Magnetic Nanoparticles in the Central Nervous System: Targeting Principles, Applications and Safety Issues

Non-viral vectors based on magnetoplexes, lipoplexes and polyplexes for VEGF gene delivery into central nervous system cells

(2017) Ilia Villate-Beitia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma

(2017) Wen-Chia Huang et al.   JOURNAL OF CONTROLLED RELEASE

Magnetic Nanoparticle-Based Mechanical Stimulation for Restoration of Mechano-Sensitive Ion Channel Equilibrium in Neural Networks

(2017) Andy Tay et al.   NANO LETTERS

Intrathecal magnetic drug targeting for localized delivery of therapeutics in the CNS

(2017) Indu Venugopal et al.   Nanomedicine

Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease

(2017) Faiz Ul Amin et al.   Nanoscale

Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer’s disease

(2017) Célia Faustino et al.   PHARMACOLOGICAL RESEARCH

Ten Things You Might Not Know about Iron Oxide Nanoparticles

(2017) Heike E. Daldrup-Link   RADIOLOGY

Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model

(2017) Shuiqin Niu et al.   Theranostics

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging

(2017) Meaghan Anne O'Reilly et al.   Theranostics

Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice

(2017) Rahul Munshi et al.   eLife

Investigation of ac-magnetic field stimulated nanoelectroporation of magneto-electric nano-drug-carrier inside CNS cells

(2017) Ajeet Kaushik et al.   Scientific Reports

Superparamagnetic Iron Oxide Nanoparticles Modified with Tween 80 Pass through the Intact Blood–Brain Barrier in Rats under Magnetic Field

(2016) Yinping Huang et al.   ACS Applied Materials & Interfaces

Induction of Calcium Influx in Cortical Neural Networks by Nanomagnetic Forces

(2016) Andy Tay et al.   ACS Nano

Development of TIMP1 magnetic nanoformulation for regulation of synaptic plasticity in HIV-1 infection

(2016) Venkata Atluri et al.   International Journal of Nanomedicine

AN in vitro evaluation of a carmustine-loaded Nano-co-Plex for potential magnetic-targeted intranasal delivery to the brain

(2016) Olufemi D. Akilo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Guidance of Magnetic Nanocontainers for Treating Alzheimer's Disease Using an Electromagnetic, Targeted Drug-Delivery Actuator

(2016) Ton Duc Do et al.   Journal of Biomedical Nanotechnology

Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

(2016) Yu Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Nano carriers for drug transport across the blood–brain barrier

(2016) Xinming Li et al.   JOURNAL OF DRUG TARGETING

Neuroprotective Potential of Superparamagnetic Iron Oxide Nanoparticles Along with Exposure to Electromagnetic Field in 6-OHDA Rat Model of Parkinson’s Disease

(2016) Preeti Umarao et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro

(2016) Myosotys Rodriguez et al.   Journal of Neuroimmune Pharmacology

Passage of Magnetic Tat-Conjugated Fe3O4@SiO2 Nanoparticles Across In Vitro Blood-Brain Barrier

(2016) Xueqin Zhao et al.   Nanoscale Research Letters

Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism

(2016) Sarah A. Stanley et al.   NATURE

Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery

(2016) Geoff Appelboom et al.   NEURO-ONCOLOGY

Magnetic nanotherapeutics for dysregulated synaptic plasticity during neuroAIDS and drug abuse

(2016) Vidya Sagar et al.   Molecular Brain

Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations

(2016) Michal Marcus et al.   JOURNAL OF NANOBIOTECHNOLOGY

Passage of Magnetic Tat-Conjugated Fe3O4@SiO2 Nanoparticles Across In Vitro Blood-Brain Barrier

(2016) Xueqin Zhao et al.   Nanoscale Research Letters

Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers

(2016) Ajeet Kaushik et al.   Scientific Reports

A Smart Magnetically Active Nanovehicle for on-Demand Targeted Drug Delivery: Where van der Waals Force Balances the Magnetic Interaction

(2015) Sudipta Panja et al.   ACS Applied Materials & Interfaces

Long-Term Effects of Magnetically Targeted Ferumoxide-Labeled Human Neural Stem Cells in Focal Cerebral Ischemia

(2015) Miyeoun Song et al.   CELL TRANSPLANTATION

Therapeutic approaches of magnetic nanoparticles for the central nervous system

(2015) Fahima Dilnawaz et al.   DRUG DISCOVERY TODAY

Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery

(2015) Joan Estelrich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sustained-release nanoART formulation for the treatment of neuroAIDS

(2015) Rahul Jayant et al.   International Journal of Nanomedicine

Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS

(2015) Vidya Sagar et al.   Journal of Biomedical Nanotechnology

Implant-Assisted Intrathecal Magnetic Drug Targeting to Aid in Therapeutic Nanoparticle Localization for Potential Treatment of Central Nervous System Disorders

(2015) Eric Lueshen et al.   Journal of Biomedical Nanotechnology

Predicting and optimizing the territory of blood–brain barrier opening by superselective intra-arterial cerebral infusion under dynamic susceptibility contrast MRI guidance

(2015) Miroslaw Janowski et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery

(2015) Seyed Nasrollah Tabatabaei et al.   JOURNAL OF CONTROLLED RELEASE

Toward nonsystemic delivery of therapeutics across the blood–brain barrier

(2015) Seyed Nasrollah Tabatabaei et al.   Nanomedicine

Magnetoelectric ‘spin’ on stimulating the brain

(2015) Rakesh Guduru et al.   Nanomedicine

Movement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal function

(2015) Bharath Ramaswamy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enduring high-efficiency in vivo transfection of neurons with non-viral magnetoparticles in the rat visual cortex for optogenetic applications

(2015) Cristina Soto-Sánchez et al.   Nanomedicine-Nanotechnology Biology and Medicine

PO-1068: Characterization of superparamagnetic, oxygen loaded NanoBubbles for hyperthermia and radiotherapy

(2015) S. Zullino et al.   RADIOTHERAPY AND ONCOLOGY

Wireless magnetothermal deep brain stimulation

(2015) R. Chen et al.   SCIENCE

Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge

(2015) Maria Busquets et al.   Nanomaterials

Targeting Cancer Gene Therapy with Magnetic Nanoparticles

(2015) Charles Li et al.   Oncotarget

The potential of magneto-electric nanocarriers for drug delivery

(2014) Ajeet Kaushik et al.   Expert Opinion on Drug Delivery

Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood–brain barrier

(2014) Zhizhi Sun et al.   International Journal of Nanomedicine

Study of amphotericin B magnetic liposomes for brain targeting

(2014) Mengyu Zhao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhanced blood–brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation

(2014) Hong Ding et al.   NANOTECHNOLOGY

Uptake and Metabolism of Iron Oxide Nanoparticles in Brain Cells

(2014) Charlotte Petters et al.   NEUROCHEMICAL RESEARCH

Alternating Magnetic Field-Induced Hyperthermia Increases Iron Oxide Nanoparticle Cell Association/Uptake and Flux in Blood–Brain Barrier Models

(2014) Mo Dan et al.   PHARMACEUTICAL RESEARCH

Brain-Targeted Delivery of Trans-Activating Transcriptor-Conjugated Magnetic PLGA/Lipid Nanoparticles

(2014) Xiangru Wen et al.   PLoS One

Engineered nanoparticles. How brain friendly is this new guest?

(2014) Francesca A. Cupaioli et al.   PROGRESS IN NEUROBIOLOGY

Open challenges in magnetic drug targeting

(2014) Benjamin Shapiro et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells

(2013) L. B. Thomsen et al.   ACS Chemical Neuroscience

Physical energy for drug delivery; poration, concentration and activation

(2013) Shanmugamurthy Lakshmanan et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields

(2013) Chris F. Adams et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study

(2013) Sudheesh Pilakka-Kanthikeel et al.   PLoS One

Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers

(2013) Madhavan Nair et al.   Nature Communications

Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinoma

(2012) Lihong Bu et al.   Contrast Media & Molecular Imaging

Magnetic Field-Assisted Gene Delivery: Achievements and Therapeutic Potential

(2012) Jose I. Schwerdt et al.   CURRENT GENE THERAPY

Magnetic targeting of nanoparticles across the intact blood–brain barrier

(2012) Seong Deok Kong et al.   JOURNAL OF CONTROLLED RELEASE

Nano-sized cationic polymeric magnetic liposomes significantly improves drug delivery to the brain in rats

(2012) Ming Zhao et al.   JOURNAL OF DRUG TARGETING

Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regenerationin vivo

(2012) Richard Sensenig et al.   Nanomedicine

Smart multifunctional core–shell nanospheres with drug and gene co-loaded for enhancing the therapeutic effect in a rat intracranial tumor model

(2012) HanJie Wang et al.   Nanoscale

Magneto-Electric Nano-Particles for Non-Invasive Brain Stimulation

(2012) Kun Yue et al.   PLoS One

Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects

(2011) Christian Plank et al.   ADVANCED DRUG DELIVERY REVIEWS

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Magnetic field-induced acceleration of the accumulation of magnetic iron oxide nanoparticles by cultured brain astrocytes

(2011) Marie-Christin Lamkowsky et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Magnetically targeted nanoparticles for brain tumor therapy: what does the future hold?

(2011) Allan E David et al.   Nanomedicine

Using a Neodymium Magnet to Target Delivery of Ferumoxide-Labeled Human Neural Stem Cells in a Rat Model of Focal Cerebral Ischemia

(2010) Miyeoun Song et al.   HUMAN GENE THERAPY

The behaviors of ferromagnetic nano-particles in and around blood vessels under applied magnetic fields

(2010) A. Nacev et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

(2010) Jean-Baptiste Mathieu et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetic nanoparticle transport within flowing blood and into surrounding tissue

(2010) A Nacev et al.   Nanomedicine

Aptamer conjugated magnetic nanoparticles as nanosurgeons

(2010) Baiju G Nair et al.   NANOTECHNOLOGY

The formulation, characterization andin vivoevaluation of a magnetic carrier for brain delivery of NIR dye

(2010) S L Raut et al.   NANOTECHNOLOGY

Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment

(2010) P.-Y. Chen et al.   NEURO-ONCOLOGY

Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

(2010) H.-L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene transfer using self-assembled ternary complexes of cationic magnetic nanoparticles, plasmid DNA and cell-penetrating Tat peptide

(2009) Hai Peng Song et al.   BIOMATERIALS

Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved Biocompatibility

(2009) Santaneel Ghosh et al.   Nanoscale Research Letters

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

(2007) Beata Chertok et al.   BIOMATERIALS