Article
Biochemical Research Methods
Yao Luo, Guoyi Yu, Fei Liu, Yanwen Feng, Pei Zhao, Jun Yue
Summary: The nontraditional intrinsic fluorescence (NTIF) of polymers containing heteroatoms has been studied for label-free bioimaging applications. Hyper-branched polyureas (aBPUs) with different degrees of branching (DBs) or different modifications were synthesized to investigate their NTIF properties. The results showed that aBPUs exhibited obvious NTIF phenomenon and the NTIF enhanced with the increase of DBs. Chemical modifications and the formation of nanoassembly also affected the NTIF performances.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Biswa Ranjan Swain, Soumya Ranjan Jena, Swaraj Kumar Beriha, Chandra Sekhara Mahanta, Bibhuti Bhusan Jena, Thumpati Prasanth, Luna Samanta, Rashmirekha Satapathy, Barada P. Dash
Summary: Boron-rich glycodendrimers containing multiple glucose moieties and ortho-carborane clusters were synthesized and found to be completely water soluble due to increased hydrophilicity. In vitro evaluation showed that the glycodendrimer with nine glucose moieties exhibited the highest cytotoxicity against MCF-7 breast cancer cells, with a 600-fold higher potency than cisplatin. The study suggests that these glycodendrimers could serve as tumor-specific anticancer agents.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sofia N. Ardabevskaia, Elena S. Chamkina, Irina Yu. Krasnova, Sergey A. Milenin, Ekaterina A. Sukhova, Konstantin L. Boldyrev, Artem V. Bakirov, Olga A. Serenko, Zinaida B. Shifrina, Aziz M. Muzafarov
Summary: The controllable synthesis of novel hybrid dendrimers composed of flexible and rigid components was achieved via a click reaction. Thermal and phase behavior analysis revealed similar performance of dendrimers regardless of the generation of carbosilane cores, possibly due to the similar ratio of rigid and flexible blocks. The annealing procedure confirmed the tendency of hybrid dendrimers to order based on their constituents of different structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yu Zhu, Hanqiu Jiang, Weiwei Wu, Xiao-Qin Xu, Xu-Qing Wang, Wei-Jian Li, Wei-Tao Xu, GengXin Liu, Yubin Ke, Wei Wang, Hai-Bo Yang
Summary: This article presents a novel type of polymer, rotaxane-branched dendronized polymers, with tunable thermal and rheological properties. These polymers have reversible thickness modulation ability and can serve as attractive platforms for the construction of smart polymeric materials.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kseniya A. Bezlepkina, Irina I. Belikova, Vasilissa A. Aristova, Kseniia S. Klokova, Sofia N. Ardabevskaia, Alexander Yu Pereyaslavtsev, Dmitry A. Migulin, Sergey A. Milenin
Summary: This study demonstrates the synthesis of functional organosilicon molecules using CuAAC reaction under heterogeneous catalysis conditions. The reactions were carried out without the use of solvents or amines, and at a relatively low temperature. The leaching of copper ions from the catalyst into the final products was observed, and the potential toxicity of the products towards biological cells was evaluated.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Applied
Lina Mao, Xiao Ren, Bang Feng, Yunlong Zhang, Jing Zhang, Wei Huang
Summary: A new A(A') + B3 approach based on sydnone-maleimide double cycloaddition (SMDC) was investigated for synthesizing hyperbranched polyimides (HBPIs). The method effectively avoided gelation and improved the degree of branching. By adjusting the monomer concentration and feeding modes, HBPIs with moderate molecular weight and low polydispersity could be obtained. Furthermore, the as-synthesized HBPIs exhibited good solubility and thermal stability.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Review
Energy & Fuels
Ying Zhang, Weichu Yu
Summary: This paper provides an overview of the synthesis methods of hyperbranched polymers, analyzing the advantages and disadvantages of different methods. Furthermore, it describes the research progress of hyperbranched polymers in oilfield chemistry and discusses their application advantages and existing problems in various areas. Finally, it forecasts the application prospects of hyperbranched polymers in drilling, oil recovery, and gathering and transportation chemistry.
FRONTIERS IN ENERGY RESEARCH
(2022)
Review
Polymer Science
Zhishuai Geng, Jaeman J. Shin, Yumeng Xi, Craig J. Hawker
Summary: Click chemistry is a powerful strategy for constructing polymeric soft materials with precise control over architecture and functionality. This review provides a comprehensive summary of the state-of-the-art in synthesizing functional polymers and their expanding range of applications, discussing key reactions that fulfill click requirements and their applications in constructing macromolecules with linear, branched, and other complex architectures.
JOURNAL OF POLYMER SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Fernando Garcia-Alvarez, Marcos Martinez-Garcia
Summary: Drug delivery systems are important for targeted delivery and controlled release of medicinal agents. Dendrimers have attracted increasing interest as drug delivery systems due to their properties and structural characteristics. Click chemistry offers efficient approaches for the synthesis of dendritic structures. This review summarizes the recent strategies for building dendrimer drug delivery systems using click reactions from 2015 to early 2021.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Weibin Cai, Shuaiqi Yang, Lunqiang Zhang, Ying Chen, Li Zhang, Jianbo Tan
Summary: Efficient synthesis and self-assembly of segmented hyperbranched block copolymers (SHBCs) were achieved using reversible addition-fragmentation chain-transfer (RAFT)-mediated dispersion polymerization-induced self-assembly (PISA) method. Different synthetic approaches were employed to obtain SHBCs with significant structural differences, and further control over the structure and morphology of SHBCs and SHBC assemblies was achieved.
Article
Polymer Science
Shikha, Josemon Jacob
Summary: In this study, a series of amphiphilic hyperbranched molecules and star polymers were successfully synthesized, and their potential application in dye removal from aqueous waste was demonstrated.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Ayaka Sawada, Yoshimitsu Tachi, Masatoshi Kozaki
Summary: This article investigates two types of dendrimers with a bipyridine unit and successfully synthesizes a trimer with three bipyridine cores through chemical reactions. The addition of Fe(II) ions to the trimer solution leads to the formation of a characteristic folded structure around the metal center.
Article
Infectious Diseases
Hector Manuel Pineda-Castaneda, Mauricio Maldonado-Villamil, Claudia Marcela Parra-Giraldo, Aura Lucia Leal-Castro, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Javier Eduardo Garcia-Castaneda
Summary: Antimicrobial resistance (AMR) poses one of the top ten threats to public health, resulting from the lack of new therapies and/or treatment agents. This study explores the use of resorcinarenes as antimicrobial agents, which have shown antibacterial and antifungal properties and can be used in drug and gene delivery systems. The researchers synthesized (peptide)(4)-resorcinarene conjugates using click chemistry and evaluated their antimicrobial and cytotoxic activities.
Article
Biochemistry & Molecular Biology
Xiaoya Li, Sedef Ilk, Javier A. Linares-Pasten, Yang Liu, Deepak Bushan Raina, Deniz Demircan, Baozhong Zhang
Summary: Nonionic hyperbranched polyesters (HBPs) with indole functionality exhibited significant antibacterial activity and were miscible with biodegradable polyesters, while HBPs with isatin or methylindole were completely immiscible with the same matrices. Molecular docking simulations revealed different orientations of molecules at the active site of PETase due to the presence of indole or isatin groups, which could explain the observed enzymatic degradation behavior. Biocompatibility analysis showed negligible cytotoxic effects of the fabricated HBPs on a mammalian cell line.
Article
Chemistry, Multidisciplinary
Jincai Li, Joseph J. Richardson, Hirotaka Ejima
Summary: This article reports the first synthesis of dithiocatechol-pendant polymers using a novel protection-deprotection strategy. The resulting polymers are soluble in common organic solvents and can be fully characterized by standard spectroscopic methods. The study also demonstrates the possibility of using reversible addition-fragmentation chain-transfer polymerization to synthesize dithiocatechol-pendant polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Jacob P. Quint, Azadeh Mostafavi, Yori Endo, Adriana Panayi, Carina S. Russell, Atousa Nourmahnad, Chris Wiseman, Laleh Abbasi, Mohamadmahdi Samandari, Amir Sheikhi, Kristo Nuutila, Indranil Sinha, Ali Tamayol
Summary: This study presents a novel bioink utilizing nanotechnology and biomaterials for in vivo printing of adhesive and 3D scaffolds to promote muscle injury treatment. The results demonstrate that this technology can facilitate functional muscle recovery, reduce fibrosis, and increase anabolic response.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Ehsan Zeimaran, Sara Pourshahrestani, Ali Fathi, Nasrul Anuar bin Abd Razak, Nahrizul Adib Kadri, Amir Sheikhi, Francesco Baino
Summary: Injectable composite hydrogels based on biodegradable polymers and bioactive glasses have gained attention in tissue engineering. These hydrogels combine the advantages of their constituents to provide tailored mechanical properties and biological functionalities.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Environmental
Patricia Wamea, Mica L. Pitcher, Joy Muthami, Amir Sheikhi
Summary: Rare earth elements are critical in advanced industries, but the world is facing shortages and challenges in sustainable removal. The development of AHNC, a bio-based technology, shows promising results in high-capacity and selective removal of Nd3+ from aqueous media.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Brian McVerry, Alexandra Polasko, Ethan Rao, Reihaneh Haghniaz, Dayong Chen, Na He, Pia Ramos, Joel Hayashi, Paige Curson, Chueh-Yu Wu, Praveen Bandaru, Mackenzie Anderson, Brandon Bui, Aref Sayegh, Shaily Mahendra, Dino Di Carlo, Evgeniy Kreydin, Ali Khademhosseini, Amir Sheikhi, Richard B. Kaner
Summary: A simple surface modification technique has been developed to reduce microbial and protein adhesion on artificial materials, showing promising results in clinical applications. The treated surfaces exhibit strong resistance against adhesion and are non-toxic to cells. Surface-treated catheters have been approved by the FDA and have shown good clinical efficacy in patients.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sarah A. E. Young, Joy Muthami, Mica Pitcher, Petar Antovski, Patricia Wamea, Robert Denis Murphy, Reihaneh Haghniaz, Andrew Schmidt, Samuel Clark, Ali Khademhosseini, Amir Sheikhi
Summary: This study developed a highly efficient cellulose-based nanoadsorbent for capturing chemotherapy drugs with higher drug capture capacity and lower toxicity. The research may pave the way for developing next-generation in vitro and in vivo drug capture additives and devices.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zaman Ataie, Sina Kheirabadi, Jenna Wanjing Zhang, Alexander Kedzierski, Carter Petrosky, Rhea Jiang, Christian Vollberg, Amir Sheikhi
Summary: This study overcomes the limitations of traditional granular hydrogel bioinks in 3D bioprinting by using reversible interfacial nanoparticle self-assembly in the microgels, enabling the fabrication of bioinks with microporous structure. The microporous architecture promotes cell penetration and oxygen transfer, improves cell viability, and facilitates 3D cell seeding.
Article
Nanoscience & Nanotechnology
Shang-Lin Yeh, Naveen Narasimhalu, Landon G. vom Steeg, Joy Muthami, Sean LeConey, Zeming He, Mica Pitcher, Harrison Cassady, Valerie J. Morley, Sung Hyun Cho, Carol Bator, Roya Koshani, Robert J. Woods, Michael Hickner, Andrew F. Read, Amir Sheikhi
Summary: Daptomycin is a cyclic anionic lipopeptide antibiotic used to treat multidrug-resistant Gram-positive bacterial infections. This study reveals the interactions between cholestyramine and Daptomycin, as well as the mechanisms of antibiotic removal from the gastrointestinal tract. The findings suggest the potential of optimizing cholestyramine adjuvant therapy and designing novel biomaterials to prevent antibiotic resistance in off-target populations.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Avijit Baidya, Reihaneh Haghniaz, Gregory Tom, Masoud Edalati, Naoki Kaneko, Parvin Alizadeh, Maryam Tavafoghi, Ali Khademhosseini, Amir Sheikhi
Summary: Shear-thinning hydrogels are biomaterials suitable for catheter-based minimally invasive therapies. However, the tradeoff between injectability and mechanical integrity has limited their applications. By controlling the noncovalent interactions, the cohesion of hydrogels can be significantly enhanced without compromising injectability, thereby enabling complex minimally invasive procedures.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Mica L. Pitcher, Breanna Huntington, Juliana Dominick, Amir Sheikhi
Summary: This study evaluates the potential of an acid-free method to convert various lignocellulosic biomass into highly charged micro-and nano-structured materials. The sequential oxidation of lignocellulosic sources yields different types of nanoparticles with extremely high charge density. These materials show promising applications in removing neodymium ions from dilute solutions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Breanna Huntington, Mica L. Pitcher, Amir Sheikhi
Summary: Enhancing the redispersibility of dried colloidal particles is a challenge in sustainable processing. The researchers proposed a method of adding moieties to cellulose nanocrystals to enable colloidal repulsion, and conducted experiments to verify the improvement in redispersibility.
Article
Multidisciplinary Sciences
Zaman Ataie, Arian Jaberi, Sina Kheirabadi, Aneesh Risbud, Amir Sheikhi
Summary: The emergence of granular hydrogel scaffolds (GHS) allows for degradation-independent cell infiltration and transfer of important substances in tissue engineering. The conversion of bulk GelMA to GHS opens up new opportunities. GHS can be formed via the assembly of GelMA microgels, leading to enhanced mechanical properties.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Chemistry, Multidisciplinary
Sina Kheirabadi, Amir Sheikhi
Summary: Medical waste has increased in the past 3 years due to the COVID-19 pandemic. This situation is expected to worsen as healthcare markets grow and the population ages, posing health threats to the public through environmental impacts. Urgent medical waste management is needed to alleviate these effects.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Physical
Shang-Lin Yeh, Roya Koshani, Amir Sheikhi
Summary: In this study, it was found that the interaction between cationic surfactant and calcium carbonate can reduce the deposition rate, decrease crystal size, and destabilize the emulsion within hours. This fundamental research may provide new opportunities for engineering stable water/oil emulsions and developing scale-resistant multiphase flows.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Reihaneh Haghniaz, Han -Jun Kim, Hossein Montazerian, Avijit Baidya, Maryam Tavafoghi, Yi Chen, Yangzhi Zhu, Solmaz Karamikamkar, Amir Sheikhi, Ali Khademhosseini
Summary: Blood loss from hemorrhaging wounds is a major cause of trauma fatalities, resulting in millions of deaths each year. This study developed biocompatible and biodegradable microneedle arrays (MNAs) that promote rapid blood coagulation for hemorrhage control. By combining gelatin meth-acryloyl (GelMA) biomaterial with silicate nanoplatelets (SNs), these MNAs effectively reduced bleeding by 92% compared to untreated injuries in a rat liver bleeding model. The micro and nanoengineering features of the SN-containing MNAs outperformed needle-free patches and a commercial hemostat, making them suitable for rapid hemorrhage control.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Guillermo U. Ruiz-Esparza, Xichi Wang, Xingcai Zhang, Sofia Jimenez-Vazquez, Liliana Diaz-Gomez, Anne-Marie Lavoie, Samson Afewerki, Andres A. Fuentes-Baldemar, Roberto Parra-Saldivar, Nan Jiang, Nasim Annabi, Bahram Saleh, Ali K. Yetisen, Amir Sheikhi, Thomas H. Jozefiak, Su Ryon Shin, Nianguo Dong, Ali Khademhosseini
Summary: A novel injectable and sprayable shear-thinning hydrogel barrier (STHB) was developed to prevent postoperative adhesions, showing limited cell adhesion and cytotoxicity in vitro and superior efficacy compared to a commercially available adhesion barrier in a rodent model. The technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods.
NANO-MICRO LETTERS
(2021)
