Journal
MOLECULES
Volume 22, Issue 10, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules22101796
Keywords
aa-tRNAsynthetase; cyclodipeptides; cyclodipeptide synthase; non-ribosomal peptide synthetase; tailoring enzyme
Funding
- Yeungnam University, Gyeongsan, Gyeongbuk , Korea
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Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters. In this review, we provide a comprehensive summary of CDP biosynthetic pathways and modifying enzymes. We also discuss the biological properties of some known CDPs and their possible applications in metabolic engineering.
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