Article
Biotechnology & Applied Microbiology
Krasimir Kostov, Alexander Blazhev
Summary: This study investigated the serum levels of MMP-1 and TIMP-1 in patients with essential hypertension compared to normotensive individuals. The results showed significantly higher levels of MMP-1 and TIMP-1 in patients with hypertension compared to the control group. The elevated levels of MMP-1 in hypertension may be associated with increased collagen degradation in the cardiovascular extracellular matrix, while the increased levels of TIMP-1 may contribute to the pathological remodeling and fibrosis of the heart and arterial vessels.
BIOENGINEERING-BASEL
(2022)
Article
Multidisciplinary Sciences
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka
Summary: PAD4 contributes to the production of citrullinated proteins as autoantigens in RA. This study showed that autocitrullinated PAD4 can recruit monocytes and induce inflammation in mouse joints. Higher levels of citrullinated PAD4 were found in the synovial fluid of RA patients compared to osteoarthritis patients.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Celina Eckfeld, Benjamin Schoeps, Daniel Haeussler, Julian Fraedrich, Felix Bayerl, Jan Philipp Boettcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krueger
Summary: The study reveals that TIMP-1 interacts with APP family members and triggers monocyte activation, leading to proinflammatory cytokine expression. This mechanism is confirmed in clinical cancer samples and suggests that TIMP-1 can be a potential therapeutic target for inflammatory diseases.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Shan Wan, Jinwei Xie, Yan Liang, Xijie Yu
Summary: Type 2 diabetes is associated with an abnormal accumulation of bone marrow adipose tissue (BMAT) and increased secretion of MCP-1. This study found that MCP-1 originating from BMAT inhibits the proliferation and insulin secretion of islet cells, exacerbating glucose metabolism disorder. Inhibiting MCP-1 signaling can partially restore islet cell function and improve glucose homeostasis.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, General & Internal
Mattias Ulmner, Rachael Sugars, Aron Naimi-Akbar, Nikolce Tudzarovski, Carina Kruger-Weiner, Bodil Lund
Summary: Research findings suggest that certain protein concentrations are significantly related to poor surgical outcomes, while others are not. Bilateral masticatory muscle palpation pain is associated with disc displacement and osteoarthritis diagnoses, which may lead to unfavorable surgical outcomes. The multivariate model indicates that chronic inflammatory arthritis and patient-reported TMJ disability might be related to an unfavorable outcome.
Article
Biochemistry & Molecular Biology
Yuichi Masuda, Shogo Matsuda, Takuya Kotani, Daisuke Nishioka, Shin Ota, Takafumi Hosokawa, Shimon Ishida, Tohru Takeuchi
Summary: This study investigates the pathomechanism of peripheral neuropathy in microscopic polyangiitis (MPA) and identifies potential biomarkers for diagnosis and severity assessment. The study shows that serum levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) is associated with motor neuropathy in MPA and could be a useful biomarker for diagnosing and evaluating the severity of motor neuropathy in MPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Chun-Hua Luo, Yu Shi, Yu-Qi Liu, Qing Liu, Min Mao, Min Luo, Kai-Di Yang, Wen-Ying Wang, Cong Chen, Qin Niu, Ze-Xuan Yan, Jing-Ya Miao, Xiao-Ning Zhang, Hui Zeng, Lei Li, Xiu-Wu Bian, Yi-Fang Ping
Summary: The study revealed a mechanism mediated by IDH mutation status in regulating glioma tissue stiffness through modulating TIMP1 and downstream extracellular matrix components. TIMP1 was identified as an important regulator of tissue stiffness in IDH-wild type gliomas. Knockdown of TIMP1 decreased tissue stiffness, inhibited the expression of tenascin C and fibronectin, and suppressed tumor progression, suggesting that TIMP1 could be a potential therapeutic target for IDH-WT gliomas.
LABORATORY INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Venkatesh Sadananda Rao, Qianyu Gu, Sandra Tzschentke, Kuailu Lin, Nicole Ganig, May-Linn Thepkaysone, Fang Cheng Wong, Heike Polster, Lena Seifert, Adrian M. Seifert, Nathalie Buck, Carina Riediger, Jonas Weisse, Tony Gutschner, Susanne Michen, Achim Temme, Martin Schneider, Franziska Baenke, Juergen Weitz, Christoph Kahlert
Summary: This study reveals the important role of EV-mediated ECM remodeling in colorectal cancer liver microenvironment and identifies EV-associated TIMP1 as a potential therapeutic target and a circulating biomarker for preoperative risk stratification in patients with colorectal liver metastases.
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Review
Immunology
Zhuqing Jin, En Zheng, Candice Sareli, Pappachan E. Kolattukudy, Jianli Niu
Summary: Inflammatory response is a protective mechanism of the host, but can also lead to immunopathology and tissue damage. Recent studies on the MCPIP family of chemical molecules, particularly the role of MCPIP-1 in the NF kappa B signaling pathway, have revealed important biological functions in resolving inflammation. Understanding the roles of the MCPIP family members can provide new insights into the treatment of infections and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Nigel A. Morrison, Mark R. Forwood
Summary: In this study, the effects of different cytokines on the expression of chemokines in human CD14(+) cells in culture were investigated. It was found that M-CSF treatment promoted MCP1 expression, while GM-CSF suppressed MCP1 expression. Furthermore, addition of MCP1 significantly increased osteoclast formation and overcame the suppression caused by GM-CSF.
Article
Ophthalmology
Richard F. Spaide
Summary: The mutation in the gene responsible for TIMP-3 in patients with Sorsby macular dystrophy may lead to abnormally high levels of TNF alpha in the eye. Adalimumab's direct inhibition of TNF alpha offers a targeted approach to the disease pathophysiology and shows promising efficacy.
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yong Zhao, Wenjia Chen, Yue Liu, Hui Li, Jinyu Chi, Qing Chang, Li Shen, Runan Yan, Jiashu Li, Xinhua Yin, Yu Fu
Summary: The study demonstrates that MCP-3 and TFPI can both reduce the plaque area and decrease lipid and macrophage content, while increasing fibrous cap thickness, collagen, and smooth muscle cell content. TFPI exerts its anti-atherosclerotic effects by inhibiting the MCP-3/CCR2 pathway.
JOURNAL OF DRUG TARGETING
(2021)
Article
Medicine, General & Internal
Hiba Abdullah Mohammed, Ali Abbas Abdulkareem, Faraedon Mostafa Zardawi, Sarhang Sarwat Gul
Summary: This study showed that salivary biomarkers have high diagnostic accuracy in diagnosing periodontitis and distinguishing different stages. TIMP-1 can differentiate between S1 and S3 stages.
Article
Cell & Tissue Engineering
Long Wang, Hong-Yang Zhang, Bo Gao, Jun Shi, Qiang Huang, Yue-Hu Han, Ya-Qian Hu, Wei-Guang Lu, Zhuo-Jie Zhao, Bao-Hua Liu, Qiang Jie, Liu Yang, Zhuo-Jing Luo
STEM CELLS AND DEVELOPMENT
(2017)
Article
Cell Biology
Bo Gao, Xisheng Lin, Huan Jing, Jing Fan, Chenchen Ji, Qiang Jie, Chao Zheng, Di Wang, Xiaolong Xu, Yaqian Hu, Weiguang Lu, Zhuojing Luo, Liu Yang
Article
Medicine, General & Internal
Chao Zheng, Xisheng Lin, Xiaolong Xu, Cheng Wang, Jinru Zhou, Bo Gao, Jing Fan, Weiguang Lu, Yagian Hu, Qiang Jie, Zhuojing Luo, Liu Yang
Article
Cell & Tissue Engineering
Weiguang Lu, Bo Gao, Jing Fan, Pengzhen Cheng, Yaqian Hu, Qiang Jie, Zhuojing Luo, Liu Yang
STEM CELLS INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Chao Zheng, Xisheng Lin, He Liu, Weiguang Lu, Xiaolong Xu, Di Wang, Bo Gao, Cheng Wang, Jinru Zhou, Jing Fan, Yaqian Hu, Qiang Jie, Di Chen, Liu Yang, Zhuojing Luo
Article
Orthopedics
Bo Gao, Jinhua Yin, Xiaolong Xu, Jing Fan, Di Wang, Chao Zheng, Weiguang Lu, Pengzhen Cheng, Jicheng Sun, Dong Wang, Lu Li, Bo O. Zhou, Liu Yang, Zhuojing Luo
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2020)
Article
Oncology
Yaqian Hu, Long Wang, Zhuojie Zhao, Weiguang Lu, Jing Fan, Bo Gao, Zhuojing Luo, Qiang Jie, Xiaojuan Shi, Liu Yang
MOLECULAR MEDICINE REPORTS
(2020)
Correction
Multidisciplinary Sciences
Bo Gao, Qiang Huang, Qiang Jie, Wei-Guang Lu, Long Wang, Xiao-Jie Li, Zhen Sun, Ya-Qian Hu, Li Chen, Bao-Hua Liu, Jian Liu, Liu Yang, Zhuo-Jing Luo
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Huanbo Wang, Chao Zheng, Weiguang Lu, Ting He, Jing Fan, Cheng Wang, Qiang Jie, Danny Chan, Kathryn Song Eng Cheah, Liu Yang
Summary: This study examines the role of Hedgehog signaling in the transition from cartilage to bone. The results suggest that Hedgehog signaling plays a crucial role in the differentiation of chondrocytes into osteoblasts, and its regulation is independent of Smo. These findings are of significant importance in understanding bone homeostasis and diseases.
Article
Engineering, Biomedical
Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao, Long Wang, Guoxian Pei, Liu Yang
Summary: This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism, thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Weiguang Lu, Chao Zheng, Hongyang Zhang, Pengzhen Cheng, Sheng Miao, Huanbo Wang, Ting He, Jing Fan, Yaqian Hu, He Liu, Liyuan Jia, Xue Hao, Zhuojing Luo, Jiake Xu, Qiang Jie, Liu Yang
Summary: The imbalance of bone homeostasis leads to bone degenerative diseases, such as osteoporosis. The Hedgehog (Hh) signaling pathway plays a crucial role in limb and joint development, but its specific role in bone homeostasis is not well understood. This study discovered that the Hh signaling pathway is gradually enhanced during osteoclast differentiation, and its inactivation affects osteoclast formation and osteoclast-osteoblast coupling. The study also revealed the positive regulation of osteoclast differentiation by Hh signaling through the transactivation of Traf6 and stabilization of TRAF6 protein. In addition, connective tissue growth factor (CTGF) was identified as a bone formation-stimulating factor regulated by Hh signaling and its loss contributed to osteopenia. This research provides mechanistic and therapeutic insights into osteoporosis by highlighting the importance of Hh signaling in maintaining bone homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)