Journal
MOLECULES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules22122067
Keywords
Panax japonicus C; A; Mey; Panacis Japonici Rhizoma; triterpenoid saponin; ginsenoside; chikusetsusaponin; pseudoginsenoside; standardized reference fraction; quantification; quality control; HPLC
Funding
- Research Committee of the University of Macau [MYRG2014-00162-ICMS-QRCM, MYRG2015-00153-ICMS-QRCM]
- National Natural Science Foundation of China [81274023]
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Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR. The strategy is feasible and reliable, and the methodology of the developed approach is also validated. The standardized reference fraction was used for quantification, which might solve the shortage of the pure reference compounds in the quality control of herbal medicines.
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