Journal
MOLECULAR MEDICINE REPORTS
Volume 15, Issue 5, Pages 3366-3371Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.6383
Keywords
benzene; fibers; heavy metals; occupational exposure; epigenetics; cancer
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Funding
- Lega Italiana per la Lotta contro i Tumori (LILT)
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The chronic occupational exposure to contaminants and carcinogens leads to the development of cancer. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer. According to the International Agency for Research on Cancer (IARC), the majority of carcinogens are classified as 'probable' and 'possible' human carcinogens, while, direct evidence of carcinogenicity is provided in epidemiological and experimental studies. Additionally, accumulating evidence suggests that epigenetic alterations may be early indicators of genotoxic and non-genotoxic carcinogen exposure. In the present review, the relationship between exposures to benzene, mineral fibers, metals and epigenetic alterations are discussed as the most important cancer risk factors during work activities.
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