Article
Genetics & Heredity
Xin Li, Haojie Wang, Zhijie Liu, Alimujiang Abudureyimu
Summary: The study showed that circSETD3 was downregulated in hepatoblastoma (HB) and its overexpression inhibited cell proliferation, migration, EMT, and induced apoptosis. Furthermore, circSETD3 positively regulated Bim by sponging miR-423-3p, leading to the inhibition of HB development.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Morales-Pison, Lilian Jara, Valentina Carrasco, Cristian Gutierrez-Vera, Jose Miguel Reyes, Patricio Gonzalez-Hormazabal, Leandro J. Carreno, Julio C. Tapia, Hector R. Contreras
Summary: The rs6505162:A allele plays an important role in mammary tumorigenesis by promoting breast cancer cell proliferation, chemoresistance, migration, invasion, and inhibiting apoptosis. This finding may have implications for early diagnosis, prognosis, and treatment of breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zengxi Yang, Xi OuYang, Liang Zheng, Lizhen Dai, Wenjuan Luo
Summary: In this study, it was found that LINC00265 is significantly upregulated in gastric cancer (GC) and promotes GC cell proliferation through the miR-144-3p/CBX4 axis.
Correction
Biochemistry & Molecular Biology
Wei Zhao, Yameng Cui, Lina Liu, Xiaoqian Qi, Jingwen Liu, Shiqing Ma, Xin Hu, Zheng Zhang, Yue Wang, Hongfa Li, Zuomin Wang, Zihao Liu, Jie Wu
Summary: After the online publication of this article, the authors identified errors in the images used for compiling Fig. 3c, 3g, and Supplementary Fig. 3g.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Qian Zeng, Fangfang Jin, Husun Qian, Hongling Chen, Yange Wang, Dian Zhang, Yu Wei, Tingmei Chen, Bianqin Guo, Chengsen Chai
Summary: This study found that miR-345-3p gene is upregulated in breast cancer tissues and cells, and its overexpression enhances the proliferation and invasion of breast cancer cells. The study also discovered that miR-345-3p promotes AKT phosphorylation by inhibiting protein phosphatase 2 catalytic subunit alpha (PPP2CA), and regulates the PI3K-AKT signaling pathway. Furthermore, inhibiting miR-345-3p can suppress tumor growth and invasiveness in mice.
Article
Biochemistry & Molecular Biology
Junfeng Ying, Guanglan Liu, Xinguo Zhu
Summary: This study investigated the impact of circ_0007385 on colorectal cancer (CRC) cell malignant behaviors and revealed its potential mechanism. Functional experiments confirmed the role of hsa_circ_0007385 in CRC. Further analysis revealed the relationship between hsa_circ_0007385 and miRNAs. A xenograft mouse model demonstrated the influence of hsa_circ_0007385 on CRC growth and metastasis.
BIOCHEMICAL GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Tao Cai, Binyu Peng, Jun Hu, Yan He
Summary: Gastric cancer is a significant health burden worldwide, but the molecular mechanisms underlying its progression are not well understood. This study reveals the role of BBOX1-AS1 in regulating gastric cancer progression through the miR-361-3p/MUC13 axis, providing a potential therapeutic target for the treatment of gastric cancer.
Article
Immunology
Misagh Rajabinejad, Gelayol Asadi, Sedigheh Ranjbar, Fatemeh Rezaei Varmaziar, Mojgan Karimi, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh, Leila Afshar Hezarkhani
Summary: The MALAT1-H19/miR-19b-3p axis may be involved in the development of DN, and these molecules could be useful biomarkers for DN. Dysregulated expression of SEMA4C, PLXNB2, and ATG16L1, targeted by miR-19b-3p and miR-125a-5p, showed that they probably play a role in the development of DN.
IMMUNOLOGY LETTERS
(2022)
Article
Oncology
Hina Mir, Neeraj Kapur, Dominique N. Gales, Praveen K. Sharma, Gabriela Oprea-Ilies, Anita T. Johnson, Rajesh Singh, Shailesh Singh
Summary: Breast cancer (BrCa) is the second leading cause of cancer-related deaths in American women, and its incidence is increasing. This study highlights the importance of the chemokine axis CXCR6/CXCL16 in promoting BrCa and suggests it as a potential therapeutic target for advanced-stage BrCa.
Article
Cardiac & Cardiovascular Systems
Yufu Wu, Qing Mao, Xiulin Liang
Summary: The study found that the expression of miR-490-3p is decreased and that of ATG4B is increased during ischemia reperfusion. Inhibiting miR-490-3p or overexpressing ATG4B can promote autophagy to reduce myocardial IR injury.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yukang Wu, Xudong Guo, Tong Han, Ke Feng, Peng Zhang, Yanxin Xu, Yiwei Yang, Yuchen Xia, Yang Chen, Jiajie Xi, Huangtian Yang, Xiaoping Wan, Jiuhong Kang
Summary: The overexpression of lncRNA-Cmarr promotes the maturation of mouse ESC-CMs and the transplantation of cardiac patch overexpressing Cmarr improves cardiac function in mice after myocardial infarction.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cell Biology
Juan F. Linares, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Anxo Martinez-Ordonez, Miguel Reina-Campos, Hui-Hsuan Kuo, Olivier Elemento, M. Laura Martin, Thekla Cordes, Timothy C. Thompson, Christian M. Metallo, Jorge Moscat, Maria T. Diaz-Meco
Summary: This study reveals that tumor-secreted lactate downregulates p62 by reducing the NAD(+)/NADH ratio, leading to the activation of cancer-associated fibroblasts (CAF). Importantly, restoring p62 levels in CAFs by increasing NAD(+) can inhibit CAF activity.
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Oncology
Jing Hu, Deyu Liao, Zijiu Sun, Wei Ren, Ling Zhao, Yuting Fang, Kai Hu, Huomei Yu, Shiyan Liu, Lan Zhou, Tongchuan He, Yan Zhang
Summary: This study discovered that HPV16 E6 and E7 can affect the development of HPV16-positive cervical cancer by regulating the expression of miR-23b-3p and ICAT genes, which is significant for the treatment of HPV16-associated cervical cancer.
Article
Oncology
Zi-Jian Deng, Jun Lu, Run-Cong Nie, Jia-Ming Fang, Xi-Jie Chen, Jun-Jie Liu, Xian-Zhe Li, Ying-Bo Chen, Chang-Ming Huang, Lei Lian, Jun-Sheng Peng, Shi Chen
Summary: This study aimed to explore the indications for adjuvant chemotherapy in patients with stage II gastric cancer by constructing an individual prediction model. It was found that high-risk patients may benefit from adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Jie Zhou, Run-cong Nie, Yi-xin Yin, Yun Wang, Shu-qiang Yuan, Zi-han Zhao, Xin-ke Zhang, Jin-ling Duan, Ying-bo Chen, Zhi-wei Zhou, Dan Xie, Yuan-fang Li, Mu-yan Cai
Summary: This study investigates the relationship between pyroptosis and the tumor immune microenvironment (TIME) in gastric cancer. It identifies distinct clusters based on pyroptosis and constructs a risk scoring system. The low-pyroptosis risk score is associated with better immune cell fractions, higher MSI status, and increased response to immunotherapy. The study highlights the importance of the interaction between pyroptosis and TIME in gastric cancer, and the potential of the risk scoring system in predicting survival and response to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yuan Fang Li, Yun Wang, Jie Zhou, Yi Cheng Wei, Jun Lin, Yi Xin Yin, Guo Ming Chen, Fei Yang Zhang, Shi Chen, Zhi Wei Zhou, Ying Bo Chen, Run Cong Nie
Summary: This study aimed to assess whether RECIST-based ORR, DCR, and PFS can serve as surrogate endpoints for OS in IO trials of GE carcinoma. The results showed strong correlations between ORR and PFS with OS, while the correlation of DCR with OS was weak. PFS may be an appropriate surrogate for OS in GE carcinoma IO trials, with a minimum threshold effect of HRPFS at 0.73.
WORLD JOURNAL OF ONCOLOGY
(2022)
Editorial Material
Oncology
Run-Cong Nie, Tian-Qi Luo, Guo-Dong Li, Fei-Yang Zhang, Guo-Ming Chen, Jin-Xing Li, Xiao-Jiang Chen, Zhou-Kai Zhao, Kai-Ming Jiang, Yi-Cheng Wei, Ming-Wei Hang, Shi Chen, Ying-Bo Chen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Engineering, Chemical
Junbo Cui, Yingbo Chen, Pengfei Guo, Wenxuan Su, Linzhe Xu, Yuanyuan Zhang
Summary: In order to address the issue of environmental pollution caused by waste reverse osmosis (RO) membranes, we recycled and reused the end-of-life RO membrane as a nanofiltration (NF) membrane through a cleaning-healing-interfacial polymerization (IP) method. The influence of different repair methods on the subsequent IP process and the performance of the NF membrane were discussed. The NF membrane prepared with 2.0 layers of self-assembled healed membranes showed excellent long-term stability, fouling resistance, and high rejection rates for Na2SO4 solutions of different concentrations, indicating its potential as a tight nanofiltration membrane. This work provides an economic and environmentally friendly approach for the future treatment of waste RO membrane modules.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Wenxuan Su, Lei Liu, Yingbo Chen, Junbo Cui, Xinyu Zhao
Summary: In this study, the speed of the interfacial polymerization reaction was controlled by controlling the diffusion rate of the aqueous monomer, thereby affecting the thickness and surface morphology of the polyamide layer. Polyethylene oxide (PEO) was added to increase the viscosity of the aqueous phase and slow down the reaction rate. Choline chloride (CC) was then grafted onto the surface of the polyamide membrane for secondary modification. The addition of 1% PEO resulted in the best performance of the composite membrane, and after CC modification, the rejection rate of (NaSO4)-S-2 was more than 96% with a permeation flux of 125.9 L/(m(2)center dot h center dot MPa). This composite membrane has potential applications in seawater desalination and sewage purification.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Engineering, Chemical
Meng Wang, Yingbo Chen, Wenxuan Su, Ke Zhao, Xianshe Feng
Summary: This study proposed a new method to enhance the treatment performance of chromium-containing wastewater by using sodium alginate (SA) encapsulated nano zero-valent iron particles (nZVI) loaded in the pores of aminated spherical magnesium hydroxide (MH-NH2). The prepared ternary composite showed great stability and dispersibility, and exhibited high efficiency in removing Cr(VI) from the solution under acidic conditions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Linzhe Xu, Yingbo Chen, Wenxuan Su, Junbo Cui, Siyu Wei
Summary: A mixed matrix membrane of amidoximized poly-acrylonitrile with MXene particles was prepared, which exhibited excellent selectivity and high adsorption capacity for U(VI) ions in natural seawater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Geochemistry & Geophysics
Shanbin He, Kun Meng, Ce Wang, Yingbo Chen, Hao Zhao, Haoyuan Wang, Hongyan Yu
Summary: The identification of reservoir fractures is crucial for designing a field development plan and improving the efficiency of hydrocarbon production. However, the lack of understanding of fracture development patterns in tight oil reservoirs in the Triassic Change 6 member of Y well area, Ordos Basin, China has led to issues such as water flooding and water channeling. This study analyzed cores from 20 wells, fractures, and outcrop profiles to identify controlling factors for fracture development and establish a fracture prediction method using conventional logging data. The findings indicate that fractures in this area have high angles, nearly east-west orientations, small spacing, small openings, small down-cutting depths, and a low filling rate. Thin beds and fine sandstones are prone to fracture development, and the modified curve change rate method is effective for fracture prediction in the Triassic Change 6 member tight sandstone reservoirs in the Y well area, Ordos Basin, China.
Article
Oncology
Jiaming Fang, Feiyang Zhang, Jun Lu, Zijian Deng, Xianzhe Li, Xijie Chen, Changming Huang, Yingbo Chen, Lei Lian, Junsheng Peng, Shi Chen
Summary: This study aimed to construct a prognostic model for prognosis prediction and assess the response to adjuvant chemotherapy (ACT) of stage II gastric cancer (GC) patients. Retrospective review of 547 stage II gastric cancer patients who underwent D2 radical gastrectomy was conducted. The nomogram performed well in prognosis prediction and stratified patients into high-risk and low-risk groups.
Article
Construction & Building Technology
Mingchao Li, Yingbo Chen, Mengxi Zhang, Lin Yang, Haojie Lian, Stephane P. A. Bordas, Rui Kong
Summary: This paper introduces a software platform called Hydraulic IsoGeometric Analysis (HIGA), which integrates geometric modeling, isogeometric analysis solution, and post-processing modules to enable engineers to design and analyze hydraulic structures in an integrated and interactive environment.
AUTOMATION IN CONSTRUCTION
(2023)
Article
Engineering, Environmental
Meng Wang, Yingbo Chen, Yuanyuan Zhang, Ke Zhao, Xianshe Feng
Summary: A new composite adsorbent for Cr(VI) removal was developed by immobilizing PEI on the surface of ZVI particles with TA as a stabilizer. The adsorbent showed excellent stability and high selectivity for Cr(VI) removal even after exposure to air for 30 days. The mechanism of Cr(VI) removal with Fe-TA-PEI-10 was based on adsorption and reduction, making it an efficient and long-lasting reactive adsorbent for Cr(VI) removal.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Pengfei Li, Yingbo Chen, Fan Xiao, Ming Cao, Jingyu Pan, Jingfeng Zheng, Hao Li, Ke Zhao, Xianglin Zhang, Yuanyuan Zhang
Summary: This study successfully prepared a flexible bifunctional material UiO-66-NH-SO3H with hydrophilic functionalized metal-organic frameworks, which was used to enhance the proton conductivity of proton exchange membranes (PEMs). By creating acid-base pairing interaction between UiO-66-NH-SO3H and SPEEK, an effective proton conduction channel was constructed, leading to high proton conductivity in the composite PEMs. The UiO-66-NH-SO3H/SPEEK = 40% composite PEMs showed the lowest methanol permeability and the highest proton selectivity.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yujia Feng, Qinghua Zhou, Feifei Mou, Yingbo Chen, Zhijing Xu
Summary: By comparing the blood specimens of 124 asthma patients, 124 chronic obstructive pulmonary disease patients, and 124 asthma-chronic obstructive pulmonary disease overlap syndrome patients, it was found that high mobility group box 1 levels were significantly elevated in the overlap syndrome group. High mobility group box 1 levels were also correlated with inflammation markers and lung function. Therefore, high mobility group box 1 is of clinical significance in the diagnosis and treatment of asthma-chronic obstructive pulmonary disease overlap syndrome.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Textiles
Chuanfeng Wang, Yingbo Chen, Meng Wang, Renhao Guo
Summary: A dual-layer PVDF loose nanofiltration hollow fiber membrane was designed and optimized through an online-coating device, and then cross-linked to improve solvent stability. The cross-linking process improved the stability in polar solvents with a slight decrease in thermal stability and mechanical properties. The prepared membranes showed excellent rejection of Rose bengal in various solvents and great stability for treatment of RB/ethanol solution, indicating their potential for organic solvent nanofiltration applications.
FIBERS AND POLYMERS
(2023)