Article
Health Care Sciences & Services
Zhirong Wan, Xiaolei Liu, Hui Yang, Fang Li, Lingling Yu, Lei Li, Yulin Wang, Hao Jiang, Junjie Zou, Jichen Du
Summary: This study showed that Health Qigong exercises can significantly improve physical functions in patients with Parkinson's disease, especially in terms of balance ability, gait, and joint range of motion. It can reduce activity risk factors and improve the quality of life for these patients.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Neurosciences
Edgar Pena, Tareq M. Mohammad, Fedaa Almohammed, Tahani AlOtaibi, Shahpar Nahrir, Sheraz Khan, Vahe Poghosyan, Matthew D. Johnson, Jawad A. Bajwa
Summary: Clinical responses to dopamine replacement therapy for individuals with Parkinson's disease (PD) are unpredictable, but changes in MDS-UPDRS motor factor scores and motor cortical magnetoencephalography (MEG) may provide clues for predicting clinical differences. Subject-specific machine learning approaches based on neuroimaging data offer tools to improve prediction of therapeutic outcomes for PD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Hiromi Sano, Atsushi Nambu
Summary: ZNS is an anticonvulsant drug that has beneficial effects on Parkinson's disease and its side effect, L-DOPA-induced dyskinesia, but can also have adverse effects.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Xiying Li, Chuanfen Lv, Xiaolei Liu, Xia Qin
Summary: This study examined the effects of Health Qigong exercise on lower limb motor function in patients with Parkinson's disease (PD). The results showed that Health Qigong exercise improved stride length, gait velocity, and joint range of motion in patients with PD, and reduced motor difficulties and improved their quality of life.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Marc Morissette, Melanie Bourque, Marie-Eve Tremblay, Therese Di Paolo
Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Gunasingh J. Masilamoni, Christopher G. Sinon, Brik A. Kochoian, Arun Singh, Andrew J. McRiner, Liza Leventhal, Stella M. Papa
Summary: This study assessed the effects of a selective PDE9 inhibitor (PDE9i) in a primate model of Parkinson's disease (PD). The results showed that PDE9i enhanced the antiparkinsonian effects of L-DOPA and prolonged its duration of action. This suggests that striatal PDE9 inhibition may be a strategy to improve motor responses to L-DOPA in PD.
Article
Pharmacology & Pharmacy
Cynthia Kwan, Stephen G. Nuara, Jim C. Gourdon, Philippe Huot
Summary: Parkinson's disease psychosis is a complex condition affecting over half of patients and is influenced by multiple factors including dopamine replacement therapy and disease state. Studying novel stereotypical behaviors in MPTP-lesioned marmosets may provide valuable insights for interventions targeting PD psychosis symptoms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Junechul Kim, Sukho Lee
Summary: Appropriate exercise during pregnancy combined with probiotic ingestion can improve offspring mice's motor function and decrease levels of inflammatory cytokines in the brain.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Sathiya Sekar, Yanbo Zhang, Hajar Miranzadeh Mahabadi, Benson Buettner, Changiz Taghibiglou
Summary: Recent studies have shown that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive and motor functions in patients with Parkinson's Disease (PD). A new non-invasive rTMS technique, called gamma rhythm low-field magnetic stimulation (LFMS), generates diffused and low-intensity magnetic stimulation to deep cortical and subcortical areas. In this study, LFMS treatment in an experimental mouse model showed improved motor functions and neuronal survival in MPTP-treated mice, suggesting a potential therapeutic effect of LFMS in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Yuichi Uesugi, Koutatsu Maruyama, Isao Saito, Kiyohide Tomooka, Yasunori Takata, Ryoichi Kawamura, Haruhiko Osawa, Takeshi Tanigawa, Yoshihiko Naito
Summary: In this study, it was found that for men, the impact of work and household chores on TUG performance was mainly concentrated in the 30-64 age group, while men over 65 were mainly associated with skeletal muscle mass. For women, regardless of age, TUG performance was related to height and amount of exercise.
Article
Neurosciences
Andrea Guerra, Valentina D'Onofrio, Francesco Asci, Florinda Ferreri, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: L-dopa variably influences the effects of iTBS-gamma-tACS on M1 in PD patients. However, the combination of iTBS-gamma-tACS therapy improved M1 plasticity and enhanced GABA-A-ergic transmission in PD patients regardless of dopaminergic state.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Zhihua Liu, Aijuan Yan, Jiahao Zhao, Shuyuan Yang, Lu Song, Zhenguo Liu
Summary: The study revealed the important role of p75NTR in patients with Parkinson's disease and suggested it as a new target for managing L-dopa-induced dyskinesia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biology
Abhinav Sharma, Diego Vidaurre, Jan Vesper, Alfons Schnitzler, Esther Florin
Summary: Dopaminergic medication in PD patients affects oscillatory whole-brain networks, leading to coherence within the medial and orbitofrontal cortex in the delta/theta frequency range, and a switch in beta band activity from an STN-mediated motor network to a frontoparietal-mediated one.
Review
Neurosciences
Marianne Tiihonen, Britta U. Westner, Markus Butz, Sarang S. Dalal
Summary: This review found that cycling is particularly beneficial for the motor performance of Parkinson's disease patients, especially in improving crucial features of gait. In terms of intervention effects, motor outcomes benefited significantly more than cognitive outcomes. Additionally, cycling also improves balance, walking speed and capacity, as well as overall quality of life for PD patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Letter
Clinical Neurology
Jules M. Janssen Daalen, Jessica Hubbers, Mirmohsen Sharifi Bonab, Soania Mathur, Dick H. J. Thijssen, Bastiaan R. Bloem, Marjan J. Meinders
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Bastiaan R. Bloem, Erik Post, Deborah A. Hall
Summary: The Rune Labs Kinematics System, a smartwatch-based monitoring system, has been cleared by the FDA to remotely track motor impairments in Parkinson's disease. While this new digital approach shows promise, further validation studies are needed to determine its clinical significance and use in research.
ANNALS OF NEUROLOGY
(2023)
Review
Geriatrics & Gerontology
Lily Man Lee Chan, Oliver Yongyang Yan, Jay Jung Jae Lee, Wendy Wing Tak Lam, Chia-Chin Lin, Man Auyeung, Bastiaan R. Bloem, Jojo Yan Yan Kwok
Summary: Palliative care is associated with lower symptom burden and higher caregiver and patient satisfaction in patients with progressive neurologic diseases. However, the associations are not significant after excluding studies with high risk of bias. The effects of palliative care on caregiver burden and patient quality of life are inconclusive.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Irene Gottgens, Linda Modderkolk, Corine Jansen, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the salience of gender-related aspects in the illness experiences and care provision preferences of people with Parkinson's disease (PD). Most participants did not consider gender-related aspects salient towards their illness experiences, but some described stereotypical views related to visibility of PD, emotional experiences, help seeking, role patterns, and physical appearance. While most participants did not express specific gender-related preferences for their healthcare providers, those that did preferred women as healthcare providers, citing attributed feminine traits relevant in physical examinations of people with PD.
SOCIAL SCIENCE & MEDICINE
(2023)
Review
Clinical Neurology
Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
Summary: There is increasing evidence supporting the positive effects of community-based exercise for individuals with Parkinson's disease. However, the studies on this topic vary greatly in terms of exercise types, study designs, and outcome measures. While this review acknowledges the feasibility and potential benefits of community-based exercise, it also emphasizes the need for improvement in the overall quality of these studies.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jenica Z. Pastor, Gregoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. De Vries, Marie-Laure Welter
Summary: This study aimed to evaluate the efficacy of a home-based training system using a tailored exergame for patients with Parkinson's disease (PD) to improve gait and balance disorders. The results showed that home-based training using a tailored exergame can be performed safely by PD patients and could potentially improve gait and balance disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Jules M. Janssen Daalen, Thomas H. Oosterhof, Bastiaan R. Bloem, Sirwan K. L. Darweesh
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Tessa F. Peerbolte, Rozanne J. A. van Diggelen, Marjan J. Meinders, Bastiaan R. Bloem, Sanne W. van den Berg
PRACTICAL NEUROLOGY
(2023)
Article
Medicine, General & Internal
Irene Goettgens, Linda Modderkolk, Paula Vermue, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the impact of gender norms and stereotypes on illness experiences of people with Parkinson's disease (PD) and provides recommendations for gender-sensitive PD care. The findings suggest that gendered stereotypes affect both the perception of the disease and the social environment of male and female patients. The study emphasizes the importance of considering the influence of gender roles and norms on coping strategies and access to care for individuals with diverse gender identities.