Article
Hematology
Fahumiya Samad, Hongdong Bai, Nagyung Baik, Patrick Haider, Yuqing Zhang, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Johann Wojta, Quyen Bui, Sagarika Chakrabarty, Jing Wang, Robert J. Parmer, Lindsey A. Miles
Summary: Plg-R-KT, a transmembrane plasminogen receptor, plays a vital role in adipose function and metabolic homeostasis. Lack of Plg-R-KT in mice leads to metabolic defects including increased weight gain, hepatic steatosis, and insulin resistance when fed a high fat diet. Plg-R-KT also regulates adipogenic molecules and is crucial for maintaining metabolic balance.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Darcy Kahn, Emily Macias, Simona Zarini, Amanda Garfield, Karin Zemski Berry, Paul MacLean, Robert E. Gerszten, Andrew Libby, Claudia Solt, Jonathan Schoen, Bryan C. Bergman
Summary: Research has found that the secretions of adipose tissue vary based on anatomical location and affect insulin responsiveness through paracrine and endocrine signaling. Visceral adipose tissue secretes more cytokines and adipokines than subcutaneous adipose tissue, leading to a negative impact on insulin action in the liver and muscles.
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Review
Endocrinology & Metabolism
RuiYan Mei, WeiWei Qin, YanHua Zheng, Zhuo Wan, Li Liu
Summary: Exosomes secreted by adipose tissue play a crucial role in metabolic disorders, regulating specific mechanisms related to obesity, adipose inflammation, and diabetes. Adipose tissue is a major source of circulating exosomal miRNAs, which not only alter the state of patients with metabolic diseases but also affect the communication between metabolic organs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ruiqiu Zhao, Yang Ji, Xin Chen, Qiuhui Hu, Liyan Zhao
Summary: This study demonstrated that dietary supplementation of FVP and FMT could attenuate obesity, hyperlipidemia, and insulin resistance in mice fed with a high-fat diet. These effects may be mediated through different mechanisms involving lipid metabolism and regulation of gut microbiota.
Review
Immunology
Weizheng Liang, Yanxu Qi, Hongyang Yi, Chenyu Mao, Qingxue Meng, Hao Wang, Chunfu Zheng
Summary: Macrophages, a population of immune cells, play a vital role in antigen presentation and inflammatory response. Their plasticity and heterogeneity allow them to polarize into different phenotypes under different conditions. Adipose tissue macrophages (ATMs) have been found to be closely related to metabolic diseases such as obesity and diabetes. This article summarizes the factors affecting the polarization of ATMs and explores their potential as targets for immunotherapy in preventing and treating metabolic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Michael P. Franczyk, Nathan Qi, Kelly L. Stromsdorfer, Chengcheng Li, Shintaro Yamaguchi, Hiroshi Itoh, Mihoko Yoshino, Yo Sasaki, Rita T. Brookheart, Brian N. Finck, Brian J. DeBosch, Samuel Klein, Jun Yoshino
Summary: The study showed that NAD(+) and NAMPT have a crucial role in regulating metabolic flexibility, with the loss of NAMPT leading to increased inflammation, decreased insulin sensitivity, and impaired glucose oxidation. This highlights the importance of NAD(+) biosynthesis in adipose tissue in maintaining metabolic health.
Article
Endocrinology & Metabolism
Rens L. J. van Meijel, Max A. A. Vogel, Johan W. E. Jocken, Lars M. M. Vliex, Joey S. J. Smeets, Nicole Hoebers, Joris Hoeks, Yvonne Essers, Paul F. M. Schoffelen, Henrike Sell, Sander Kersten, Kasper M. A. Rouschop, Ellen E. Blaak, Gijs H. Goossens
Summary: Recent studies show that mild intermittent hypoxia exposure can decrease tissue oxygen partial pressure and promote metabolic improvements in overweight/obese men, without significant effects on tissue-specific insulin sensitivity.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Hawley E. Kunz, Corey R. Hart, Kevin J. Gries, Mojtaba Parvizi, Marcello Laurenti, Chiara Dalla Man, Natalie Moore, Xiaoyan Zhang, Zachary Ryan, Eric C. Polley, Michael D. Jensen, Adrian Vella, Ian R. Lanza
Summary: Obesity is associated with systemic and tissue-specific inflammation, reduced insulin sensitivity, and decreased skeletal muscle oxidative capacity. Adipose tissue inflammation is linked to systemic and peripheral metabolic dysregulation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Marina Chaves de Oliveira, Ana Leticia Malheiros Silveira, Amanda Carla Clemente de Oliveira, Jaqueline Pereira Lana, Katia Anunciacao Costa, Erica Leandro Marciano Vieira, Vanessa Pinho, Mauro Martins Teixeira, Fatiha Merabtene, Genevieve Marcelin, Karine Clement, Adaliene Versiani Matos Ferreira
Summary: This study evaluated the participation of eosinophils in metabolic and adipose tissue homeostasis in mice and humans, showing that eosinophils play a role in controlling systemic and adipose tissue metabolic homeostasis by modulating glucose metabolism, inflammation, and visceral fat expansion. These findings provide important insights into the pathogenesis of obesity and metabolic-related diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Gastroenterology & Hepatology
Henrique Souza-Tavares, Carolline Santos Miranda, Isabela Macedo Lopes Vasques-Monteiro, Cristian Sandoval, Daiana Araujo Santana-Oliveira, Flavia Maria Silva-Veiga, Aline Fernandes-da-Silva, Vanessa Souza-Mello
Summary: The intersection of obesity and COVID-19 has become a global concern. Obesity rates have tripled since 1975, leading to significant health costs. Adipose tissue plays a crucial role in obesity-related impairments, leading to insulin resistance and inflammation. Obesity affects the pancreas, increasing the risk of type 2 diabetes, and the liver, leading to hepatic steatosis. Peroxisome proliferator-activated receptors (PPARs) activation shows potential in managing these metabolic diseases by alleviating insulin resistance and promoting fat oxidation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Umesh K. Goand, Saurabh Verma, Inklisan Patel, Saima Tasneem, Richa Garg, Jiaur R. Gayen
Summary: This study aimed to investigate the immunometabolic effect of PST inhibitor (PSTi8) against PST. The results showed that PSTi8 inhibited the expression of lipolytic genes and proteins in 3T3-L1 adipocytes, improved insulin sensitivity and lipid metabolism. Moreover, PSTi8 promoted macrophage polarization, reduced inflammation, and improved energy expenditure. Therefore, PSTi8 may be a potential therapeutic approach for obesity and insulin resistance.
Article
Nutrition & Dietetics
Caitlyn Nguyen-Ngo, Anthony V. Perkins, Martha Lappas
Summary: Gestational diabetes mellitus (GDM) and maternal obesity have long-term detrimental impacts on the health of both mother and offspring. Increased inflammation and oxidative stress play key roles in the pathophysiology of these metabolic conditions. This study found that selenium supplementation may prevent inflammation and oxidative stress associated with GDM and maternal obesity.
Article
Cell Biology
Penghua Fang, Ran Ge, Yuqing She, Juan Zhao, Jing Yan, Xizhong Yu, Yu Jin, Wenbin Shang, Zhenwen Zhang
Summary: Obesity is associated with insulin resistance and T2DM, while physical exercise can improve this condition by increasing the expression of spexin in adipose tissue. Combining spexin with exercise training is an effective therapeutic strategy for age-associated diseases.
AGEING RESEARCH REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Clothilde Philouze, Jean-Charles Martin, Catherine Riva, Alexandra Marziou, Catherine Defoort, Charlene Couturier, Thierry Berton, Julien Astier, Bernard Jover, Nathalie Gayrard, Cyril Reboul, Sandrine Gayrard, Jean-Francois Landrier, Philippe Obert
Summary: Vitamin D-3 supplementation did not affect glucose homeostasis, but improved cardiac remodeling and regional myocardial function, reducing levels of ceramides and diacylglycerol in the myocardium. This study demonstrated the potential benefits of vitamin D in diabetic cardiac disease.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Endocrinology & Metabolism
Imene Bennour, Nicole Haroun, Flavie Sicard, Lourdes Mounien, Jean-Francois Landrier
Summary: Several studies provide strong evidence for the active role of vitamin D in physiological processes of adipocyte and adipose tissue in adulthood. It affects adipocyte and adipose tissue biology parameters like adipogenesis, energy metabolism, and inflammation. Interestingly, recent data suggest that maternal vitamin D deficiency may also impact metabolic programming of adipocytes and adipose tissue in offspring.
Review
Nutrition & Dietetics
Imene Bennour, Nicole Haroun, Flavie Sicard, Lourdes Mounien, Jean-Francois Landrier
Summary: Observational studies show an inverse relationship between vitamin D concentration and obesity, but interventional and genetic studies have not provided clear conclusions. Evidence suggests that vitamin D supplementation may prevent obesity, and maternal vitamin D deficiency could impact the metabolic trajectory of offspring.
Article
Nutrition & Dietetics
Christopher Morrissey, Marie-Josephe Amiot, Aurelie Goncalves, Cecile Raverdy, Delphine Masson, Catherine Tardivel, Sandrine Gayrard, Myriam Carrere, Jean-Francois Landrier, Agnes Vinet, Antonia Perez-Martin
Summary: This study assessed the effects of vitamin D supplementation on arterial stiffness in obese adolescents. The researchers found that a high proportion of obese adolescents had vitamin D deficiency and supplementation improved carotid intima-media thickness (IMT) and reduced the risk of arterial stiffness.
Review
Nutrition & Dietetics
Iskandar Azmy Harahap, Jean-Francois Landrier, Joanna Suliburska
Summary: Obesity is associated with vitamin D deficiency and low calcium status. Dietary supplementation of vitamin D and calcium has been extensively studied in animal experiments and human studies, but the physiological mechanisms underlying their effects on obesity and metabolic diseases remain unclear. The regulation of insulin, lipids, hormones, cells, and inflammation by the vitamin D-calcium axis plays a role in obesity and its comorbidities. However, the impact of simultaneous vitamin D and calcium supplementation on weight loss and fat reduction is inconsistent.
Article
Endocrinology & Metabolism
Laurianne Bonnet, Ida Alexandersson, Ritesh K. K. Baboota, Tobias Kroon, Jan Oscarsson, Ulf Smith, Jeremie Boucher
Summary: Cellular senescence plays a causal role in the development of non-alcoholic steatohepatitis (NASH) by modulating glucose and lipid metabolism, favoring hepatic steatosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Torsten Bohn, Angel R. de Lera, Jean-Francois Landrier, Harald Carlsen, Daniel Merk, Tilman Todt, Jenny Renaut, Ralph Ruehl
Summary: Carotenoids are abundant lipophilic plant metabolites that have potential health benefits for humans, including reduced mortality. They can impact oxidative stress and inflammation through interactions with transcription factors. The article describes both old and new metabolic pathways of carotenoids and their bioactive derivatives, as well as the techniques and tools needed to comprehensively study this topic.
Article
Biochemistry & Molecular Biology
Esma Karkeni, Thomas Payet, Julien Astier, Flavie Sicard, Lourdes Mounien, Jean-Francois Landrier
Summary: Inflammatory markers induced during obesity are linked to comorbidities and can be reduced by active forms of vitamin A and vitamin D. This study revealed that ATRA has anti-inflammatory effects on miRNA expression and showed that ATRA and 1,25(OH)(2)D regulate genes and miRNA that converge to the NF-κB signalling pathway. This bioinformatic approach confirms the interest and importance of studying the regulation of the NF-κB signalling pathway.
Article
Biochemistry & Molecular Biology
Jean -Charles Martin, Claire Bal-dit-Sollier, Jean-Marie Bard, Denis Lairon, Michel Bonneau, Chantal Kang, Murielle Cazaubiel, Corinne Marmonier, Pascale Leruyet, Constance Boyer, Hassan Nazih, Catherine Tardivel, Catherine Defoort, Marion Pradeau, Imene Bousahba, Habib Hammou, Ljubica Svilar, Ludovic Drouet
Summary: The health effects of dairy fats are difficult to evaluate due to the challenges in assessing intake and the heterogeneity of their compositions. This study found that dairy fat intake can reprogram metabolism and have varying effects depending on the quality of the fats. Furthermore, there were shared biological responses to dairy fat consumption in both animals and humans.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Clement Buisson, Lourdes Mounien, Flavie Sicard, Jean-Francois Landrier, Victoria Tishkova, Pierre Sabouroux
Summary: Hepatic steatosis, caused by type 2 diabetes or obesity, is a major origin of chronic liver disease. This study focuses on using a non-invasive technique based on microwave propagation to monitor hepatic tissue pathologies. By measuring the dielectric permittivity, the difference between healthy and fatty liver tissues was observed in a frequency range of 100 MHz to 2 GHz. These results suggest that dielectric permittivity can be a sensitive tool for distinguishing between healthy and fatty hepatic tissue.
Article
Food Science & Technology
Thomas Payet, Marie Valmori, Julien Astier, Ljubica Svilar, Flavie Sicard, Catherine Tardivel, Rania Ghossoub, Jean-Charles Martin, Jean-Francois Landrier, Lourdes Mounien
Summary: This study evaluates the lipid composition of adipocyte-derived extracellular vesicles (AdEVs) treated with vitamin D (VD) and pro-inflammatory factor tumor necrosis factor alpha (TNF alpha). The study highlights four lipid species (glycerolipids, phospholipids, lysophospholipids, and sphingolipids) with differential content in small and large EVs. VD alone modulates EV lipid species involved in membrane fluidity and budding of the membrane. The lipid profiles of EVs treated with VD under inflammatory conditions are different from the control group, particularly in large EVs. In conclusion, VD is associated with specific lipidomic signature of small and large EVs, supporting the anti-inflammatory effect of VD.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lea Sani, Nicolas Cardinault, Julien Astier, Patrice Darmon, Jean Francois Landrier
Summary: This study aimed to evaluate the effect of supplementation with standardized poplar propolis extract powder (PPEP) on insulin homeostasis in non-diabetic insulin-resistant volunteers with obesity. The results showed that PPEP supplementation improved insulin sensitivity by reducing the number of insulin-resistant subjects and decreasing the insulin sensitivity Matsuda index (ISI-M).
Review
Biochemistry & Molecular Biology
Lidia Saidi, Habib Hammou, Flavie Sicard, Jean-Francois Landrier, Lourdes Mounien
Summary: Numerous observational studies have shown that vitamin D insufficiency and deficiency are widespread in various populations, including pregnant women. Vitamin D plays a crucial role in brain differentiation, proliferation, neurotrophic and neuroprotective actions, and modulation of neurotransmission and synaptic plasticity. Recent animal and epidemiological studies have demonstrated that maternal vitamin D deficiency is associated with several neurobiological disorders such as autism, schizophrenia, depression, multiple sclerosis, and developmental defects. This review aims to summarize the current understanding of the impact of maternal vitamin D deficiency on brain functions and development.
Article
Food Science & Technology
Nicole Haroun, Imene Bennour, Eva Seipelt, Julien Astier, Lea Sani, Catherine Tardivel, Ljubica Svilar, Jean-Charles Martin, Lourdes Mounien, Jean Francois Landrier
Summary: This study aims to assess the effects of maternal vitamin D deficiency on hepatic lipid accumulation in adult offspring fed a normal or obesogenic diet.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Bluher, Ulf Smith
Summary: Hepatic cell senescence is a key factor in human NAFLD/NASH. BMP4 and Gremlin 1 are identified as novel therapeutic targets.
