Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange

Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs

(2017) Juan P. Cerliani et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates

(2016) Shih-Chi Lou et al.   JOURNAL OF MOLECULAR BIOLOGY

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3

(2016) Jiahn-Haur Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-Dimensional NMR Lineshape Analysis

(2016) Christopher A. Waudby et al.   Scientific Reports

Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors

(2016) Tung-Ju Hsieh et al.   Scientific Reports

NMR assignments of the C-terminal domain of human galectin-8

(2015) Chun-Hao Gerard Liu et al.   Biomolecular NMR Assignments

Unraveling the Folding Mechanism of the Smallest Knotted Protein, MJ0366

(2015) Iren Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparative analysis of the folding dynamics and kinetics of an engineered knotted protein and its variants derived from HP0242 ofHelicobacter pylori

(2015) Liang-Wei Wang et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc

(2015) Tung-Ju Hsieh et al.   PLoS One

Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity

(2013) Elena Ermakova et al.   GLYCOBIOLOGY

Galecto Biotech

(2013) Ken Garber   NATURE BIOTECHNOLOGY

Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8

(2013) Byeong-Won Kim et al.   Nature Communications

A sweet way of sensing danger

(2012) Ju Huang et al.   NATURE

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

(2011) Christian St-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

(2011) Kadhirvel Saraboji et al.   BIOCHEMISTRY

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin

(2011) Irina V. Nesmelova et al.   Biomolecular NMR Assignments

An Integrated Computational Analysis of the Structure, Dynamics, and Ligand Binding Interactions of the Human Galectin Network

(2011) Carlos M. A. Guardia et al.   Journal of Chemical Information and Modeling

The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1

(2011) Fredrik I. Andersson et al.   JOURNAL OF MOLECULAR BIOLOGY

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

(2010) Bader A. Salameh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity

(2010) Irina V. Nesmelova et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis and Evaluation of New Thiodigalactoside-Based Chemical Probes to Label Galectin-3

(2009) Monique van Scherpenzeel et al.   CHEMBIOCHEM

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer

(2008) Irina V. Nesmelova et al.   Biomolecular NMR Assignments