Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo

Comparison of 2 synthetically generated recombinant prions

(2014) Yi Zhang et al.   Prion

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

(2014) Malin K. Sandberg et al.   Nature Communications

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease

(2013) Zhe Li et al.   ChemMedChem

Therapy in Prion Diseases

(2013) Gianluigi Forloni et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Immunization with Recombinant Prion Protein Leads to Partial Protection in a Murine Model of TSEs through a Novel Mechanism

(2013) Konstantinos Xanthopoulos et al.   PLoS One

Recombinant Prion Protein Refolded with Lipid and RNA Has the Biochemical Hallmarks of a Prion but Lacks In Vivo Infectivity

(2013) Andrew G. Timmes et al.   PLoS One

Elucidating the role of cofactors in mammalian prion propagation

(2013) Surachai Supattapone   Prion

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Transmissible Proteins: Expanding the Prion Heresy

(2012) Claudio Soto   CELL

Selective Amplification of Classical and Atypical Prions Using Modified Protein Misfolding Cyclic Amplification

(2012) Natallia Makarava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of a Prion Strain of Synthetic Origin Requires Multiple Serial Passages

(2012) Natallia Makarava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Protein misfolding cyclic amplification of infectious prions

(2012) Rodrigo Morales et al.   Nature Protocols

Kosmotropic Anions Promote Conversion of Recombinant Prion Protein into a PrPSc-Like Misfolded Form

(2012) Rodrigo Diaz-Espinoza et al.   PLoS One

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

The Role of Cofactors in Prion Propagation and Infectivity

(2012) Jiyan Ma   PLoS Pathogens

Seeding Specificity and Ultrastructural Characteristics of Infectious Recombinant Prions

(2011) Justin R. Piro et al.   BIOCHEMISTRY

Biological Effects and Use of PrPSc- and PrP-Specific Antibodies Generated by Immunization with Purified Full-Length Native Mouse Prions

(2011) B. Petsch et al.   JOURNAL OF VIROLOGY

Infectivity versus toxicity

(2011) Reed B. Wickner   NATURE

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Prion protein at the crossroads of physiology and disease

(2011) Emiliano Biasini et al.   TRENDS IN NEUROSCIENCES

Genesis of Mammalian Prions: From Non-infectious Amyloid Fibrils to a Transmissible Prion Disease

(2011) Natallia Makarava et al.   PLoS Pathogens

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

(2010) R. A. Shikiya et al.   JOURNAL OF VIROLOGY

Estimating prion concentration in fluids and tissues by quantitative PMCA

(2010) Baian Chen et al.   NATURE METHODS

Prion interference with multiple prion isolates

(2010) Charles R. Schutt et al.   Prion

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

(2010) Abhisek Mukherjee et al.   PLoS Pathogens

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Switching in amyloid structure within individual fibrils: Implication for strain adaptation, species barrier and strain classification

(2009) Ilia V. Baskakov   FEBS LETTERS

Distinct Structures of Scrapie Prion Protein (PrPSc)-seededVersusSpontaneous Recombinant Prion Protein Fibrils Revealed by Hydrogen/Deuterium Exchange

(2009) Vytautas Smirnovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype

(2009) Marcelo A. Barria et al.   PLoS Pathogens

Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin

(2008) Sabrina Cronier et al.   BIOCHEMICAL JOURNAL

Crossing the Species Barrier by PrPSc Replication In Vitro Generates Unique Infectious Prions

(2008) Joaquín Castilla et al.   CELL

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

(2008) Soledad Matus et al.   CURRENT MOLECULAR MEDICINE