Article
Chemistry, Multidisciplinary
Chaemin Lim, Duhyeong Hwang, Mostafa Yazdimamaghani, Hannah Marie Atkins, Hyesun Hyun, Yuseon Shin, Jacob D. Ramsey, Patrick D. Raedler, Kevin R. Mott, Charles M. Perou, Marina Sokolsky-Papkov, Alexander V. Kabanov
Summary: The presence of immunosuppressive immune cells in tumors is a barrier to therapeutic immune responses. This study used polymeric micelles to enhance the adaptive T cell immunity against triple-negative breast cancers (TNBCs) by delivering the small molecule drugs paclitaxel (PTX) and CSF1R inhibitor PLX3397. The combination therapy repolarized the immunosuppressive tumor microenvironment, resulting in inhibited primary tumor growth and metastasis.
Article
Pharmacology & Pharmacy
Linxi Zhu, Qingxin Mu, Jesse Yu, James I. Griffin, Xiaolin Xu, Rodney J. Y. Ho
Summary: By incorporating an ICAM-1-binding peptide on a novel drug-combination nanoparticle, researchers successfully improved the binding and localization of gemcitabine and paclitaxel in breast cancer cells. This strategy may provide a potential solution to overcome drug resistance in advanced metastatic breast cancer, and further clinical development is warranted.
Article
Oncology
Hannah C. Timmins, Tiffany Li, Terry Trinh, Matthew C. Kiernan, Michelle Harrison, Frances Boyle, Michael Friedlander, David Goldstein, Susanna B. Park
Summary: The study reveals that weekly paclitaxel treatment can induce neuropathy early on and patients may require closer monitoring. Dose reduction does not necessarily result in better neuropathy outcomes, with individual risk factors also playing a significant role.
Article
Cell Biology
Yudong Song, Luke Bugada, Ruiting Li, Hongxiang Hu, Luchen Zhang, Chengyi Li, Hebao Yuan, Krishani Kumari Rajanayake, Nathan A. Truchan, Fei Wen, Wei Gao, Duxin Sun
Summary: In this study, a nanoparticle called Nano-PI containing immunomodulators was designed to remodel the immunosuppressive microenvironment of breast cancer in lymph nodes and tumors. Combination therapy with Nano-PI and alpha-PD1 achieved long-term tumor remission and eliminated lung metastases in mouse models. The nanoparticle enhanced drug delivery and accumulation in lymph nodes and tumors, and polarized M2 to M1 macrophages, resulting in immune microenvironment remodeling and preventing T cell exhaustion.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hend M. Nawara, Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Summary: Paclitaxel is a commonly used chemotherapeutic agent that disrupts microtubule dynamics, induces mitotic arrest, and cell death. However, cancer resistance to paclitaxel is a major obstacle in clinical applications, and combining it with other drugs may lead to more efficient therapeutic strategies.
Review
Chemistry, Medicinal
Vipin Mohan Dan, Reji Saradha Raveendran, Sabulal Baby
Summary: Breast cancer is the most prevalent cancer in women globally, and Paclitaxel (PTX) is a frontline chemotherapy drug that has led to the exploration of new therapeutic targets in overcoming PTX resistance. Combining synthetic/natural therapeutics with PTX may help to combat resistance.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Haitao Wang, Sen Guo, Seung-Jin Kim, Fangyuan Shao, Joshua Wing Kei Ho, Kuan Un Wong, Zhengqiang Miao, Dapeng Hao, Ming Zhao, Jun Xu, Jianming Zeng, Koon Ho Wong, Lijun Di, Ada Hang-Heng Wong, Xiaoling Xu, Chu-Xia Deng
Summary: Cisplatin at different doses has varying effects on breast cancer growth and metastasis, with higher doses inhibiting both growth and metastasis but causing severe side effects, and lower doses only blocking metastasis. Cisplatin prevents breast cancer metastasis by blocking early EMT steps.
Article
Chemistry, Applied
Dan Gao, Sajid Asghar, Junxiu Ye, Mei Zhang, Rongfeng Hu, Yadong Wang, Lin Huang, Chengjun Yuan, Zhipeng Chen, Yanyu Xiao
Summary: A dual-targeted enzyme-sensitive hyaluronic acid nanogel loaded with paclitaxel was developed for targeted treatment of breast cancer. The nanogel exhibited small particle size and high drug loading capacity, and released the drug rapidly under the catalysis of specific enzymes. In vivo experiments demonstrated that the nanogel showed excellent therapeutic efficacy against breast tumors.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Chaomei Fu, Jinming Zhang, Zhongwei Gu
Summary: This study developed a redox-sensitive nanosystem for delivering paclitaxel and tetramethylpyrazine simultaneously, demonstrating excellent anticancer effects and anti-angiogenic activity in vivo. The amphiphilic drug conjugate self-assembled into stable nanoparticles with high drug loading, and showed improved therapeutic outcomes compared to monotherapy or combination therapy with free drugs.
Article
Chemistry, Multidisciplinary
Dengyuan Hao, Qian Meng, Chaonan Li, Shaojin Lu, Xiujuan Xiang, Qing Pei, Xiabin Jing, Zhigang Xie
Summary: Tuning the content of copper is highly significant for cancer and neurodegenerative disease treatment. A copper-chelating PTX prodrug was synthesized and could form stable nanoparticles in aqueous media. After internalization by tumor cells, the nanoparticles responded to redox-active species and released PTX, resulting in an enhanced therapeutic outcome for breast cancer with minimal systemic toxicity. This work provides insight into combining metabolic regulation and chemotherapy for malignant tumors.
Article
Engineering, Biomedical
Xiaodong Ma, Pengfei Wang, Qiwei Wu, Junnian Zhou, Dongqing Wang, Deependra Yadav, Hongbo Zhang, Yuezhou Zhang
Summary: Self-assembled nanoparticles provide a promising approach for targeted cancer therapy combining chemotherapy and photodynamic therapy, with improved stability and reduced side effects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Reesha Kakkadavath Vayalakkara, Chun-Liang Lo, Hsin-Hung Chen, Ming-Yin Shen, Ying-Chieh Yang, Arjun Sabu, Yu-Feng Huang, Hsin-Cheng Chiu
Summary: A novel nanotheranostic system was developed for the treatment of breast cancer, showing significant therapeutic efficacy through the dual modality treatment of photothermal effect and NO production. The combination therapy exhibited prominent effects in fully inhibiting tumor growth and promising strategy for cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Qiwei Wu, Xiaodong Ma, Wenhui Zhou, Rong Yu, Jessica M. Rosenholm, Weizhong Tian, Lirong Zhang, Dongqing Wang, Hongbo Zhang
Summary: A stable nanoplatform combining chemotherapy with photodynamic therapy has been established for more effective treatment of pancreatic carcinoma. The designed TPG NPs can carry multiple drugs to improve targeting and enhance therapeutic effects against cancer cells.
Article
Virology
Xinyue Deng, Yinan Shen, Ming Yi, Chaomei Zhang, Bin Zhao, Guansheng Zhong, Dixuan WeiyangLou, Dixuan Xue, Qi Leng, Jun Ding, Ronghua Zhao, Weiguo Jia, Chenfang Dong, Zhijun Dai
Summary: New strategies are needed to improve the treatment of breast cancer. VG161, a novel replicable recombinant oncolytic herpes simplex virus, has shown antitumor effects in various cancers. This study demonstrates that combination therapy with VG161 and paclitaxel effectively inhibits breast cancer growth and elicits a robust antitumor immune response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziyao Lu, Gan Xu, Xiaozhen Yang, Shijia Liu, Yang Sun, Li Chen, Qinying Liu, Jianyong Liu
Summary: Researchers have developed a dual-activated prodrug, BTC, which combines photodynamic therapy and chemotherapy for selective treatment of tumors. The prodrug has low toxicity and can be selectively taken up by tumor cells, leading to improved therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Menglin Wang, Yinglei Zhai, Hao Ye, Qingzhi Lv, Bingjun Sun, Cong Luo, Qikun Jiang, Haotian Zhang, Youjun Xu, Yongkui Jing, Leaf Huang, Jin Sun, Zhonggui He
Article
Engineering, Biomedical
Hao Ye, Kaiyuan Wang, Menglin Wang, Rongzheng Liu, Hang Song, Na Li, Qi Lu, Wenjuan Zhang, Yuqian Du, Wenqian Yang, Lu Zhong, Yu Wang, Bohong Yu, Hong Wang, Qiming Kan, Haotian Zhang, Yongjun Wang, Zhonggui He, Jin Sun
Article
Multidisciplinary Sciences
Bingjun Sun, Cong Luo, Xuanbo Zhang, Mengran Guo, Mengchi Sun, Han Yu, Qin Chen, Wenqian Yang, Menglin Wang, Shiyi Zuo, Pengyu Chen, Qiming Kan, Haotian Zhang, Yongjun Wang, Zhonggui He, Jin Sun
NATURE COMMUNICATIONS
(2019)
Article
Engineering, Biomedical
Huan Xu, Mengying Hu, Mengrui Liu, Sai An, Kaiyun Guan, Menglin Wang, Lei Li, Jing Zhang, Jun Li, Leaf Huang
Article
Engineering, Biomedical
Hao Ye, Kaiyuan Wang, Qi Lu, Jian Zhao, Menglin Wang, Qiming Kan, Haotian Zhang, Yongjun Wang, Zhonggui He, Jin Sun
Article
Oncology
Emily B. Harrison, Alessandro Porrello, Brittany M. Bowman, Adam R. Belanger, Gabriella Yacovone, Salma H. Azam, Ian A. Windham, Subrata K. Ghosh, Menglin Wang, Nicholas Mckenzie, Trent A. Waugh, Amanda E. D. Van Swearingen, Stephanie M. Cohen, Devon G. Allen, Tyler J. Goodwin, Teresa Mascenik, James E. Bear, Sarah Cohen, Scott H. Randell, Pierre P. Massion, Michael B. Major, Leaf Huang, Chad V. Pecot
Article
Nanoscience & Nanotechnology
Mengying Hu, Ying Wang, Zhengsheng Liu, Zhuo Yu, Kaiyun Guan, Mengrui Liu, Menglin Wang, Jun Tan, Leaf Huang
Summary: The study reveals the key role of hepatic macrophages in mediating relaxation-induced alleviation of liver fibrosis. By developing lipid nanoparticles that target activated hepatic stellate cells and encapsulate relaxin gene and miR-30a-5p mimic, a synergistic antifibrosis effect is achieved in mouse liver fibrosis models. This approach demonstrates a proof-of-concept for devising antifibrotic strategies through the complementary application of nanotechnology and basic science.
NATURE NANOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xuefei Zhou, Yun Liu, Mengying Hu, Menglin Wang, Xiangrui Liu, Leaf Huang
Summary: The study demonstrates that targeting gene delivery-induced RLN can modulate macrophages to reduce tumor-associated fibrosis and promote infiltration of anti-tumor T cells. In addition, RLN gene delivery synergizes with PD-L1 blockade to enhance the effectiveness of immunotherapy against tumors.
Article
Multidisciplinary Sciences
Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J. Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie
Summary: The study demonstrates that GLRX reverses PSSG by liberating GSH, inhibiting activation of hepatic stellate cells and liver fibrosis. GLRX depletion exacerbates liver fibrosis, while overexpression of GLRX inhibits PSSG and liver fibrosis development.
Article
Chemistry, Multidisciplinary
Yingli Wang, Jiang Yu, Dan Li, Liwen Zhao, Bingjun Sun, Jiamei Wang, Zhenjie Wang, Shuang Zhou, Menglin Wang, Yinxian Yang, Hongzhuo Liu, Haotian Zhang, Qingzhi Lv, Qikun Jiang, Zhonggui He, Yongjun Wang
Summary: The combination of chemotherapy with immune checkpoint blockade therapy holds great promise for the treatment of malignant tumors, but current chemoimmunotherapy faces challenges such as high cost, low response rate, and off-target toxicity. Developing a high-efficient nanosystem that combines chemotherapeutics with small molecule ICB inhibitors could be a promising approach. By constructing a ROS-activated liposome nanoplatform, co-loading ROS-sensitive paclitaxel derivative and small molecule PD-1/PD-L1 inhibitor, this study demonstrated improved pharmacokinetic properties and superior antitumor activity in an orthotopic breast cancer model. The dual-delivery liposome system showed potential for high-efficient chemo-immunotherapy and clinical translation.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Zhuo Yu, Jianfeng Guo, Yun Liu, Menglin Wang, Zhengsheng Liu, Yueqiu Gao, Leaf Huang
Summary: This study found that the characteristics of liver sinusoidal endothelial cells (LSECs) are closely related to the development and prognosis of fibrotic HCC. Simvastatin restores the quiescence of activated hepatic stellate cells (aHSCs) by stimulating LSECs and upregulating the expression of CXCL16 in LSECs. LSEC-targeted delivery of simvastatin not only alleviates LSEC capillarization, but also inhibits tumor progression by recruiting natural killer T (NKT) cells through CXCL16. Conclusion: Simvastatin has an immune-based therapeutic effect on remodeling the immunosuppressive tumor microenvironment in HCC, providing a new strategy for HCC treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hongyan Zhang, Liying Chen, Yue Zhao, Ningchao Luo, Jingbin Shi, Shujun Xu, Lisha Ma, Menglin Wang, Mancang Gu, Chaofeng Mu, Yang Xiong
Summary: Cancer-associated fibroblasts (CAFs) play a significant role in promoting an immunosuppressive microenvironment in triple-negative breast cancer (TNBC), leading to the failure of immunotherapy. This study focuses on using a polymeric nanoparticle called LPPR to target and inhibit CAFs, thus reshaping the tumor microenvironment to enhance the effect of immune checkpoint blockade therapy in TNBC.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Menglin Wang, Benoit Rousseau, Kunyu Qiu, Guannan Huang, Yu Zhang, Hang Su, Christine Le Bihan-Benjamin, Ines Khati, Oliver Artz, Michael B. Foote, Yung-Yi Cheng, Kuo-Hsiung Lee, Michael Z. Miao, Yue Sun, Philippe-Jean Bousquet, Marc Hilmi, Elise Dumas, Anne-Sophie Hamy, Fabien Reyal, Lin Lin, Paul M. Armistead, Wantong Song, Ava Vargason, Janelle C. Arthur, Yun Liu, Jianfeng Guo, Xuefei Zhou, Juliane Nguyen, Yongqun He, Jenny P. -Y. Ting, Aaron C. Anselmo, Leaf Huang
Summary: Research has shown that the tumor microbiota can influence cancer progression. Targeting anaerobic bacteria with pre-resection antibiotics significantly improves disease-free survival in colorectal cancer patients. By designing an antibiotic encapsulated in liposomes, tumor-associated bacteria can be eliminated without disrupting the gut microbiome, leading to enhanced anti-tumoral immunity and potential interventions in microbiome-immunotherapy.
NATURE BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Yun Liu, Karthik Tiruthani, Menglin Wang, Xuefei Zhou, Nasha Qiu, Yang Xiong, Chad V. Pecot, Rihe Liu, Leaf Huang
Summary: Adipocytes in the TME of TNBC can exacerbate tumor progression, with CCL2 identified as a key mediator secreted by TAAs. Utilizing a CCL2 trap, this study successfully ameliorated the immunosuppressive TME and showed enhanced therapeutic efficacy compared to commercial CCL2 antibodies.
NANOSCALE HORIZONS
(2021)
Article
Materials Science, Biomaterials
Qingzhi Lv, Dun Wang, Zimeng Yang, Jincheng Yang, Ruoshi Zhang, Xiaoguang Yang, Menglin Wang, Yongjun Wang
BIOMATERIALS SCIENCE
(2019)