Sorafenib analogue SC-60 induces apoptosis through the SHP-1/STAT3 pathway and enhances docetaxel cytotoxicity in triple-negative breast cancer cells

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

(2016) Steffanie L. Furtek et al.   ACS Chemical Biology

Targeting transcription factor STAT3 for cancer prevention and therapy

(2016) Edna Zhi Pei Chai et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutics targeting innate immune/inflammatory responses through the interleukin-6/JAK/STAT signal transduction pathway in patients with cancer

(2016) Campbell S.D. Roxburgh et al.   Translational Research

Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis

(2016) Jung-Chen Su et al.   Scientific Reports

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

(2015) Wei Zhong et al.   JOURNAL OF HEPATOLOGY

RFX1–dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells

(2015) Jung-Chen Su et al.   Oncotarget

SHP-1 is a target of regorafenib in colorectal cancer

(2015) Li-Ching Fan et al.   Oncotarget

Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells

(2014) Chun-Yu Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

STAT3 Mediates Regorafenib-Induced Apoptosis in Hepatocellular Carcinoma

(2014) W.-T. Tai et al.   CLINICAL CANCER RESEARCH

New Strategies for Triple-Negative Breast Cancer--Deciphering the Heterogeneity

(2014) I. A. Mayer et al.   CLINICAL CANCER RESEARCH

The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy

(2014) Fiona Tan et al.   CURRENT DRUG TARGETS

Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity

(2014) Wei-Tien Tai et al.   JOURNAL OF HEPATOLOGY

STAT3 Signaling Is Activated Preferentially in Tumor-Initiating Cells in Claudin-Low Models of Human Breast Cancer

(2014) Wei Wei et al.   STEM CELLS

SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma

(2014) Jung-Chen Su et al.   NEOPLASIA

Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8

(2013) Z. C. Hartman et al.   CANCER RESEARCH

Discovery of novel src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma

(2013) Wei-Tien Tai et al.   HEPATOLOGY

SHP-1-Pyk2-Src Protein Complex and p38 MAPK Pathways Independently Regulate IL-10 Production in Lipopolysaccharide-Stimulated Macrophages

(2013) C. Okenwa et al.   JOURNAL OF IMMUNOLOGY

SHP-1 in Cell-Cycle Regulation

(2012) Pilar Lopez-Ruiz et al.   Anti-Cancer Agents in Medicinal Chemistry

Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3

(2012) Kuen-Feng Chen et al.   BIOCHEMICAL PHARMACOLOGY

A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation

(2012) Kuen-Feng Chen et al.   CANCER LETTERS

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

(2012) Apostolos Kontzias et al.   CURRENT OPINION IN PHARMACOLOGY

Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity

(2012) Kuen-Feng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists

(2012) Jung-Chen Su et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies

(2012) Pasquale Sansone et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells

(2012) Zhinong Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oral administration of penta-O-galloyl- -D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

(2011) H.-J. Lee et al.   CARCINOGENESIS

Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf

(2011) Kuen-Feng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation

(2011) Wei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway

(2011) Xiangyang Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma

(2011) Wei-Tien Tai et al.   JOURNAL OF HEPATOLOGY

Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3

(2011) W.-T. Tai et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells

(2010) Laura D'Anello et al.   Molecular Cancer

Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells

(2009) Nadine A. Binai et al.   INTERNATIONAL JOURNAL OF CANCER