Review
Biotechnology & Applied Microbiology
Zhengxing Zhou, Chengmin Zhang, Zhiyuan Ma, Hu Wang, Biguang Tuo, Xiaoming Cheng, Xuemei Liu, Taolang Li
Summary: Breast cancer is the most common malignant tumor in women, with HER2-positive breast cancer being treatable using targeting strategies for HER2. Although there has been significant progress, challenges such as recurrence, metastasis, and drug resistance remain. Dysfunction of ion channels and transporters may serve as new therapeutic targets.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jisun Hwang, Bohee Jang, Ayoung Kim, Yejin Lee, Joonha Lee, Chungho Kim, Jinmahn Kim, Kyeong Min Moon, Kyuhyung Kim, Ram Wagle, Young-Han Song, Eok-Soo Oh
Summary: The transmembrane domain (TMD) of syndecan-2 specifically regulates receptor cytoplasmic domain function and downstream signaling events controlling cell behavior, as shown through in vivo invertebrate models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hui Chen, Wanyu Xu, Hui Shi, Yan Qiao, Xiaoxiao He, Jing Zheng, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu
Summary: In this study, an artificial transmembrane signal transduction system using DNA-based artificial membrane receptors is described. Through low pH-mediated formation of the i-motif and dimerization of the receptors, fluorescence resonance energy transfer and G-quadruplex/hemin-mediated fluorescence amplification are activated within giant unilamellar vesicles. The study also establishes an intercellular signal communication model using coacervate microdroplets, which activate the dimerization of artificial receptors and subsequent fluorescence production or polymerization in giant unilamellar vesicles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Svenja Kemmer, Mireia Berdiel-Acer, Eileen Reinz, Johanna Sonntag, Nooraldeen Tarade, Stephan Bernhardt, Mirjam Fehling-Kaschek, Max Hasmann, Ulrike Korf, Stefan Wiemann, Jens Timmer
Summary: Breast cancer subtypes differ in their treatment and prognosis due to the expression and activity of different receptors. The HER2 subtype has been successfully targeted with anti-HER2 therapies, and this study explores whether the HER2 receptor and downstream signaling network could be potential therapeutic targets beyond the HER2-positive subtype. The findings suggest that major parts of the intracellular signal transduction network are unchanged between subtypes, and alterations in this network could render anti-HER therapies relevant beyond the HER2-positive subtype.
Article
Chemistry, Multidisciplinary
Lucia Trevisan, Istvan Kocsis, Christopher A. Hunter
Summary: The transmission of chemical signals across lipid bilayer membranes was achieved by using membrane-anchored molecules and an external redox signal delivered by ascorbic acid to trigger membrane translocation in a synthetic transduction system.
CHEMICAL COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Tania Mariastella Caputo, Giovannina Barisciano, Chiara Mule, Angela Maria Cusano, Anna Aliberti, Livio Muccillo, Vittorio Colantuoni, Lina Sabatino, Andrea Cusano
Summary: In this study, we encapsulated Trastuzumab into nanoparticles, referred to as TZPs, using a double emulsion method. Through characterization and experiments, we found that TZPs had higher drug loading and encapsulation efficiency compared to free Trastuzumab, and they could prolong the release of the drug. TZPs exhibited stronger anti-tumor activity in HER2 positive breast cancer cell lines compared to free Trastuzumab. These results suggest that TZPs may have potential advantages in drug delivery in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jie Chen, Jin Zhu, Shuai-Jun Xu, Jun Zhou, Xiao-Fei Ding, Yong Liang, Guang Chen, Hong-Sheng Lu
Summary: TM4SF1 is downregulated in HR(+)HER2(-) breast cancer, and its overexpression suppresses cell proliferation in this cancer subtype.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Ciqiu Yang, Xiaoqi Zhang, Yitian Chen, Peiyong Li, Junsheng Zhang, Aiqi Xu, Na Huang, Minting Liang, Yilin Chen, Kun Wang
Summary: This study compared the survival outcomes of HER2-low and HER2-negative breast cancers and explored the impact of hormone receptor status. The results showed that HER2-low breast cancer had better survival outcomes than HER2-negative breast cancer in patients with early-stage breast cancer, regardless of hormone receptor status.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Mahdieh Rojhannezhad, Bahram M. Soltani, Mohammad Vasei, Nassim Ghorbanmehr, Seyed Javad Mowla
Summary: HER-2/neu gene encodes a protein called HER2 that plays an important role in some cancers. This study used the CRISPR/Cas9 method to knockout a potential enhancer called Her2-Enhancer1 located within the HER2 gene, and investigated its regulatory effects on HER2 and HER2-interacting genes. The findings revealed significant alterations in the expression of HER2 and other target genes, as well as an increase in apoptosis rate. These results suggest the potential of this enhancer as a target for therapy in HER2-positive cancers.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, General & Internal
Ron Bose, Cynthia X. Ma
Summary: A recent study suggests that HER2-mutated breast cancer may develop resistance to drugs that inhibit the tyrosine kinase domain of HER2 through developing mutations in HER3, which enhance the dimerization between HER2 and HER3. The HER3 mutations augment signaling. This study supports a specific approach to overcoming mutant-HER3-mediated resistance.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Chongkai Wang, Marwan Fakih
Summary: Dual HER2-targeted therapy has shown clinical benefits in RAS-wild type HER2-amplified colorectal cancer, but not in cases with HER2 mutations. This case report demonstrates successful HER2 targeting with trastuzumab + lapatinib in metastatic CRC with concurrent HER2 amplification and a HER2 S310F mutation. Treatment with trastuzumab-deruxtecan upon disease progression resulted in a short-lived response.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Biochemistry & Molecular Biology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: Lysophosphatidic acid receptors (LPARs) play a role in promoting tumorigenesis and therapy resistance in various cancer subtypes. Our study found that increased expression of LPAR1, LPAR4, and LPAR6 correlated with a less aggressive phenotype, while high expression of LPAR2 was associated with increased tumor grade, mutational burden, and decreased survival. Different LPARs were also expressed in different cell types, suggesting potential compensatory signaling in LPAR inhibitor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Santiago Duro-Sanchez, Macarena Roman Alonso, Joaquin Arribas
Summary: A variety of treatments are available for HER2-positive breast cancer, but resistance to these therapies is common and associated with poor prognosis. Immunotherapeutic approaches are being explored to eradicate tumor cells and prevent relapse and progression. This review discusses the different immunotherapeutic strategies being tested and their potential benefits for HER2-positive breast cancer.
Article
Cell Biology
Yi-Fong Chen, Yung-Ning Yang, Hung-Ru Chu, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis
Summary: The study reveals that doxycycline inhibits proliferation and downregulates PD-L1 gene expression in breast cancer cells, possibly by interacting with integrin alpha v beta 3 and inhibiting ERK1/2 activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Adam-Artigues, Enrique J. Arenas, Alex Martinez-Sabadell, Fara Braso-Maristany, Raimundo Cervera, Eduardo Tormo, Cristina Hernando, Maria Teresa Martinez, Juan Carbonell-Asins, Soraya Simon, Jesus Poveda, Santiago Moragon, Sandra Zazo, Debora Martinez, Ana Rovira, Octavio Burgues, Federico Rojo, Joan Albanell, Begona Bermejo, Ana Lluch, Aleix Prat, Joaquin Arribas, Pilar Eroles, Juan Miguel Cejalvo
Summary: AXL overexpression is identified as an essential mechanism of trastuzumab resistance in HER2-positive breast cancer, and targeting AXL can restore trastuzumab response. AXL may serve as a predictive biomarker for prognosis in HER2-positive breast cancer patients. The study emphasizes the importance of targeting AXL in combination with anti-HER2 drugs to overcome resistance.
Article
Biochemistry & Molecular Biology
Cong Chen, Huanqing Zhu, Jiaxin Kang, Hasitha Kalhari Warusawitharana, Shuna Chen, Kaixi Wang, Fei Yu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: This study provides a comprehensive understanding of saponin biosynthesis and accumulation in tea plants, identifying key enzymes and transcription factors involved in saponin biosynthesis through analysis of tea flower and seed samples. The mevalonate pathway, along with HMGS, MVD, IDI enzymes, were found to be responsible for saponin accumulation, highlighting the potential regulatory role of ten transcription factors in tea plant saponin biosynthesis.
Editorial Material
Ecology
Ming Nie, Wenwen Liu, Steven C. Pennings, Bo Li
Review
Food Science & Technology
Yang Wang, Xiang Luo, Li Chen, Abdullateef Taiye Mustapha, Xiaojie Yu, Cunshan Zhou, Clinton Emeka Okonkwo
Summary: For health and safety reasons, natural and low-calorie sweeteners are replacing traditional high-calorie and artificial sweeteners in the food industry. Steviol glycosides, particularly rebaudioside A, are gaining popularity as a natural and high-quality sugar substitute due to their safe, zero-calorie, and sweet taste without undesirable characteristics. They have various physiological functions and potential health benefits such as antihypertensive, anti-diabetic, and anticaries effects. This review article provides comprehensive information on the physicochemical properties, metabolic process, safety, regulatory aspects, health benefits, biosynthetic pathway, production methods, and purification techniques of rebaudioside A. It also highlights the current challenges hindering its production and application.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Chemistry, Physical
Jing Xue, Xiaojie Yu, Mingxiao Yao, Haijun Huang
Summary: In-situ hybrid (Al3Ni+Al2O3)/Al composites with bimodal size particles distributions were fabricated via an Al-NiO solid-state combustion reaction and subsequent hot extrusion process. The mechanical properties of the composites were significantly enhanced due to the introduction of Al3Ni and Al2O3 particles. The strength of the composites could be increased without a sacrifice in fracture toughness by increasing the NiO content.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Multidisciplinary Sciences
Xiaojie Yu, Christian M. Orr, H. T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie, Mark S. Cragg
Summary: Low affinity of immunomodulatory antibodies leads to greater activity through increased clustering, resulting in higher immune cell activation, T cell expansion, and antitumor activity. This discovery reveals a new mechanism for enhancing receptor activation across diverse receptor families and sheds light on the mechanism of antibody-mediated receptor signaling. Affinity engineering offers a rational, efficient, and tunable solution for delivering antibody-mediated receptor activity for the treatment of human disease.
Article
Immunology
Guangyao Li, Kewen Qian, Shuyi Zhang, Wenyan Fu, Jian Zhao, Changhai Lei, Shi Hu
Summary: SARS-CoV-2 invades the human body by binding to ACE2 receptors, and the interaction of receptor-binding sites is a hot topic in coronavirus drug development. Monoclonal antibody therapy is showing signs of slowing, while recombinant soluble ACE2 therapy has great potential for neutralizing coronaviruses but its clinical development progress is stalled. Therefore, key problems need to be solved for recombinant soluble ACE2 to be approved as a clinical treatment as soon as possible.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xiaojie Yu, Yuting Wang, Yifan Song, Xianda Gao, Hongkui Deng
Summary: Aging is characterized by chronic low-grade inflammation in multiple tissues, also termed inflammaging, which represents a significant risk factor for many aging-related chronic diseases. However, the mechanisms and regulatory networks underlying inflammaging across different tissues have not yet been fully elucidated. Here, we profiled the transcriptomes and epigenomes of the kidney and liver from young and aged mice and found links between transcriptome changes and chromatin dynamics through integrative analysis. We identified AP-1 and ETS family transcription factors as potential regulators of inflammaging and demonstrated that genetic knockdown of Fos, a major member of the AP-1 family, significantly attenuated the inflammatory response in aged kidneys and livers.
Review
Environmental Sciences
Qinghua Ji, Xiaojie Yu, Li Chen, Abdullateef Taiye Mustapha, Clinton Emeka Okonkwo, Cunshan Zhou, Xianming Liu
Summary: Converting biomass to renewable chemicals is important for green chemistry and sustainable chemical industry. Lignin, as the main component of biomass, is a abundant natural polyphenol with unique properties. Different methods of lignin depolymerization, including thermochemical, chemical catalysis, electrocatalysis, and biological depolymerization, have been extensively explored. This review focuses on the catalytic reaction systems, degradation products, reaction mechanisms, and the effects of green-deep eutectic solvents on lignin depolymerization. Each method has its own advantages and disadvantages, and the selection of biomass lignin should consider its compositional structure for efficient depolymerization. The challenges and future prospects of biomass lignin depolymerization are also discussed.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Food Science & Technology
Yuqing Wang, Long Zhang, Xiaojie Yu, Cunshan Zhou, Abu ElGasim Ahmed Yagoub, Dajing Li
Summary: The preservation and processing of fruits and vegetables require high-quality raw materials, and blanching in hot water is a common pre-treatment method. Traditional blanching has drawbacks of high water and energy usage, as well as poor product quality. However, the new technology of catalytic infrared blanching offers homogeneous heating, rapid heat transmission, and high-quality products with low energy consumption and environmental preservation. Recent research has focused on combining infrared technology and catalytic infrared processing to enhance flexibility and durability.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Shuna Chen, Jiaxin Kang, Huanqing Zhu, Kaixi Wang, Ziyi Han, Leyu Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: L-theanine is the main amino acid in tea leaves and has both flavor and health benefits. Its immunomodulatory effects, particularly on reducing immunosuppression and improving immunity, have been studied in clinical and epidemiological research. Numerous studies on cells and animals have also shown that theanine plays a role in regulating inflammation, nerve damage, the intestinal tract, and tumors by regulating certain cellular functions.
Review
Biochemistry & Molecular Biology
Hongbo Chen, Fei Yu, Jiaxin Kang, Qiao Li, Hasitha Kalhari Warusawitharana, Bo Li
Summary: The composition and contents of organic acids vary in different types of tea. They play important roles in the metabolism of tea plants, nutrient absorption and growth regulation, as well as the aroma and taste quality of tea. However, the research on organic acids in tea is still limited. This article reviewed the progress made in studying organic acids in tea, including analysis methods, physiological functions, composition and influencing factors, sensory contributions, as well as health benefits like antioxidation and digestion promotion. It aims to provide references for further research on organic acids in tea.
Article
Plant Sciences
Yuanfei Pan, Mu Liu, Alejandro Sosa, Bo Li, Mang Shi, Xiaoyun Pan
Summary: This study investigates the metacommunities of endophytic fungi in the leaves of an invasive plant and finds that the structure of these fungal communities is influenced by multiple spatial scales and different drivers. These findings are important for understanding the global patterns of fungal diversity.
Article
Green & Sustainable Science & Technology
Aiping Lu, Xiaojie Yu, Li Chen, Clinton Emeka Okonkwo, Phyllis Otu, Cunshan Zhou, Qiaomin Lu, Qiaolan Sun
Summary: This study evaluated the effectiveness of a novel deep eutectic solvent (DES) composed of guaiacol (GG) and p-hydroxybenzoic acid (PB) as hydrogen bond donors, and choline chloride (ChCl) as a hydrogen bond receptor, in the structural properties and enzymatic hydrolysis of peanut shell. The ChCl-GG-PB pretreatment effectively removed hemicellulose and lignin, resulting in a significant improvement in enzymatic glycosaccharification efficiency. Furthermore, the ChCl-GG-PB pretreatment induced significant changes in structure and morphology, with the highest crystal-linity and lowest solid recovery.
Article
Computer Science, Interdisciplinary Applications
Xian Song, Bo Li, Pengyu Wang, Yizhao Zhou, Jian Wang, Yaqun Wang, Chengbing Fang, Meiyuan Jin
Summary: This article fabricated a flexible piezoelectric sensor to gather data for the pulse-taking procedure and used it to recognize whether a woman is pregnant. The pulse signal was processed by GoogleNet and achieved a 90.48% correction rate, which solidified the objectivity of pulse diagnosis and raised the digitalization level of TCM.
ENGINEERING REPORTS
(2023)
Article
Remote Sensing
Xi Zhang, Xiangming Xiao, Xinxin Wang, Xiao Xu, Shiyun Qiu, Lianghao Pan, Jun Ma, Ruiting Ju, Jihua Wu, Bo Li
Summary: Biological invasions, especially by Spartina alterniflora, are significantly impacting the structure and functions of coastal ecosystems in China. Urgent efforts to control the spread of this invasive species are hindered by the lack of time-series data. By using satellite images, this study successfully generated annual maps of Spartina saltmarshes from 1985 to 2020, revealing a continuous expansion of Spartina along the coast. The invasion history and frequency of changes were found to be influenced by latitude, with low latitudes experiencing longer and more frequent invasions. Human interventions have contributed to the decline in certain areas, but natural spread remains the primary driver of its extensive invasion.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2023)
