Article
Biochemistry & Molecular Biology
Hebatalla Said Ali, Mariam Sameh Boshra, Sara H. A. Agwa, Mohamed S. Abdel Hakeem, Mahmoud Shawky El Meteini, Marwa Matboli
Summary: This study identified a group of differentially expressed mRNAs related to the cGAS/STING, NOD-like receptor pathways (NLR), and T2DM using a microarray dataset. Comparative analysis using real-time PCR revealed significantly higher expressions of ZBP1, DDX58, NFKB1, and CHUK in the prediabetes group compared to healthy controls or T2DM patients. The expressions of ZBP1 and NFKB1 mRNA could discriminate between good and poor glycemic control groups.
Article
Medicine, Research & Experimental
Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Ronn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Asa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L. S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Summary: Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic beta cells. Through studying human pancreatic islets, we identified 395 differentially expressed genes (DEGs) in individuals with T2D, including novel and previously identified candidates. Some of these genes may predispose to diabetes and are associated with HbA1c levels. Most DEGs were expressed in human beta cells and displayed alterations in open chromatin and T2D SNPs. Mouse KO strains demonstrated the regulation of glucose homeostasis and body composition by these T2D-associated candidate genes. Functional validation showed impaired insulin secretion and severe mitochondrial dysfunction in beta cells. Finally, PAX5 was identified as a potential transcriptional regulator of many T2D-associated DEGs in human islets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kun Cui, Zhizheng Li
Summary: Autophagy, an innate safeguard mechanism, is associated with the survival of pancreatic β cells and the development of type 2 diabetes mellitus. This study identified potential autophagy-related biomarkers for the treatment of T2DM through bioinformatics analysis and experimental validation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Alexandra Fahrner, Nikoleta Alchus Laiferova, Barbara Ukropcova, Jozef Ukropec, Jan Krutzfeldt
Summary: Type 2 diabetes negatively affects muscle health. Paracrine signaling in the adult muscle stem cells niche is activated in T2D. The PDGF-miR-501 signaling pathway could be used to classify patients in clinical trials aiming to improve muscle health and glucose homeostasis in diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Zaihan Zhu, Yanfen Zhang, Ruocen Bai, Ru Yang, Zhongyan Shan, Chunyan Ma, Jun Yang, Dandan Sun
Summary: This study found that miRNA polymorphisms involved in the insulin signaling pathways and the interaction effects of SNP-SNP, SNP-environmental factors were related to T2DM susceptibility in a Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mustansir Bhori, Varuni Rastogi, Kanchanlata Tungare, Thankamani Marar
Summary: This study highlights the influence of environmental factors on the gene-disease relationship and how genetic factors may alter the environment-disease relationship. It suggests the need to focus on the combined influence of genetic variants and environmental factors on the occurrence of type 2 diabetes mellitus, instead of studying them separately in order to better understand the synergistic effects of the two factors.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Neurosciences
Shiheng Lu, Hui Wang, Jian Zhang
Summary: In this study, advanced machine learning methods were used to identify key functions and biological processes related to uveitis, providing a theoretical foundation for the clinical treatment of the disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Erik Huckvale, Hunter N. B. Moseley
Summary: Researchers have developed a Python package called kegg_pull that provides improved access and utilization of the KEGG database. It includes both an API and a command line interface, allowing users to download and save an arbitrary number of KEGG entries. The package also offers efficient utilization of multiple CPU cores and provides recommendations for optimal usage based on network and computational circumstances.
BMC BIOINFORMATICS
(2023)
Article
Medicine, Research & Experimental
Siquan Zhang, Yinuo Hong, Huafeng Liu, Qianpeng Wang, Juan Xu, Yujuan Zhang, Xi Zhao, Yan Yao, Kexing Zhou, Xianfeng Ding
Summary: The study identified miR-584 and miR-146a as significantly downregulated in the serum of patients with ARDS, suggesting their association with ARDS and potential therapeutic targets.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Analytical
Yan Sun, Yong-Xia Xu, Nan Wang, Feng Wang, Can-Can Hui, Yu-Wei Cheng, Meng-Jie Cui, Qin-Yi Huang, Jian-Guo Xu, Xiao-Ming Kong
Summary: We developed a time-resolved strand displacement amplification (TR-SDA) method for the molecular detection of miR-146a, a potential biomarker for Type 2 diabetes mellitus (T2DM). The method relies on the use of a multi-functionalized cytosine-rich hairpin probe (C-HP) that enables both intra- and intermolecular replications, leading to a time-resolved amplification pattern. The detection of miR-146a is achieved by detecting the fluorescence emission of G-quadruplex after intercalation with ThT.
Review
Physiology
Karoline Felisbino, Juliano Gomes Granzotti, Larissa Bello-Santos, Izonete Cristina Guiloski
Summary: Polyphenols and other bioactive compounds play a significant role in the prevention and treatment of type 2 diabetes mellitus and its complications, improving blood glucose levels, inhibiting inflammatory responses, increasing mitochondrial function, and exerting their effects by activating or inhibiting relevant genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Feifei Hu, Lei Liu, Zhijian Liu, Mingfeng Cao, Guanghong Li, Xinhuan Zhang
Summary: The circulating microRNA expression profile in type 2 diabetic patients with acute ischemic cerebrovascular disease was comprehensively evaluated through systematic evaluation and meta-analysis. Upregulation of miR-200a, miR-144, and miR-503, and downregulation of miR-126 were observed in type 2 diabetes mellitus patients with acute ischemic cerebrovascular disease. These microRNAs may have diagnostic value in the early identification of this condition.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaorong Yang, Hui Chen, Dandan Zhang, Lin Shen, Guipeng An, Shaohua Zhao
Summary: This study aimed to estimate the spatiotemporal patterns and risk factors of infective endocarditis globally, revealing a continuous rise in both incidence and mortality over the past 30 years, especially in higher SDI regions. The burden of IE among older age groups has been increasing gradually.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Oncology
Songbo Li, Hui Chen, Tongchao Zhang, Rongrong Li, Xiaolin Yin, Jinyu Man, Qiufeng He, Xiaorong Yang, Ming Lu
Summary: Uterine cancer is one of the most common female cancers worldwide, with significant heterogeneity in incidence and mortality. A high body-mass index (BMI) is linked to uterine cancer, but there is limited systematic reporting on this association. Incidence rates in developed areas are significantly higher than in developing regions and are increasing more rapidly. Elderly females, especially those with a high BMI, have a higher risk of uterine cancer.
Article
Oncology
Zhen Li, Yuan Fang, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Xiaorong Yang, Ming Lu
Summary: This study aimed to estimate the latest magnitudes and temporal trends of melanoma burden at the national, regional, and global levels. The results showed that the incidence, deaths, and disability-adjusted life-years (DALYs) of melanoma have been increasing globally, but with significant variations across regions. High burden areas are experiencing a continuing increase in incidence, indicating the need for targeted strategies to reduce the burden.
Article
Oncology
Yuan Fang, Zhen Li, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Xiaorong Yang, Ming Lu
Summary: The incidence, mortality, and burden of lung cancer in China have been increasing over the past three decades, with a more noticeable increase in incidence among females. Smoking remains the leading cause of lung cancer burden, but the contribution of ambient particulate matter pollution has also been increasing.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Huangbo Yuan, Tao Qing, Sibo Zhu, Xiaorong Yang, Weicheng Wu, Kelin Xu, Hui Chen, Yanfeng Jiang, Chengkai Zhu, Ziyu Yuan, Tiejun Zhang, Li Jin, Chen Suo, Ming Lu, Xingdong Chen, Weimin Ye
Summary: Defects in DNA damage repair pathways can lead to genomic instability and oncogenesis. DDR alterations in esophageal squamous cell carcinoma (ESCC) affect mutational processes and tumor immune microenvironment.
Article
Medicine, General & Internal
Xiaorong Yang, Shaohua Zhao, Shaohua Wang, Xuelei Cao, Yue Xu, Meichen Yan, Mingmin Pang, Fan Yi, Hao Wang
Summary: This study aimed to comprehensively assess the association between systemic inflammatory indicators and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia. The results showed that multiple systemic inflammatory indicators were positively correlated with the risk of arrhythmia, with the strongest association found in VA, followed by AF and bradyarrhythmia.
Article
Environmental Sciences
Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Ziyu Yuan, Qiyun Wu, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye
Summary: This study investigated the association between 12 trace elements and gastroesophageal cancers (GOC) using hair and fingernail samples collected from GOC cases and controls in Taixing, China. The results showed that higher levels of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with increased GOC, while higher levels of Mg, Mn, Sr, and As were inversely associated with GOC. Interaction effects between hair level of Cr and smoking or alcohol drinking were also observed.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Biochemical Research Methods
Hongwei Guo, Jinlong Zhao, Xinjun Li, Feifei Sun, Yiming Qin, Xiaorong Yang, Xueting Xiong, Qianshuo Yin, Xueli Wang, Lin Gao, Meng Jiao, Jing Hu, Bo Han
Summary: miR-1-3p, miR-143-3p, and miR-145-5p are associated with bone metastasis in Gleason 3 + 4 prostate cancer. Functional experiments showed that these miRNAs promote proliferation and migration of prostate cancer in vitro. LASP1 was identified as their common target and may activate the Wnt signaling pathway through interaction with I3-β-catenin.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Public, Environmental & Occupational Health
Qianqian Xu, Tingxiao Zhang, Tong Xia, Bin Jin, Hui Chen, Xiaorong Yang
Summary: Over the past 30 years, the burden of kidney cancer in China has gradually increased and is expected to continue rising in the next decade, highlighting the need for more targeted intervention measures.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Tian Ma, Meng Wan, Guanqun Liu, Xiuli Zuo, Xiaorong Yang, Xiaoyun Yang
Summary: This study aims to analyze and predict the epidemiological burden and trends of inflammatory bowel disease (IBD) in China and compare them globally. The findings show that the incidence and prevalence of IBD in China have increased over the years, leading to an increased burden in terms of years of life lost and years lived with disability, while the mortality rate and burden of disability-adjusted life-years have decreased.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Xinyue Zhang, Mengli Li, Wenshuo Dong, Xiaoyan Lv, Li Li, Xiaorong Yang, Yingjuan Cao
Summary: This study investigated the incidence of lower urinary tract symptoms (LUTS) and related risk factors among female nurses in China. The prevalence of LUTS was found to be influenced by factors such as age, Body Mass Index (BMI), marital status, years of working, menstrual status, mode of delivery, history of breastfeeding, history of miscarriage, history of alcohol and coffee or tea consumption, as well as anxiety, depression, and perceived stress. It is important for female nurses to focus on their reproductive health and develop healthy lifestyle habits.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Xuening Zhang, Xiaorong Yang, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ming Lu
Summary: Educational attainment is related to the risk of esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease. Genetically predicted higher educational attainment has a protective effect on these diseases, partly mediated by reducing adiposity, smoking, and depression.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Reproductive Biology
Yana Ma, Jiale Liu, Ning Li, Hualei Bu, Yongwen Huang, Chengjuan Jin, Hao Wen, Shuai Feng, Hui Zhang, Xiaorong Yang, Beihua Kong, Lingying Wu, Kun Song
Summary: There is no significant difference in therapeutic effect between PARPi monotherapy and platinum-based chemotherapy for BRCA1/2-mutated ovarian cancer patients with secondary platinum-sensitive relapse, and PARPi could improve prognosis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Immunology
Xiaorong Yang, Lejin Yang, Tongchao Zhang, Hong Zhang, Hui Chen, Xiuli Zuo
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Shichao Liu, Shoucai Zhang, Yingjie Liu, XiaoRong Yang, Guixi Zheng
Summary: This study identified copper-related lncRNAs (CRLs) as prognostic and diagnostic markers in colon adenocarcinoma and provided guidance for individualized immunotherapy.