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Biochemistry & Molecular Biology
Shasha Tang, Wenjing Liu, Liyun Yong, Dongyang Liu, Xiaoyan Lin, Yuan Huang, Hui Wang, Fengfeng Cai
Summary: KRT17 expression is closely associated with prognosis in breast cancer, especially in patients with high HER2 expression. KRT17 may be involved in multiple immune pathways and associated with various immune cells. This finding provides a promising biomarker for the diagnosis and prognosis of breast cancer.
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Oncology
Jingyan Xue, Sheng Huang, Jiaying Chen, Yi-zuo Chen, Zhi-min Shao, Jiong Wu, Yayun Chi
Summary: The expression level of Linc01315 is significantly correlated with the prognosis of breast cancer patients, especially in terms of disease-free survival (DFS) and overall survival (OS). Linc01315 may serve as an independent prognostic marker in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lijuan Yang, Haohao Wu, Yan Zhu, Xiaoping Chen, Youguo Chen
Summary: Low levels of exosomal CAV1 in plasma are associated with FIGO stages I/II, low grade, lymph node metastasis, and prognosis in ovarian cancer patients. Plasma exosomal CAV1 may serve as a potential biomarker for predicting the prognosis of ovarian cancer patients.
Article
Biochemistry & Molecular Biology
Kamil Demircan, Qian Sun, Ylva Bengtsson, Petra Seemann, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryd, Waldemar B. Minich, Ake Borg, Jonas Manjer, Lutz Schomburg
Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.
Article
Oncology
Zheng Li, Yaming Li, Xiaolong Wang, Qifeng Yang
Summary: The study identified PPP2R2B as a strong tumor suppressor in TNBC, with downregulated expression in TNBC tissues compared to normal breast tissues. Low PPP2R2B expression was associated with shorter survival time and could play a key role in breast cancer initiation and progression. PPP2R2B was also found to be related to specific immune cells and immune inhibitor genes.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Tiegang Li, Zheng Yan, Weiqi Wang, Rixin Zhang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Min Yang
Summary: The study revealed that high SEMA6B expression was associated with poor prognosis and the tumor immunosuppressive microenvironment in CRC patients, suggesting SEMA6B as a potential novel prognostic biomarker for CRC and providing insights for developing CRC-targeted immunotherapies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hongmei Dong, Liang Du, Songwang Cai, Wan Lin, Chaoying Chen, Matthew Still, Zhimeng Yao, Robert P. Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang
Summary: This study reveals the correlation between PTPRO and lapatinib resistance in ERBB2-positive breast cancer, suggesting that PTPRO can serve as an independent prognostic indicator and upregulating PTPRO can reverse the resistance to lapatinib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Peter Q. Huang, Brant C. Boren, Sayee G. Hegde, Hui Liu, Aditya K. Unni, Sunny Abraham, Chad D. Hopkins, Sunil Paliwal, Ahmed A. Samatar, Jiali Li, Kevin D. Bunker
Summary: Wee1 inhibition has emerged as a promising therapy for cancer treatment in the past decade. Compound 16, a highly selective Wee1 inhibitor with balanced potency and pharmacokinetic properties, has shown excellent in vivo efficacy and is currently in phase 2 clinical trials.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Chang-yi Zhao, Chun-hui Hua, Chang-hua Li, Rui-zhe Zheng, Xin-yuan Li
Summary: This study found that high expression of PYGL is positively associated with glioma malignancy and serves as an independent predictor of poor prognosis in patients with glioma. The study used bioinformatics analysis to identify potential mechanisms underlying the predictive value of PYGL in gliomas, with different gene sets related to signaling pathways and angiogenesis enriched in high PYGL expression phenotype. Single-cell sequencing data analysis further confirmed the high expression of PYGL in specific cell groups, including tumor-associated macrophages and malignant cells.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Sonali Jindal, Nathan D. Pennock, Duanchen Sun, Wesley Horton, Michelle K. Ozaki, Jayasri Narasimhan, Alexandra Q. Bartlett, Sheila Weinmann, Paul E. Goss, Virginia F. Borges, Zheng Xia, Pepper Schedin
Summary: The study reveals that postpartum breast cancer has distinct gene expression characteristics compared to other breast cancers, with poorer prognosis, suggesting it to be a unique entity within young women's breast cancer.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hong Lin, Fangyi Long, Xiqian Zhang, Pinghan Wang, Ting Wang
Summary: Our study constructed 4 prognostic regulatory axes that are significantly correlated with tumor prognosis in breast cancer patients, and uncovered the roles of circ_0008812 and circ_0001583 in breast cancer, providing a new perspective into the molecular mechanisms of breast cancer pathogenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xu Chen, Jing Chen
Summary: This study found that PIEZO1 is overexpressed in human breast cancer and is significantly associated with malignant progression and short-term survival. Downregulation of miR-10b-5p may partially contribute to the upregulation of PIEZO1 in breast cancer. Furthermore, PIEZO1 may exert its function by regulating purine metabolism in breast cancer.
Article
Oncology
Khloud A. Elsharawy, Maryam Althobiti, Omar J. Mohammed, Abrar I. Aljohani, Michael S. Toss, Andrew R. Green, Emad A. Rakha
Summary: NOP10 is a key factor in ribosome biogenesis and telomere maintenance, and its high expression is significantly associated with aggressive features in breast cancer, especially in the triple-negative breast cancer subtype. High NOP10 protein expression is an independent predictor of poor outcome, shorter survival, and higher risks of death and distant metastasis in chemotherapy-treated patients. This suggests that NOP10 may serve as a potential prognostic biomarker and predictive indicator for chemotherapy resistance in breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Multidisciplinary Sciences
Patricia Jaaks, Elizabeth A. Coker, Daniel J. Vis, Olivia Edwards, Emma F. Carpenter, Simonetta M. Leto, Lisa Dwane, Francesco Sassi, Howard Lightfoot, Syd Barthorpe, Dieudonne van der Meer, Wanjuan Yang, Alexandra Beck, Tatiana Mironenko, Caitlin Hall, James Hall, Iman Mali, Laura Richardson, Charlotte Tolley, James Morris, Frances Thomas, Ermira Lleshi, Nanne Aben, Cyril H. Benes, Andrea Bertotti, Livio Trusolino, Lodewyk Wessels, Mathew J. Garnett
Summary: Combinations of anti-cancer drugs can overcome resistance and provide new treatments. This study evaluates 2,025 clinically relevant two-drug combinations and finds that synergy between drugs is rare and context-dependent. The findings can guide the development of combination treatments for specific cancer subtypes.
Article
Oncology
Stefania Pianetti, Kathy D. Miller, Hannah H. H. Chen, Sandra Althouse, Sha Cao, Steven J. Michael, Gail E. Sonenshein, Nora D. Mineva
Summary: Breast malignancies are the leading cause of cancer-related death in women. ADAM8 has been identified as a marker of poor survival and a driver of Triple-Negative Breast Cancer growth. A highly specific IHC assay for detecting ADAM8-positive breast tumors has been developed.
CANCER CELL INTERNATIONAL
(2023)
Article
Pathology
Michael Toss, Islam Miligy, Kylie Gorringe, Karuna Mittal, Ritu Aneja, Ian Ellis, Andrew Green, Emad Rakha
JOURNAL OF CLINICAL PATHOLOGY
(2020)
Editorial Material
Cell Biology
Puay Hoon Tan, Ian Ellis, Kimberly Allison, Edi Brogi, Stephen B. Fox, Sunil Lakhani, Alexander J. Lazar, Elizabeth A. Morris, Aysegul Sahin, Roberto Salgado, Anna Sapino, Hironobu Sasano, Stuart Schnitt, Christos Sotiriou, Paul van Diest, Valerie A. White, Dilani Lokuhetty, Ian A. Cree
Article
Biochemistry & Molecular Biology
Lutfi H. Alfarsi, Rokaya El-Ansari, Madeleine L. Craze, Brendah K. Masisi, Omar J. Mohammed, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Simon J. Johnston, Binafsha M. Syed, Ruth M. Parks, Cintia J. Monteiro, Joseph A. Caruso, Andrew R. Green, Ian O. Ellis, Kelly K. Hunt, Cansu Karakas, Khandan Keyomarsi, Kwok-Leung Cheung
Article
Oncology
Ruth M. Parks, Mohammad Albanghali, Binafsha M. Syed, Andrew R. Green, Ian O. Ellis, Kwok-Leung Cheung
Review
Biochemistry & Molecular Biology
Smarakan Sneha, Simon C. Baker, Andrew Green, Sarah Storr, Radhika Aiyappa, Stewart Martin, Klaus Pors
Summary: Advances in treatment strategies for breast cancer face challenges in achieving selective treatment with limited side effects; The CYP family of enzymes play important roles in cancer cell proliferation, cell signaling, and drug metabolism, impacting treatment outcomes; Understanding CYP expression and its role in metabolizing steroid hormones and xenobiotics is crucial for the pathogenesis of breast cancer.
Review
Pathology
C. van Dooijeweert, P. J. van Diest, I. O. Ellis
Summary: Histologic grading is a simple and cost-effective method to assess tumor behavior in invasive breast cancer, with important prognostic value. Properly performed histologic grading is crucial for guiding treatment decisions in breast cancer patients.
Article
Oncology
Brendah K. Masisi, Rokaya El Ansari, Lutfi Alfarsi, Madeleine L. Craze, Natasha Jewa, Andrew Oldfield, Hayley Cheung, Michael Toss, Emad A. Rakha, Andrew R. Green
Summary: This study aimed to evaluate the expression and prognostic significance of glutaminase in luminal breast cancer. It was found that GLS plays a key role in the biological function of luminal BC, particularly in the early non-invasive stage, which could be used as a potential biomarker to predict disease progression and as a target for inhibition. Further validation and functional assessments are needed to confirm these observations and explore their specific roles.
Article
Genetics & Heredity
Esther Danenberg, Helen Bardwell, Vito R. T. Zanotelli, Elena Provenzano, Suet-Feung Chin, Oscar M. Rueda, Andrew Green, Emad Rakha, Samuel Aparicio, Ian O. Ellis, Bernd Bodenmiller, Carlos Caldas, H. Raza Ali
Summary: Imaging mass cytometry profiling of 693 breast tumors revealed 10 recurrent tumor microenvironment spatial structures, associated with genomic profiles and outcomes. These multicellular structures within the TME, varying in vascular content, stromal activation, and leukocyte composition, could improve patient stratification and link spatial organization to local TME function.
Article
Cell Biology
Islam M. Miligy, Michael S. Toss, Kylie L. Gorringe, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
Summary: High AURKA expression is associated with aggressiveness features in DCIS and may be a predictive marker for DCIS progression to invasive disease.
Article
Biochemistry & Molecular Biology
Qi Xu, Jaspreet Kaur, Dennis Wylie, Karuna Mittal, Hongxiao Li, Rishab Kolachina, Mohammed Aleskandarany, Michael S. Toss, Andrew R. Green, Jianchen Yang, Thomas E. Yankeelov, Shristi Bhattarai, Emiel A. M. Janssen, Jun Kong, Emad A. Rakha, Jeanne Kowalski, Ritu Aneja
Summary: This study explores the intratumoral heterogeneity (ITH) in triple-negative breast cancer (TNBC) by evaluating gene expression and imaging differences within the same tumor. The results show extensive intertumoral heterogeneity and regional ITH in gene expression and image-derived features in TNBC. Concerns are raised regarding gene expression based TNBC subtyping.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ian O. Ellis, Emad A. Rakha, Gary M. Tse, Puay Hoon Tan
Summary: The International Collaboration on Cancer Reporting (ICCR) has developed an international dataset for breast cancer pathology reporting, aiming to provide a unified approach worldwide. The dataset includes essential and optional data items based on a critical review and discussion of current evidence. The process concludes with international public consultation and publication on the ICCR website to promote high-quality, standardised pathology reporting globally.
Article
Oncology
Yousif A. Kariri, Chitra Joseph, Mansour A. Alsaleem, Khloud A. Elsharawy, Sami Alsaeed, Michael S. Toss, Nigel P. Mongan, Andrew R. Green, Emad A. Rakha
Summary: Breast cancer exhibits genetic and clinical heterogeneity. This study evaluates the prognostic and biological value of Cell Division Cycle Associated 5 (CDCA5) in breast cancer. The results demonstrate that CDCA5 plays an important role in breast cancer development and metastasis, and could be used as a potential biomarker for disease progression.
Article
Economics
Ahmed Rakha, Hansi Hettiarachchi, Dina Rady, Mohamed Medhat Gaber, Emad Rakha, Mohammed M. Abdelsamea
Summary: This study aims to assess the economic impacts of COVID-19 in the UK using AI and past economic crisis data to predict future impacts. By analyzing macroeconomic indicators and industry performance data, it predicts -8.5% GDP growth in 2021 compared to pre-pandemic levels, with no quarterly GDP drops after Q1 2021.
Article
Health Care Sciences & Services
Stephen Duffy, Daniel Vulkan, Howard Cuckle, Dharmishta Parmar, Shama Sheikh, Robert Smith, Andrew Evans, Oleg Blyuss, Louise Johns, Ian Ellis, Peter Sasieni, Chris Wale, Jonathan Myles, Sue Moss
HEALTH TECHNOLOGY ASSESSMENT
(2020)