Article
Medicine, General & Internal
Eabha O'Driscoll, Emily Hughes, Mustapha Irnaten, Markus Kuehn, Deborah Wallace, Colm O'Brien
Summary: Optic nerve head cupping, a feature of glaucoma, is associated with extracellular matrix remodeling and lamina cribrosa fibrosis. Peripapillary atrophy is common in glaucoma and involves the loss of retinal pigment epithelium adjacent to the optic nerve head. Under pro-fibrotic conditions, epithelial cells can undergo epithelial-to-mesenchymal transition and contribute to extracellular matrix fibrosis. This study investigates the role of this process in glaucoma and peripapillary atrophy, demonstrating the presence of retinal pigment epithelium cells in glaucomatous optic nerve heads and the potential of these cells to differentiate into fibroblast-like cells.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Ying Su, Ziyan Tang, Feng Wang
Summary: The study investigated the regulation of LINC01592 on human RPE cells undergoing epithelial-mesenchymal transition induced by TGF-beta 1, finding that LINC01592 overexpression enhanced the process while its inhibition reduced it. This provides a novel treatment approach for proliferative vitreoretinopathy.
Article
Biochemistry & Molecular Biology
Serena Di Vincenzo, Dennis K. Ninaber, Chiara Cipollina, Maria Ferraro, Pieter S. Hiemstra, Elisabetta Pace
Summary: This study found that cigarette smoke inhibits physiological epithelial wound repair by interfering with the normal epithelial-mesenchymal transition process and the Notch-1 pathway.
Review
Respiratory System
Xiaoshan Su, Weijing Wu, Zhixing Zhu, Xiaoping Lin, Yiming Zeng
Summary: Cigarette smoke plays a significant role in the development and progression of COPD by inducing changes in EMT and promoting airway fibrosis and malignant transformation. Understanding the mechanisms and signaling pathways involved in EMT induced by cigarette smoke can provide new directions for the treatment and research of COPD.
RESPIRATORY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jinglou Chen, Nan Rong, Min Liu, Congyue Xu, Jing Guo
Summary: Cigarette smoke exposure promotes prostatic fibrosis. Circ_0001359 derived from CS-WPMY-1-exo contributes to prostatic fibrosis by stimulating epithelial cells phenotypes changes and collagen deposition.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yiwei Yin, Shikun Liu, Hanhan Liu, Wenyi Wu
Summary: The purpose of this study was to investigate the potential of nintedanib as a therapeutic approach to PVR. By assessing the impact of nintedanib on HV-induced EMT in ARPE-19 cells, we found that nintedanib effectively suppressed the proliferation, migration, and contraction of ARPE-19 cells, and attenuated the upregulation of mesenchymal markers. These findings suggest that nintedanib exhibits protective effects against EMT in ARPE-19 cells and could be a promising therapeutic option for PVR.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Ophthalmology
Furong Gao, Lei Wang, Binxin Wu, Qingjian Ou, Haibin Tian, Jingying Xu, Caixia Jin, Jieping Zhang, Juan Wang, Lixia Lu, Guo-Tong Xu
Summary: The research found that replicative senescence in RPE cells leads to an increase in EMT markers, but senescent RPE cells themselves do not undergo EMT. Conditioned medium from senescent cells induce EMT in presenescent RPE cells and accelerates the process of cell senescence.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pei-Li Yao, Vipul M. Parmar, Mayur Choudhary, Goldis Malek
Summary: The expression and activity of NURR1 play critical roles in the physiological and pathological functions of human RPE cells. Targeting NURR1 may have therapeutic potential for AMD by improving EMT, inflammation, and lipid homeostasis in RPE cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Yiwei Yin, Shikun Liu, Li Pu, Jing Luo, Hanhan Liu, Wenyi Wu
Summary: The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells induced by transforming growth factor beta 2 (TGF-02) is a key mechanism in the fibrosis pathogenesis of proliferative vitreoretinopathy (PVR). However, there are few medications that can inhibit proliferative membranes and cell proliferation in the clinic. In this study, nintedanib, a tyrosine kinase inhibitor, was found to inhibit TGF-02-induced EMT in ARPE-19 cells, suggesting its potential as a pharmacological treatment for PVR.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Lei Wang, Jiani Cao, Yaojin Peng, Boqiang Fu, Zibing Jin, Yuntao Hu, Wei Wu, Andy Peng Xiang, Shijun Hu, Junying Yu, Yu Zhang, Jun Wei, Yong Zhang, Qiyuan Li, Jiaxi Zhou, Peijun Zhai, Huanxin Zhu, Lingmin Liang, Aijin Ma, Glyn Stacey, Tongbiao Zhao, Jie Hao
Summary: The guidelines for human retinal pigment epithelial cells in China were jointly drafted by experts from the Chinese Society for Stem Cell Research, aiming to improve quality control and accelerate international standardization.
CELL PROLIFERATION
(2022)
Article
Chemistry, Multidisciplinary
Sun Young Park, Woo Chang Song, Beomjin Kim, Jin-Woo Oh, Geuntae Park
Summary: Nano-GO induces EMT in human RPE cells by regulating phospholipase D signaling, enhancing cell migration ability and collagen gel contraction, leading to intracellular ROS generation. This study provides evidence of adverse health effects of Nano-GO on RPE cells.
Article
Cell Biology
Heather Lyon, Naibo Yin, Ilva D. Rupenthal, Colin R. Green, Odunayo O. Mugisho
Summary: Epithelial-mesenchymal transition (EMT) is involved in various chronic conditions, including retinal diseases. Blocking connexin43 (Cx43) hemichannels can protect against retinal pigment epithelium (RPE) BRB breakdown and attenuate EMT.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Avin Ee-Hwan Koh, Suresh Kumar Subbiah, Aisha Farhana, Mohammad Khursheed Alam, Pooi Ling Mok
Summary: The study investigated the efficacy of conditioned medium (CM) obtained from transgenic human erythropoietin-expressing MSCs (MSCEPO) in protecting human retinal pigment epithelial cells from sodium iodate (NaIO3)-induced cell death. Results showed that MSC-CMEPO provided an enhanced mitigating effect against NaIO3-induced ARPE-19 cell death compared to MSC-CM alone, suggesting a potential future therapy for treating retinal degenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiten R. Sharma, Hina Agraval, Umesh C. S. Yadav
Summary: This study investigates the mechanism of cigarette smoke-induced and galectin-3-mediated epithelial-mesenchymal transition (EMT) in airway epithelial cells (AECs). The results show that cigarette smoke extract (CSE) exposure affects the survival, morphology, migration, invasion, and clonogenicity of AECs, along with an increase in the expression of EMT markers, galectin-3, and RUNX-2. Inhibition or silencing of RUNX-2 downregulates galectin-3 and modulates EMT marker expression, migration, invasion, and clonogenicity in CSE-exposed AECs.
Article
Biochemistry & Molecular Biology
Tzu-Yin Chen, Chia-Hao Liu, Tsung-Hsien Chen, Mei-Ru Chen, Shan-Wen Liu, Pinpin Lin, Kurt Ming-Chao Lin
Summary: The role of epithelial-mesenchymal transition in lung diseases and cancer related to cigarette smoking is significant. Adipose-derived stem cell-conditioned medium shows protective effects against cigarette smoke-induced cell death and EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)