Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
V. B. Sameer Kumar, K. Anjali
Summary: One of the major reasons for the non-effectiveness of anticancer therapeutics targeting tumour angiogenesis is the complexity of cellular communication in the tumour micro-environment. Recent research has highlighted the importance of signaling events mediated by exosomes in tumor progression and angiogenesis. This review collates information on the role of exosomal cargo, especially exosomal miRNAs, in modulating tumor angiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
America Campos, Shayna Sharma, Andreas Obermair, Carlos Salomon
Summary: The article discusses the association between miRNAs within extracellular vesicles (EVs) and chemotherapy resistance, identifying certain miRNAs in various cancers linked to chemoresistance. Studies suggest that miR-21, miR-222, and miR-155 have roles in response to chemotherapy in different types of tumors.
Article
Pharmacology & Pharmacy
Mengying Niu, Hong Li, Xu Li, Xiaoqian Yan, Aijun Ma, Xudong Pan, Xiaoyan Zhu
Summary: This study identified four promising exosomal miRNAs associated with large-artery atherosclerosis (LAA) stroke, the most common subtype of ischemic stroke, through high-throughput sequencing and qRT-PCR analysis. These miRNAs can serve as diagnostic biomarkers for LAA stroke, showing superior diagnostic efficiency compared to their plasma counterparts.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Ming Yun Yu, Hui Jie Jia, Jing Zhang, Guang He Ran, Yan Liu, Xiu Hong Yang
Summary: Macrophages are immune cells that are highly diverse and flexible, and play a crucial role in fighting against pathogens and tumor cells. They can polarize into M1 phenotype to exert pro-inflammatory effects or M2 phenotype to exert anti-inflammatory effects in response to different stimuli. The balance of macrophage polarization is closely associated with disease progression, and therapeutic approaches targeting macrophage polarization are feasible.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Chaoliang Liao, Huiwen Liu, Xiangjian Luo
Summary: Nasopharyngeal carcinoma is a unique subtype of head and neck cancer endemic to Southern China and Southeast Asia, with most patients diagnosed in advanced stages and having poor prognosis. Exosomal miRNAs play a crucial role in the tumorigenesis, development, and treatment of NPC, serving as valuable biomarkers.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Cell Biology
Qiao Yi Chen, Ting Wen, Peng Wu, Rui Jia, Ronghua Zhang, Jingxia Dang
Summary: Recent research on exosomes in neurobiology and neurogenerative diseases has shown promising potential for diagnostic and therapeutic applications in ALS. Exosomes are believed to be valuable diagnostic biomarkers and mediators of neuronal degeneration in ALS. However, there are limitations in current isolation and detection methodologies for exosomes in ALS research, despite their therapeutic potential.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Saife N. Lone, Ajaz A. Bhat, Nissar A. Wani, Thasni Karedath, Sheema Hashem, Sabah Nisar, Mayank Singh, Puneet Bagga, Bhudev Chandra Das, Davide Bedognetti, Ravinder Reddy, Michael P. Frenneaux, Wael El-Rifai, Mushtaq A. Siddiqi, Mohammad Haris, Muzafar A. Macha
Summary: The immune system plays a crucial role in regulating tumor growth, and cancer often evades immune surveillance. Recent studies have highlighted the importance of non-coding RNAs, specifically microRNAs (miRNAs), in the mechanism of immune evasion by cancer cells. miRNAs regulate the expression of immune-modulating molecules in various immune cells, as well as in tumor cells and the tumor microenvironment. This review explores the relationship between altered expression patterns of miRNAs in tumors, immune modulation, and the functional control of a wide range of immune cells, providing detailed insights into the crosstalk between tumor immune cells and their potential as prognostic markers or therapeutic agents.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wei Qing Lim, Kie Hoon Michelle Luk, Kah Yee Lee, Nasuha Nurul, Sin Jade Loh, Zhen Xiong Yeow, Qi Xuan Wong, Qi Hao Daniel Looi, Pan Pan Chong, Chee Wun How, Sharina Hamzah, Jhi Biau Foo
Summary: Neurodegenerative diseases are a critical issue in the healthcare system, and current drug management is not effective in stopping the progression of these diseases. The use of stem cell small extracellular vesicles (sEVs) as a non-invasive cell-free therapy has been investigated as an alternative to invasive cell therapy. Enriching sEVs with miRNAs may increase their therapeutic efficacy. This article highlights the pathophysiology of neurodegenerative diseases, discusses the role of sEVs' miRNAs as biomarkers and treatments, and emphasizes the applications and delivery of stem cells and their miRNA-enriched sEVs for treating these diseases.
Letter
Biotechnology & Applied Microbiology
Tianci Liao, Mailin Gan, Yanhao Qiu, Yuhang Lei, Qiuyang Chen, Xingyu Wang, Yiting Yang, Lei Chen, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: This study reveals the important role of exosomes and their miRNAs in cobra envenomation. The isolated exosomes from cobra venom were found to contain a large number of co-expressed and abundant miRNAs, including the specific miR-2904. Further experiments showed that the overexpression of CV-exo-miR-2904 induced symptoms similar to cobra envenomation in mice and caused liver damage, indicating its crucial role in cobra envenomation.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minkyoung Sung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun Woo Lee, Hyo-Deog Rim, Byung-Soo Kim, Seunghee Won, Kyungmin Kim, Seoyoung Jang, Min-Soo Seo, Jungmin Woo
Summary: This study analyzed miRNAs in serum-derived neuronal exosomes to investigate potential biomarkers of acute stress, revealing specific miRNAs in nEVs from an acute severe-stress animal model. These miRNAs show differential expression over time, with the most prominent brain damage observed 7 days after foot shock treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yirizhati Aili, Nuersimanguli Maimaitiming, Yusufu Mahemuti, Hu Qin, Yongxin Wang, Zengliang Wang
Summary: Gliomas are central nervous system tumors with poor prognosis, where exosomal miRNA plays a significant role in their occurrence, development, invasion, metastasis, and treatment resistance. Further systematic research on the association of exosomal miRNA in gliomas is needed for innovative diagnosis and treatment approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Megan C. Shepherd, Enkhtuya Radnaa, Ourlad Alzeus Tantengco, Talar Kechichian, Rheanna Urrabaz-Garza, Ananth Kumar Kammala, Samantha Sheller-Miller, Ramkumar Menon
Summary: This study demonstrated that exosomes derived from decidual and myometrial cells grown under oxidative stress and inflammation conditions can increase the release of inflammatory mediators, leading to cell type dependent fetal inflammatory response in fetal membrane cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Agriculture, Dairy & Animal Science
Wenwen Ren, Yongfeng Zhang, Renqing Dingkao, Chun Huang, Xiaoming Ma, Xiaoyun Wu, Yongfu La, Min Chu, Pengjia Bao, Xian Guo, Jie Pei, Ping Yan, Chunnian Liang
Summary: Exosomes are membranous vesicles produced by living cells, carrying various biomolecules such as proteins, miRNA, and mRNA important for cellular activities. This study characterized exosome miRNAs from yak and Jeryak milk and identified differentially expressed miRNAs related to lactation performance. The findings provide insights into improving lactation performance in yaks and Jeryaks.
Correction
Oncology
M. Koti, A. Siu, I. Clement, M. Bidarimath, G. Turashvili, A. Edwards, K. Rahimi, A-M Mes-Masson, J. A. Squire
BRITISH JOURNAL OF CANCER
(2015)
Article
Oncology
M. Koti, A. Siu, I. Clement, M. Bidarimath, G. Turashvili, A. Edwards, K. Rahimi, A-MM Masson, J. A. Squire
BRITISH JOURNAL OF CANCER
(2015)
Article
Developmental Biology
Rayana Leal Luna, Vanessa R. Kay, Matthew T. Raetsep, Kasra Khalaj, Mallikarjun Bidarimath, Nichole Peterson, Peter Carmeliet, Albert Jin, B. Anne Croy
MOLECULAR HUMAN REPRODUCTION
(2016)
Article
Cell Biology
Mallikarjun Bidarimath, Kasra Khalaj, Rami T. Kridli, Jocelyn M. Wessels, Madhuri Koti, Chandrakant Tayade
CELL AND TISSUE RESEARCH
(2016)
Article
Reproductive Biology
Rami T. Kridli, Kasra Khalaj, Mallikarjun Bidarimath, Chandrakant Tayade
Article
Multidisciplinary Sciences
Kasra Khalaj, Soo Hyun Ahn, Mallikarjun Bidarimath, Yasmin Nasirzadeh, Sukhbir S. Singh, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Mallikarjun Bidarimath, Kasra Khalaj, Rami T. Kridli, Frederick W. K. Kan, Madhuri Koti, Chandrakant Tayade
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Ian M. Rose, Mallikarjun Bidarimath, Alex Webster, Andrew K. Godwin, Andrea Flesken-Nikitin, Alexander Yu. Nikitin
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Dah-Jiun Fu, Andrea J. De Micheli, Mallikarjun Bidarimath, Lora H. Ellenson, Benjamin D. Cosgrove, Andrea Flesken-Nikitin, Alexander Yu Nikitin
DISEASE MODELS & MECHANISMS
(2020)
Review
Veterinary Sciences
Mallikarjun Bidarimath, Harshavardhan Lingegowda, Jessica E. Miller, Madhuri Koti, Chandrakant Tayade
Summary: Spontaneous fetal loss is a major challenge faced by the commercial pig industry in North America, and research has provided insights into mechanisms such as uterine capacity, placental efficiency, vasculature deficits, and immune-inflammatory alterations at the maternal-fetal interface. Pigs have a unique epitheliochorial placentation where maternal and fetal layers do not invade, allowing researchers to study adaptation mechanisms at the maternal-fetal interface. Recent studies have shown that extracellular vesicles (EVs), including exosomes, play a role in communication between fetal trophoblasts and maternal cells/tissues, carrying cargo with unique signatures associated with pregnancy pathologies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Alison McCallion, Yasmin Nasirzadeh, Harshavardhan Lingegowda, Jessica E. Miller, Kasra Khalaj, SooHyun Ahn, Stephany P. Monsanto, Mallikarjun Bidarimath, Danielle J. Sisnett, Andrew W. Craig, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: This study found that mast cell numbers significantly increase in endometriotic lesions, and the microenvironment within these lesions promotes the recruitment and differentiation of mast cells. There is cross-talk between mast cells and endocrine and immune factors, which may contribute to the pathophysiology of endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Kasra Khalaj, SooHyun Ahn, Mallikarjun Bidarimath, Yasmin Nasirzadeh, Steven L. Young, Bruce A. Lessey, Sukhbir S. Singh, Madhuri Koti, Chandrakant Tayade
REPRODUCTIVE SCIENCES
(2017)
Meeting Abstract
Obstetrics & Gynecology
Kasra Khalaj, SooHyun Ahn, Mallikarjun Bidarimath, Sony S. Singh, Chandrakant Tayade
REPRODUCTIVE SCIENCES
(2016)
Meeting Abstract
Obstetrics & Gynecology
Mallikarjun Bidarimath, Kasra Khalaj, Rami T. Kridli, Jocelyn Wessels, Madhuri Koti, Chandrakant Tayade
REPRODUCTIVE SCIENCES
(2016)