Article
Multidisciplinary Sciences
Calvin R. K. Blaschke, Elizabeth G. Hill, Anand S. Mehta, Peggi M. Angel, Christine Laronga, Richard R. Drake
Summary: This study explores the application of serum N-glycan profiling in breast cancer screening. Serum N-glycan analysis can help identify differences between breast cancer patients and patients with benign lesions, especially in healthy weight women within the age group recommended for mammograms.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Andrew W. Manigault, Kate R. Kuhlman, Michael R. Irwin, Steve W. Cole, Patricia A. Ganz, Catherine M. Crespi, Julienne E. Bower
Summary: The study found that stress moderates the association between inflammation and depressive symptoms, with higher levels of stress linked to increased vulnerability to inflammation-induced depression. Childhood stress had a smaller impact on the results.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Senay Burcin Alkan, Mehmet Artac, Faruk Aksoy, Mehmet Metin Belviranli, Mehmet Gurbilek, Hilal Akay Cizmecioglu, Neslisah Rakicioglu
Summary: This study evaluates the relationship between dietary and serum advanced glycation end-products (AGEs) with serum inflammatory and oxidative stress biomarkers in breast cancer (BC) patients. The study suggests a limited correlation between dietary and serum AGEs with inflammation and oxidative stress biomarkers in BC patients. Treatment appears to decrease the levels of inflammation and oxidative stress biomarkers, but dietary and serum AGE levels do not correspondingly decline. HER2- subtype is associated with higher dietary and serum AGEs as well as higher inflammatory and oxidative stress biomarkers.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Psychology, Multidisciplinary
Yael Slaghmuylder, Emelien Lauwerier, Peter Pype
Summary: This study examined how breast cancer survivors perceive the addressing of their (chronic) pain complaints during follow-up care and how they cope with the unfolding of their trajectories. The study revealed unmet needs and varied experiences in dealing with pain among survivors. Coping strategies included ignoring the pain, seeking solutions to reduce pain, and accepting pain and its impact. The way survivors cope with pain is influenced by intrapersonal, interpersonal, and societal factors.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin-Yu Li, Chuan Liu, Fang-Hua Liu, Gang Zheng, Hui-Juan Yang, Yi-Fan Wei, Xue Qin, Qian Xiao, Yu-Hong Zhao, Song Gao, Ting-Ting Gong, Qi-Jun Wu
Summary: This study investigated the relationship between diet quality and survival in patients with ovarian cancer using Chinese diet quality scores. The results showed that the Chinese Healthy Eating Index was associated with improved overall survival, while the Dietary Balance Index and Chinese Food Pagoda Score were not related to survival.
Article
Cell Biology
Jiteng Fan, Jichen Sha, Shuwai Chang, Huijuan Zhao, Xiaoyun Niu, Yong Gu, Jianxin Gu, Shifang Ren
Summary: Caloric restriction (CR) has been shown to extend lifespan and improve age-related diseases. This study aimed to explore the molecular basis of CR and its effect on global N-glycans. By conducting comprehensive serum glycome profiling in mice under 30% calorie restriction and ad libitum groups, it was found that most glycans, including galactosylated and high mannose glycans, had consistently lower levels in the CR group. Additionally, O-acetylated sialoglycans showed an upward change, mainly in two biantennary a2,6-linked sialoglycans. Liver transcriptome analysis further revealed decreased transcriptional levels of genes involved in N-glycan biosynthesis and increased acetyl-CoA production. Overall, this study provided insights into the beneficial effect of CR from a glycosylation perspective.
Article
Pharmacology & Pharmacy
Stav Brown, Joseph H. Dayan, Michelle Coriddi, Leslie McGrath, Raghu P. Kataru, Babak J. Mehrara
Summary: This retrospective study analyzed the efficacy of using doxycycline to treat breast cancer-related lymphedema. The results showed no significant improvements in limb volume or L-Dex scores, but patients reported significant improvements in quality of life measures. This suggests that doxycycline may have a role in improving quality of life for patients with breast cancer-related lymphedema, although further larger studies are needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benildo Sousa Cavada, Messias Vital Oliveira, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Francisco William Viana Martins, Cornevile Correia-Neto, Ronald Feitosa Pinheiro, Rodrigo Bainy Leal, Kyria Santiago Nascimento
Summary: Poor lifestyle choices and genetic predisposition contribute to the increase in cancer cases, such as breast cancer. The development of new strategies for early detection and treatment options is needed to improve survival rates. Glycans on cancer cell surfaces serve as efficient tumor cell markers and can be recognized by lectins. Plant lectins have potential applications in diagnosing and treating breast cancer by detecting and sorting glycans in healthy and malignant cells. Furthermore, lectins can be utilized in various ways, such as mapping differentially expressed glycans, histochemistry/cytochemistry analysis, lectin arrays, chromatographic matrices, drug delivery, and biosensing.
Article
Biochemistry & Molecular Biology
Marie Petit, Marie-Laure Walet-Balieu, Damien Schapman, Marie-Laure Golinski, Carole Burel, Marion Barray, Laurent Drouot, Maud Maho-Vaillant, Vivien Hebert, Olivier Boyer, Muriel Bardor, Pascal Joly, Sebastien Calbo
Summary: The pathogenicity of serum IgG in pemphigus patients is correlated with disease activity, and alterations in N-glycan structure can affect the in vitro pathogenicity of autoantibodies. The pathogenic properties of pemphigus IgG do not seem to be related to variations in IgG N-glycans during the course of the disease.
Article
Medicine, General & Internal
Robert Siegel, Ricardo Niklas Werner, Stephan Koswig, Matthew Gaskins, Claus Roedel, Felix Aigner
Summary: The study provides detailed information on the development of the guidelines for the treatment of anal cancer. It recommends chemoradiotherapy as the standard treatment for stages II-III, with a suggestion against biopsy in complete clinical response. For stage IV anal cancer, there are only open recommendations, urging further research in this area.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jiaomei Li, Zhaohong Zheng, Min Liu, Yiping Ren, Yue Ruan, Duo Li
Summary: The study found that breast cancer patients had a significantly lower n-3 index compared to healthy controls, and the n-3 index was inversely associated with breast cancer risk. Serum metabolites showed differences between the two groups, with 16 alpha-hydroxy DHEA 3-sulfate potentially playing a role in connecting n-3 PUFA deficiency and breast disease etiology.
Article
Immunology
Anne Helene Kostner, Anniken Jorlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten
Summary: This study found that the acute phase reactant C-reactive protein (CRP), which can be diagnostically measured by serum levels, is correlated with poor outcomes in different types of cancer. Specifically, high levels of CRP are associated with the pro-inflammatory monomeric isoform of CRP (mCRP) within the tumor microenvironment (TME) in colon cancer patients. These findings shed light on the potential role of CRP in tumor biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Fiorenza De Rose, Bruno Meduri, Maria Carmen De Santis, Antonella Ferro, Lorenza Marino, Riccardo Ray Colciago, Fabiana Gregucci, Valentina Vanoni, Giovanni Apolone, Serena Di Cosimo, Suzette Delaloge, Javier Cortes, Giuseppe Curigliano
Summary: Current follow-up strategies for breast cancer need to be re-evaluated to consider individual differences. New strategies should take into account subtypes, prognosis, and treatments. Advanced prediction models, imaging techniques, and biomarker assessment can help in anticipating diseases. Patient education and involvement of general practitioners are also important in personalized surveillance programs.
CANCER TREATMENT REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Barbara Radovani, Frano Vuckovic, Aldo P. Maggioni, Ele Ferrannini, Gordan Lauc, Ivan Gudelj
Summary: This study investigated the association between N-glycosylation of immunoglobulin G (IgG) and coronary artery disease (CAD). The analysis revealed differences in IgG N-glycome composition between CAD+ and CAD- cases, particularly in women, where sialylated N-glycan structures were negatively associated with CAD.
Review
Nutrition & Dietetics
Siofra E. Maher, Eileen C. O'Brien, Rebecca L. Moore, David F. Byrne, Aisling A. Geraghty, Radka Saldova, Eileen F. Murphy, Douwe Van Sinderen, Paul D. Cotter, Fionnuala M. McAuliffe
Summary: During pregnancy, the maternal gut microbiome and potentially the fetal microbiome undergo changes. Diet has been shown to impact the gut microbiome, but little research has been conducted on diet during pregnancy. This review identified seven studies showing an association between maternal diet and gut microbiome, with high-fat diets being associated with reduced microbial diversity and fiber intake being positively associated with microbial diversity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Immunology
Yusuke Mimura, Yuka Mimura-Kimura, Radka Saldova, Pauline M. Rudd, Roy Jefferis
Summary: Intravenous immunoglobulin (IVIG) modulates immune responses through Fc gamma receptor IIIa blockade and nonfucosylated IgG glycoforms show higher affinity and inhibitory potency in antibody-dependent cellular cytotoxicity (ADCC). This study provides insights into improved therapeutic strategies for autoimmune/inflammatory diseases using glycoengineered IVIG and recombinant Fc.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Sarah Louise Killeen, David F. Byrne, Aisling A. Geraghty, Mark T. Kilbane, Patrick J. Twomey, Malachi J. McKenna, Cara A. Yelverton, Radka Saldova, Douwe Van Sinderen, Paul D. Cotter, Eileen F. Murphy, Fionnuala M. McAuliffe
Summary: In women with obesity, the prevalence of metabolically unhealthy obesity (MUO) was lower using the cardiometabolic disease staging system (CMDS) than the Edmonton obesity staging system (EOSS). C3 and CRP may serve as useful clinical biomarkers for assessing risk and guiding treatment in these women.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Article
Reproductive Biology
Laura Abril-Parreno, Jack Morgan, Anette Krogenaes, Xavier Druart, Paul Cormican, Mary E. Gallagher, Colm Reid, Kieran Meade, Radka Saldova, Sean Fair
Summary: Poor cervical sperm transport in some ewe breeds following cervical artificial insemination using frozen-thawed semen could be due to differences in cervical sialic acid composition and the proportion of neutral and sialylated O-glycans. This study found specific alterations in sialylated mucin composition may be related to impaired cervical sperm transport in certain sheep breeds.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemical Research Methods
Rachel Ronan, Aniket Kshirsagar, Ana Lucia Rebelo, Abbah Sunny, Michelle Kilcoyne, Roisin O' Flaherty, Pauline M. Rudd, Gerhard Schlosser, Radka Saldova, Abhay Pandit, Siobhan S. McMahon
Summary: Traumatic spinal cord injury disrupts tissue integrity and function. This study investigates the role of glycosylation in regeneration and suggests that targeting glycosylation could be a promising strategy for future therapies.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Oncology
Torgeir Mo, Siri Helene Bertelsen Brandal, Alvaro Kohn-Luque, Olav Engebraaten, Vessela N. Kristensen, Thomas Fleischer, Tord Hompland, Therese Seierstad
Summary: Hypoxia is common in solid tumors and is associated with treatment resistance. Identifying hypoxia in solid tumors is important for treatment planning. This study validates the concept of hypoxia in breast cancer and develops a new approach for hypoxia imaging.
Article
Biochemistry & Molecular Biology
Adria Duran, Pedro E. Guerrero, Maria Rosa Ortiz, Dunia Perez Del Campo, Ernesto Castro, Adelaida Garcia-Velasco, Esther Fort, Rafael de Llorens, Radka Saldova, Esther Llop, Rosa Peracaula
Summary: Currently, there is a lack of reliable biomarkers for the diagnosis of pancreatic cancer. Analyzing the glycan determinants on specific glycoproteins offers a more specific approach to develop cancer biomarkers. Mesothelin is a newly expressed glycoprotein in pancreatic cancer. This study investigated the glycosylation of mesothelin and found that core fucosylated mesothelin glycoforms were differently expressed in pancreatic cancer patients compared to control subjects.
Correction
Chemistry, Multidisciplinary
Markus Fusser, Anders Overbye, Abhilash D. Pandya, Yrr Morch, Sven Even Borgos, Wanja Kildal, Sofie Snipstad, Einar Sulheim, Karianne Giller Fleten, Hanne Arenberg Askautrud, Olav Engebraaten, Kjersti Flatmark, Tore Geir Iversen, Kirsten Sandvig, Tore Skotland, Gunhild M. Maelandsmo
JOURNAL OF CONTROLLED RELEASE
(2022)
Letter
Dermatology
Mark Donovan, Rebecca Duke, Lucie Simonetti, Nukhet Cavusoglu, Pauline M. Rudd, Dominique Bernard
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Lisa Svartdal Normann, Mads Haugland Haugen, Vesa Hongisto, Miriam Ragle Aure, Suvi-Katri Leivonen, Vessela N. N. Kristensen, Andliena Tahiri, Olav Engebraaten, Kristine Kleivi Sahlberg, Gunhild Mari Maelandsmo
Article
Multidisciplinary Sciences
Conor Feehily, Ian J. O'Neill, Calum J. Walsh, Rebecca L. Moore, Sarah Louise Killeen, Aisling A. Geraghty, Elaine M. Lawton, David Byrne, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Ida Busch Nielsen, Esther Wortmann, Elizabeth Matthews, Roisin O'Flaherty, Pauline M. Rudd, David Groeger, Fergus Shanahan, Radka Saldova, Fionnuala M. McAuliffe, Douwe Van Sinderen, Paul D. Cotter
Summary: The authors combine isolation and sequencing of bacteria from both mothers and infants to investigate microbial strain transfer, particularly in the genus Bifidobacterium. They reveal that strain transfer occurs in almost 50% of dyads, with factors such as vaginal birth and avoidance of intrapartum antibiotics being important. Dual approaches, combining cultivation and metagenomic sequencing, are necessary for a comprehensive understanding of this transfer process.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Buesra Guenay, Elizabeth Matthews, Jack Morgan, Marianna A. Tryfonidou, Radka Saldova, Abhay Pandit
Summary: This study characterizes the N-glycome of the nucleus pulposus (NP) in young and mature intervertebral discs, and identifies patterns related to aging. Findings show that the levels of outer arm fucosylation and α(2,3)-linked sialylation change during aging. The glycosylation changes related to aging are different from those involved in the degeneration of the NP.
Article
Multidisciplinary Sciences
Zsuzsanna Kovacs, Fiona Reidy, Louise Glover, Fionnuala M. McAuliffe, Henning Stockmann, Mark T. Kilbane, Patrick J. Twomey, Maire Peters, Merli Saare, Pauline M. Rudd, Meeme Utt, Mary Wingfield, Andres Salumets, Radka Saldova
Summary: Endometriosis is a chronic inflammatory gynaecological disease characterized by the growth of endometrial tissue outside the uterine cavity. This study investigates the changes in N-glycans from whole serum glycoproteins associated with endometriosis. The results show significant alterations in glycan profiles in patients with endometriosis compared to control cases, suggesting the potential of using glycosylation as a diagnostic tool for endometriosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Laura Abril-Parreno, Hayden Wilkinson, Anette Krogenaes, Jack Morgan, Mary E. Gallagher, Colm Reid, Xavier Druart, Sean Fair, Radka Saldova
Summary: This study found that the O-glycan composition in cervical mucus is associated with female fertility. Different European ewe breeds had variations in the O-glycan composition of cervical mucus, which correlated with pregnancy rates. The low-fertility Suffolk breed had higher abundance of certain glycans, and the viscosity of cervical mucus was negatively correlated with certain glycans.
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)