Article
Engineering, Industrial
T. D. Hedberg, M. E. Sharp, T. M. M. Maw, M. M. Helu, M. M. Rahman, S. Jadhav, J. J. Whicker, A. Barnard Feeney
Summary: The industry seeks a digital thread of information to align different viewpoints such as as-designed, as-planned, as-executed, and as-inspected. A research team conducted an experiment to test the ability of selected open data standards to integrate the lifecycle stages of engineering design, manufacturing, and quality assurance, identifying value for industry even though not all required information could be fully linked.
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Rodolphe Poupardin, Martin Wolf, Dirk Strunk
Summary: Research shows a significant improvement in EV characterization in recent years, with papers using more methods and markers being more frequently cited. Papers citing MISEV criteria tend to use a higher number of characterization methods, indicating a positive impact of the guidelines on EV research quality.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Electrical & Electronic
Federico Longoni, Anders Hagglund, Francesco Ripamonti, Paolo L. M. Pennacchi
Summary: The powertrain of a car plays a crucial role in the comfort offered by the vehicle due to vibrations. This paper focuses on identifying quantities that correlate with the vibration performance of powertrain setups and proposes a method to test the specificity of requirements.
Article
Biochemistry & Molecular Biology
James F. Pelletier, Lijie Sun, Kim S. Wise, Nacyra Assad-Garcia, Bogumil J. Karas, Thomas J. Deerinck, Mark H. Ellisman, Andreas Mershin, Neil Gershenfeld, Ray-Yuan Chuang, John Glass, Elizabeth A. Strychalski
Summary: Research has shown that in genomically minimal cells, cell division and morphology are controlled by multiple genes, requiring the action of a series of genes to restore a phenotype similar to that of the original cell.
Article
Engineering, Biomedical
Elizabeth K. Murray, Carine X. You, George C. Verghese, Baruch S. Krauss, Thomas Heldt
Summary: This study developed low-order mechanistic models that quantitatively account for and can be identified from the CO$_{2}$ concentration in exhaled breath. The models fit closely with the measured capnogram and provide subject-specific parameter estimates. Additionally, the models allow estimation of the entire exhaled airflow waveform using Tcap alone. This suggests the potential for new Tcap-based tests to distinguish between COPD and CHF. Overall, the models have implications for cardiorespiratory care.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Microbiology
Norma Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Summary: Oropharyngeal candidiasis (OPC) is a common infection that can range from mild to severe, depending on the patient. The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces involves six key factors, some of which play roles in OPC infectivity in a mouse model. The relationship between fungal burden, hyphae morphogenesis, and infectivity is of significant research interest.
Article
Microbiology
Norma V. Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Summary: Oropharyngeal candidiasis (OPC) is a common infection that can cause mild or severe disease depending on the patient. The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces is also involved in OPC, but the network characteristics and functional connections during infection are distinct from those observed in vitro.
Article
Microbiology
Philip S. Stewart, Kerry S. Williamson, Laura Boegli, Timothy Hamerly, Ben White, Liam Scott, Xiao Hu, Brendan M. Mumey, Michael J. Franklin, Brian Bothner, Francisco G. Vital-Lopez, Anders Wallqvist, Garth A. James
Summary: No universal genetic or biochemical basis for antibiotic tolerance in biofilms was found in a comparison study of three different bacterial species using transcriptomic and metabolomic approaches. Instead, it is likely that a multitude of genes, proteins, and metabolic pathways influence the physiological state of individual microorganisms in biofilms and contribute to antibiotic tolerance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Microbiology
Arianna Pompilio, Marco Scocchi, Maria Luisa Mangoni, Samira Shirooie, Annalisa Serio, Ygor Ferreira Garcia da Costa, Maria Silvana Alves, Gokce Seker Karatoprak, Ipek Suntar, Haroon Khan, Giovanni Di Bonaventura
Summary: Most human infectious diseases are caused by microorganisms in biofilms, which have increased resistance to antibiotics and the immune system. Therefore, there is a need for new strategies to control biofilm-associated infections. Natural products with a wide range of chemical structures and biological activities have been explored as potential biofilm inhibitors. This review discusses the bioactive compounds isolated from various natural sources that have the potential to inhibit biofilm formation and disperse established biofilms. However, the exact mechanism of action of these compounds is often unclear.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Kelly E. Ormond, Maia J. Borensztein, Miranda L. G. Hallquist, Adam H. Buchanan, William Andrew Faucett, Holly L. Peay, Maureen E. Smith, Eric P. Tricou, Wendy R. Uhlmann, Karen E. Wain, Curtis R. Coughlin
Summary: The research identified core concepts essential for informed consent for genetic testing through an expert consensus process, including the voluntary nature of testing, test recommendations and results, family impact, and potential risks.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Biomedical
Xiaoxia Kang, Xiaoxiao Yang, Conglin Guo, Yuechen Li, Haiwei Ji, Yuling Qin, Li Wu
Summary: Biofilms pose challenges in terms of bacterial characteristics and treatment, thus requiring the development of novel materials and strategies. This review provides a comprehensive summary of effective strategies and methodologies applicable across industries, including the process of biofilms formation, intervention strategies, treatment strategies, and antibacterial substances.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Gorkha Raj Giri, Priti Saxena
Summary: In this study, a novel O-methyltransferase protein called MMAR_2193 from Mycobacterium marinum was characterized, and its multi-methylating ability was revealed. Molecular docking and mass spectrometric analyses identified the possible substrates for MMAR_2193 and confirmed the presence of methylated products in the biofilms of wild type M. marinum.
Article
Biochemical Research Methods
Hannah Boekweg, Amanda J. Guise, Edward D. Plowey, Ryan T. Kelly, Samuel H. Payne
Summary: Single-cell measurements can characterize cell-to-cell heterogeneity, but face challenges in confidently identifying proteome dynamics, requiring sufficient data points across the time course for robust statistical analysis. Important variables include fold change, measurement variability and the number of cells measured during the time course.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Construction & Building Technology
Bart Valks, Monique Arkesteijn, Alexander Koutamanis, Alexandra Den Heijer
Summary: The concept of a 'smart campus' is increasingly attractive in universities worldwide, as it addresses challenges impacting campus development and operation. Smart campus tools are used to support students and employees, optimize space use, and save energy. However, there is still little attention on the use of information provided by these tools and their application in organizational processes. Further research is needed to study the indications and contra-indications of the proposed method.
Review
Immunology
Oyindamola O. Adefisayo, Erin R. Curtis, Clare M. Smith
Summary: The causative agent of tuberculosis, Mycobacterium tuberculosis, has evolved unique phenotypic traits through selective pressures within host cells, contributing to its evolutionary success. Understanding the genetic repertoire used by Mtb to drive virulence and host immune evasion is crucial but remains a challenge. In this review, the employment of mycobacterial genetic tools to study the host-pathogen interaction is evaluated, with a focus on the murine model.
INFECTION AND IMMUNITY
(2023)
Article
Microbiology
Rajagopalan Saranathan, Michael H. Levi, Alice R. Wattam, Adel Malek, Emmanuel Asare, Daniel S. Behin, Debra H. Pan, William R. Jacobs, Wendy A. Szymczak
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Suzanne M. Hingley-Wilson, Nan Ma, Yin Hu, Rosalyn Casey, Anders Bramming, Richard J. Curry, Hongying Lilian Tang, Huihai Wu, Rachel E. Butler, William R. Jacobs, Andrea Rocco, Johnjoe McFadden
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Rebecca A. Luchtel, Tushar Bhagat, Kith Pradhan, William R. Jacobs, Mark Levine, Amit Verma, Niraj Shenoy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Virology
Natalie L. M. Ramsey, Maria Visciano, Richard Hunte, Lip Nam Loh, Clare Burn Aschner, William R. Jacobs, Betsy C. Herold
JOURNAL OF VIROLOGY
(2020)
Article
Chemistry, Organic
Yuji Sumii, Naoyuki Kotoku, Chisu Han, Kentaro Kamiya, Andi Setiawan, Catherine Vilcheze, William R. Jacobs, Masayoshi Arai
TETRAHEDRON LETTERS
(2020)
Article
Microbiology
Catherine Vilcheze, Rajagopalan Saranathan, Brian Weinrick, William R. Jacobs
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Tony W. Ng, Ariel S. Wirchnianski, Anna Z. Wec, J. Maximilian Fels, Christopher T. Johndrow, Kevin O. Saunders, Hua-Xin Liao, John Chan, William R. Jacobs, Kartik Chandran, Steven A. Porcelli
JOURNAL OF IMMUNOLOGY
(2020)
Article
Microbiology
Paras Jain, Spencer Garing, Deepshikha Verma, Rajagopalan Saranathan, Nicholas Clute-Reinig, Jacob Gadwa, Chelsea Peterson, Gleda Hermansky, Anna Astashkina Fernandez, Emmanuel Asare, Torin R. Weisbrod, Ethan Spencer, Claire Mulholland, Michael Berney, David Bell, Kevin P. Nichols, Anne-Laure M. Le Ny, Diane Ordway, William R. Jacobs, Akos Somoskovi, Kyle J. Minch
JOURNAL OF BACTERIOLOGY
(2020)
Article
Immunology
Sangeeta Tiwari, Taru S. Dutt, Bing Chen, Mei Chen, John Kim, Annie Zhi Dai, Regy Lukose, Crystal Shanley, Amy Fox, Burton R. Karger, Steven A. Porcelli, John Chan, Brendan K. Podell, Andres Obregon-Henao, Ian M. Orme, William R. Jacobs, Marcela Henao-Tamayo
Article
Biology
Samuel J. Modlin, Derek Conkle-Gutierrez, Calvin Kim, Scott N. Mitchell, Christopher Morrissey, Brian C. Weinrick, William R. Jacobs, Sarah M. Ramirez-Busby, Sven E. Hoffner, Faramarz Valafar
Article
Immunology
Clare Burn Aschner, Lip Nam Loh, Benjamin Galen, Isabel Delwel, Rohit K. Jangra, Scott J. Garforth, Kartik Chandran, Steven Almo, William R. Jacobs, Carl F. Ware, Betsy C. Herold
SCIENCE IMMUNOLOGY
(2020)
Article
Microbiology
Catherine Vilcheze, Steven A. Porcelli, John Chan, William R. Jacobs
Summary: Study found that specific strains of Mycobacterium tuberculosis can alter their bactericidal properties through leucine and pantothenate auxotrophy, rather than arginine auxotrophy. These triple-auxotrophic strains are crucial for understanding the bacterial and host factors leading to persistent infection of M. tuberculosis as well as for vaccine development studies.
Article
Microbiology
Catherine Vilcheze, William R. Jacobs
Summary: NAC shows boosting activity with TB drugs in vitro, but does not enhance the activity of TB drugs in infected mice models, suggesting differences between in vitro and in vivo effects.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Rajagopalan Saranathan, Emmanuel Asare, Lawrence Leung, Anna Paula de Oliveira, Katherine E. Kaugars, Claire Mulholland, Regy Lukose, Michael Berney, William R. Jacobs
Summary: Optimizing Oxford Nanopore Technology (ONT) allows us to capture the entire genome of herpes simplex virus (HSV) as a single read, and we have reported for the first time the full-length genomes of all four variants. This will contribute to the understanding of the significance and clinical relevance of these variants in HSV-1 infections.
MICROBIOLOGY SPECTRUM
(2022)
Review
Microbiology
Ian L. Sparks, Keith M. Derbyshire, William R. Jacobs Jr, Yasu S. Morita
Summary: Mycobacterium smegmatis is a nonpathogenic and fast growing species that has been elevated to model status for mycobacterial research, providing valuable insights into other pathogens within this genus.
JOURNAL OF BACTERIOLOGY
(2023)