The Antiproliferative Effect of Cyclodipeptides from Pseudomonas aeruginosa PAO1 on HeLa Cells Involves Inhibition of Phosphorylation of Akt and S6k Kinases

Cyclo(phenylalanine-proline) induces DNA damage in mammalian cellsviareactive oxygen species

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mTOR: a pharmacologic target for autophagy regulation

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A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

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Cytotoxicity of Cyclodipeptides fromPseudomonas aeruginosaPAO1 Leads to Apoptosis in Human Cancer Cell Lines

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The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor

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Persistence of microbial communities including Pseudomonas aeruginosa in a hospital environment: a potential health hazard

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Cyclic dipeptides from lactic acid bacteria inhibit proliferation of the influenza a virus

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Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

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Cyclo(d-Tyr-d-Phe): a new antibacterial, anticancer, and antioxidant cyclic dipeptide fromBacillussp. N strain associated with a rhabditid entomopathogenic nematode

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Plan B for quorum sensing

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Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma

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Synthesis and anticancer activity of epipolythiodiketopiperazine alkaloids

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Cyclic dipeptides exhibit potency for scavenging radicals

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mTOR Signaling in Growth Control and Disease

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2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

(2012) Alan D. Borthwick   CHEMICAL REVIEWS

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells

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Nonribosomal Peptide Synthesis in Animals: The Cyclodipeptide Synthase of Nematostella

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Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants

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Mammalian target of rapamycin: Biological function and target for novel anticancer agents

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Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways

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Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence

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New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides

(2009) Jennifer Campbell et al.   ACS Chemical Biology

Hybrid Pathogenicity Island PAGI-5 Contributes to the Highly Virulent Phenotype of a Pseudomonas aeruginosa Isolate in Mammals

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Cancer Cell-Derived Clusterin Modulates the Phosphatidylinositol 3'-Kinase-Akt Pathway through Attenuation of Insulin-Like Growth Factor 1 during Serum Deprivation

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