Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats

(2016) Dong-Yuan Cao et al.   Molecular Pain

Neuropathy: A name for their pain

(2016) Michael Eisenstein   NATURE

N-Acetyl-Cysteine, a Drug that Enhances the Endogenous Activation of Group-II Metabotropic Glutamate Receptors, Inhibits Nociceptive Transmission in Humans

(2015) Andrea Truini et al.   Molecular Pain

Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex

(2015) Takaki Kiritoshi et al.   NEUROPHARMACOLOGY

Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model

(2015) J. Mika et al.   NEUROSCIENCE

Group II metabotropic glutamate receptor antagonism prevents the antiallodynic effects of R-isovaline

(2015) K.A. Asseri et al.   NEUROSCIENCE

Epigenetic mechanisms of chronic pain

(2015) Giannina Descalzi et al.   TRENDS IN NEUROSCIENCES

Epigenetic regulation of chronic pain

(2015) Lingli Liang et al.   Epigenomics

Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2015) Sheyu Li et al.   PLoS One

HDAC and HAT Inhibitors Differently Affect Analgesia Mediated by Group II Metabotropic Glutamate Receptors

(2014) Magda Zammataro et al.   Molecular Pain

l-Acetylcarnitine in dysthymic disorder in elderly patients: A double-blind, multicenter, controlled randomized study vs. fluoxetine

(2013) Giuseppe Bersani et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Analgesic Effect of a Single Preoperative Dose of the Antibiotic Ceftriaxone in Humans

(2013) Angela Macaluso et al.   JOURNAL OF PAIN

Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine

(2013) Bruna Cuccurazzu et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: Implications in the development of neuropathic pain

(2013) H. Uchida et al.   NEUROSCIENCE

Synergistic Effects of Celecoxib and Bupropion in a Model of Chronic Inflammation-Related Depression in Mice

(2013) Izaque S. Maciel et al.   PLoS One

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

(2013) C. Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

(2012) Stephanie Brumfield et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors

(2012) Matteo Bernabucci et al.   Molecular Pain

Metabotropic Glutamate Receptors as Targets for Analgesia: Antagonism, Activation, and Allosteric Modulation

(2011) Michael C. Montana et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

mGlu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain and Mediate the Analgesic Activity of Dual mGlu2/mGlu3 Receptor Agonists

(2011) Magda Zammataro et al.   Molecular Pain

Epigenetic suppression of GAD65 expression mediates persistent pain

(2011) Zhi Zhang et al.   NATURE MEDICINE

The beta-lactam antibiotic, ceftriaxone, inhibits the development of opioid-induced hyperalgesia in mice

(2011) Zhijun Chen et al.   NEUROSCIENCE LETTERS

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

(2010) N. Attal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain

(2010) H. Uchida et al.   JOURNAL OF NEUROSCIENCE

Functional Plasticity of Group II Metabotropic Glutamate Receptors in Regulating Spinal Excitatory and Inhibitory Synaptic Input in Neuropathic Pain

(2010) H.-Y. Zhou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of Class II Histone Deacetylases in the Spinal Cord Attenuates Inflammatory Hyperalgesia

(2010) Guang Bai et al.   Molecular Pain

Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion

(2010) Cristiano R. Jesse et al.   PSYCHOPHARMACOLOGY

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

(2010) Santina Chiechio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Thioctic Acid and Acetyl-L-Carnitine in the Treatment of Sciatic Pain Caused by a Herniated Disc

(2009) Antonio Memeo et al.   CLINICAL DRUG INVESTIGATION

Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection

(2009) V Valcour et al.   HIV MEDICINE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury

(2009) H. Uchida et al.   NEUROSCIENCE

Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice

(2008) Yuan Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy

(2008) Jeffery D Evans et al.   ANNALS OF PHARMACOTHERAPY

Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function

(2008) Susan M. Carlton et al.   BRAIN RESEARCH

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS

Group II metabotropic glutamate receptor activation attenuates peripheral sensitization in inflammatory states

(2008) J. Du et al.   NEUROSCIENCE

Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-l-carnitine

(2007) Wen Hua Xiao et al.   PAIN