and evaluated for their antifungal activities against four agriculturally important fungi. Compound a3 showed significantly prominent inhibitory activity against B. cinerea, while compound f1 exhibited better activity against R. solani and F. graminearum. In addition, in vivo curative experiment found that the therapeutic action of a3 was comparable to that of the positive control azoxystrobin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Huijun Ma, Anran Qian, Yazhou Zheng, Xin Meng, Ting Wang, Yinyong Zhang, Lulu Sun, Feng Zou, Bomei Zhao, Shuhua Zhang, Dan Zhang, Yushe Yang
Summary: This article investigates the modification of Amphotericin B to improve its therapeutic properties by suppressing self-aggregation. The modified compound 36 exhibits a stronger antifungal efficacy compared to the current optimal derivative, amphamide, with lower self-aggregation propensity and toxicity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Huijun Ma, Anran Qian, Yazhou Zheng, Xin Meng, Ting Wang, Yinyong Zhang, Lulu Sun, Feng Zou, Bomei Zhao, Shuhua Zhang, Dan Zhang, Yushe Yang
Summary: In this study, a bisamidation strategy was applied to improve the therapeutic properties of Amphotericin B (AMB) by suppressing self-aggregation. Modifying the basic amino groups at the C16 amide residue enhanced the activity, while introducing lipophilic fragments reduced toxicity. N-methyl-amino acetyl and amino acetyl moieties at the C3' amide helped maintain fungistatic effectiveness. The modified compound 36 exhibited stronger antifungal efficacy and lower toxicity, making it a promising candidate for further development as a second-generation polyene antifungal agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Zhaohao Zhang, Fan Zhang, Yadong Zhang, Gaobo Xu, Zhenhua Wu, Qingzhu Zhang, Yongliang Li, Huaxiang Yin, Jun Luo, Wenwu Wang, Tianchun Ye
Summary: This Letter proposes a 1M-based TCAM with an ultradense 4F(2) cell area on a single reconfigurable TiN/HZO/IGZO/TiN FE diode. The FE diodes were designed with reconfigured P-N, N-P, and ohmic like junctions for '0', '1', and 'X' storage states, respectively. The memory device showed great potential in area-efficient artificial intelligence processors with typical TCAM functions and a maximum driving on/off ratio of approximately 500.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Jialin Yang, Wenhan Zhou, Chuyao Chen, Jingwen Zhang, Hengze Qu, Yuxi Ji, Li Tao, Zhenhua Wu, Haibo Zeng, Shengli Zhang
Summary: Semiconductors are being considered as potential alternatives to silicon for channels in next-generation electronic devices. The study investigates the electronic and ballistic transport properties of 2-D SiP2, which exhibits anisotropy in both geometric structures and electronic properties. The research demonstrates that SiP2 field-effect transistors (FETs) with underlap configuration and gate lengths of 5-12 nm can meet the goals of International Technology Roadmap for Semiconductors (ITRS) and International Roadmap for Devices and Systems (IRDS), with excellent performance in terms of on-state current, delay time, and power dissipation. The study highlights the great potential of 2-D SiP2 for future competitive electronic devices.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jielong Li, Diwei Liu, Ruizhe Ren, Chuanhong Xiao, Zongjun Shi, Tao Zhao, Min Hu, Yanyu Wei, Zhaoyun Duan, Yubin Gong, Zhenhua Wu
Summary: In this study, a novel improvement on ladder line structure called longitudinally slotted structure is proposed, which increases the cross-sectional area of the electron beam and effective interaction area, thereby significantly improving the output power. The dispersion characteristics and field distribution of the slotted structure are analyzed through numerical and simulation calculations, and the optimal parameters are determined. A 94-GHz 2-D slotted structure EIO is designed and compared with the ladder line, it shows a 52.5% increase in cavity characteristic impedance $\textit{R}$ / $\textit{Q}$ and a 21.1% increase in output power. This new structure is expected to provide a new idea for power enhancement in millimeter-wave and terahertz EIOs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Shaojie Chang, Zhenhua Wu, Diwei Liu, Renbin Zhong, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Min Hu
Summary: A novel method for extracting and amplifying the third harmonic of an electron beam to generate high-power terahertz radiation is presented. This approach utilizes three planar grating structures operating in the backwave region to extract and amplify the electron beam from the fundamental modulation, resulting in an amplified output of the fundamental wave and a high power output of the fundamental triplet frequency. The planar grating structure is easier to machine and assemble compared to conventional harmonic amplifiers and allows for increased electron beam flow rate.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Physics, Condensed Matter
Jiayi Chen, Zhen Wang, Zhenhua Wu, Xiaojing Li
Summary: We investigate the electronic and optical properties of different stacked configurations of bilayer black phosphorus quantum dots. Our results show that the energy levels are influenced by the stacking configurations. The AC-stacked and unsymmetrical AB-stacked black phosphorus bilayers enhance optical transitions and realize dark-to-bright transitions in the absorption spectra. The coupling strength of edge states differs between configurations, providing a feasible approach to modulating the electronic and optical properties of bilayer black phosphorus.
SOLID STATE COMMUNICATIONS
(2023)
Article
Engineering, Electrical & Electronic
Tao Song, Xu Qi, Taotao Mao, Chen Zhang, Jie Huang, Peisheng Liang, Aiqin Wang, Jiao Jiao, Na Yao, Kaichun Zhang, Xiaoqiuyan Zhang, Tao Zhao, Zhenhua Wu, Min Hu, Yanyu Wei, Yubin Gong, Wei Wang, Diwei Liu
Summary: Experimental investigations have been carried out on a 0.66-THz gyrotron, with the magnetic injection gun and the gyrotron beam-wave interaction cavity being designed and optimized. The gyrotron cavity incorporates a traditional three-section design. The experimental results demonstrate stable operation at the second cyclotron harmonic, with the gyrotron operating in the TE14,5 mode and a pulselength of 80 mu s. By adjusting the beam energy and magnetic field, the gyrotron achieves a maximum frequency of 656.95 GHz and an output power of 282 W. Additionally, the gyrotron can be used as a frequency-tunable source, with a tunable range of approximately 70 MHz. This gyrotron is specifically designed for irradiating THz waves on living bodies.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jielong Li, Zhenhua Wu, Diwei Liu, Wei Wang, Tao Zhao, Renbin Zhong, Zongjun Shi, Kaichun Zhang, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Shenggang Liu, Min Hu
Summary: A novel high-frequency structure was proposed, which involved vertically placing four conventional ladder-line slow wave structures to form a four-sheet-beam orthogonal interconnection structure. The simulation results showed the achievement of an output power of over 500 W for a 0.22-THz wave with four sheet beams at 16.6 kV and each current of 0.8 A. This structure provides an alternative for the development of terahertz EIOs.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Jiali Huo, Zhaohao Zhang, Yadong Zhang, Fan Zhang, Gangping Yan, Guoliang Tian, Haoqing Xu, Guohui Zhan, Gaobo Xu, Qingzhu Zhang, Huaxiang Yin, Zhenhua Wu
Summary: In this work, ferroelectric field effect transistors (FeFETs) are demonstrated by integrating the ferroelectric Hf0.5Zr0.5O2 (HZO) gate insulator and 2-D ferroelectric semiconductor alpha-In2Se3 channel. These FeFETs feature enhanced large memory windows (MWs) and ultrahigh-speed. The results show that FeFETs have considerable potential in ultra-fast nonvolatile memory (NVM) applications.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Haoqing Xu, Jiaxin Yao, Zhizhen Yang, Lei Cao, Qingzhu Zhang, Yongliang Li, Anyan Du, Huaxiang Yin, Zhenhua Wu
Summary: This article presents a physics-based simulation study of a Si-core-SiGe-shell gate-all-around nanosheet FET. The study evaluates the effect of various factors on electrostatics and transport properties and suggests that the proposed core-shell structure is a potential candidate for advanced technology nodes.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Oncology
Zhe Gong, Yanqiu Zhang, Yue Yang, Yanan Yang, Jieyun Zhang, Yixuan Wang, Liqin Zhao, Nuoya Yu, Zhenhua Wu, Weijian Guo
Summary: Long noncoding RNAs (lncRNAs) have been recently found to play a key role in various types of cancer. In this study, we identified a lncRNA LINC01094 that is associated with the metastasis of gastric cancer (GC) through next-generation sequencing. High expression of LINC01094 is linked to advanced T and N stages and poor prognosis in GC patients. We demonstrated that LINC01094 promotes the proliferation and metastasis of GC both in vitro and in vivo. Furthermore, we discovered that LINC01094 interacts with AZGP1, leading to downregulation of PTEN expression and activation of the AKT pathway.
Review
Food Science & Technology
Yilan Sun, Xiaowei Xu, Zhenzhen Wu, Hanlin Zhou, Xiaoyu Xie, Qinhua Zhang, Renyi Liu, Jie Pang
Summary: This review summarizes recent advances in konjac glucomannan (KGM), including its structural characterization, formation mechanism, preparation methods, functional properties, and the preservation of aquatic food.
Proceedings Paper
Engineering, Electrical & Electronic
Shihui Qiu, Na Li, Zhenhua Wu, Jianlong Zhao, Hongju Mao
Summary: This platform enables the isolation of tumor cells from WBCs and performs fluorescence in situ hybridization (FISH) in a single chip. The platform offers several advantages: (1) Precise cell isolation based on differences in cell size and protein biomarkers; (2) In situ analysis prevents contamination; (3) Single-cell level FISH analysis for CTCs is achieved; (4) Reagent and time savings; (5) Low costs and automation prospects. Hence, the platform holds potential for single-cell level FISH assays.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Mathematics, Applied
Zhen Wu, Bing Xie, Zhiyong Yu
Summary: This paper discusses the Sobolev type weak solutions of a certain class of second order quasilinear parabolic partial differential equations (PDEs). It provides a probabilistic interpretation for the weak solutions by using a family of coupled forward-backward stochastic differential equations (FBSDEs) that satisfy the monotonous assumption. The existence of weak solutions is proven based on the classical solutions of a family of PDEs approximating the weak solutions of the quasilinear PDEs. The uniqueness of the weak solutions is obtained through the principle of norm equivalence linking FBSDEs and PDEs.
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS
(2023)
Article
Acoustics
Deshi Meng, Lijun Li, Zhenhua Wu
Summary: This study presents the design and experimental validation of acoustic metamaterials with ventilation and broadband asymmetric absorption. An asymmetric absorbing cell (AAC) consisting of detuned Helmholtz resonators connected by sound channels achieves near-perfect sound absorption from the left port, while maintaining a ventilation ratio of 40%. Parallel three-cell asymmetric absorber (PTAA) formed by paralleling three AACs exhibits broadband asymmetric absorption. Additionally, a multi-asymmetric absorber (MAA) with a frequency range of 1000 Hz to 1750 Hz and air circulation capability is designed and fabricated using 3D printing technology.
JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL
(2023)
Article
Computer Science, Interdisciplinary Applications
Yan Wang, Jian Cheng, Yixin Chen, Shuai Shao, Lanyun Zhu, Zhenzhou Wu, Tao Liu, Haogang Zhu
Summary: This paper proposes a Fourier Visual Prompting (FVP) method for Source-Free UDA (SFUDA) in medical image segmentation. By adding a visual prompt to the input target data, the frozen pre-trained model can perform well in the target domain. Experimental results demonstrate that the proposed FVP method achieves better segmentation results compared to existing methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
