Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity

Structural characterization of a novel derivative of myricetin from Mimosa pudica as an anti-proliferative agent for the treatment of cancer

(2016) Joby Jose et al.   BIOMEDICINE & PHARMACOTHERAPY

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

(2016) O Jun Kwon et al.   Evidence-based Complementary and Alternative Medicine

Inhibitory Kinetics and Mechanism of Flavonoids Extracted from Cotinus coggygria Scop. Against Glioblastoma Cancer

(2016) Gang Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors

(2015) Eunah Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Emerging approaches for histone deacetylase inhibitor drug discovery

(2015) Clemens Zwergel et al.   Expert Opinion on Drug Discovery

The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review

(2015) F. Vahid et al.   GENE

Non-sirtuin histone deacetylases in the control of cardiac aging

(2015) Bradley S. Ferguson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling

(2015) Atsuko Nakayama et al.   PLoS One

Epigenetic activities of flavonoids in the prevention and treatment of cancer

(2015) Christian Busch et al.   Clinical Epigenetics

Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p

(2015) Chen Bian et al.   PLoS One

Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models

(2013) Meixia Huo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dynamic regulation of transcriptional states by chromatin and transcription factors

(2013) Ty C. Voss et al.   NATURE REVIEWS GENETICS

Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases

(2012) Alexander Berger et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension

(2011) Douglas D. Lemon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study

(2011) Mitali Pandey et al.   MOLECULAR CARCINOGENESIS

Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders

(2010) Katarzyna Szarc vel Szic et al.   BIOCHEMICAL PHARMACOLOGY

Flavonoids Influence Epigenetic-Modifying Enzyme Activity: Structure-Function Relationships and the Therapeutic Potential for Cancer

(2010) E.R. Gilbert et al.   CURRENT MEDICINAL CHEMISTRY

Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heart

(2010) Timothy A. McKinsey   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

(2009) Pierre Tessier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

(2008) M. Fournel et al.   MOLECULAR CANCER THERAPEUTICS