Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Paul Kawak, Nour M. Al Sawaftah, William G. Pitt, Ghaleb A. Husseini, Christian Celia, Chiara Laezza
Summary: Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options due to the blood-brain barrier (BBB). Liposomes offer potential solutions to the limitations of chemotherapy, but passive targeting strategies have been ineffective. The upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics, which show promise in GBM therapy. This review discusses the role of Tf-conjugated liposomes in GBM therapy, recent studies on their drug delivery efficiency, challenges faced, and potential improvements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ahmed M. Shabana, Siva P. Kambhampati, Ru-ching Hsia, Rangaramanujam M. Kannan, Efrosini Kokkoli
Summary: The translated system enhances the delivery of gemcitabine and paclitaxel to pancreatic cancer, effectively killing cancer cells and inhibiting tumor growth with sustained release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ahmed M. Shabana, Beibei Xu, Zachary Schneiderman, Jun Ma, Clark C. Chen, Efrosini Kokkoli
Summary: The study explores a miRNA delivery strategy for treating glioblastoma, involving complexation with PEI and encapsulation in targeted liposomes, resulting in increased intracellular miRNA levels, and decreased signaling pathways.
Article
Biochemistry & Molecular Biology
Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh
Summary: BDNF delivered through lipid-based nanoparticles shows promising results in Alzheimer's Disease animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Chengyuan Huang, Xuan Zhao, Meiling Su, Zongning Yin
Summary: The novel ultrasmall micelles, with specific affinity to podocytes mediated by a novel linear RWrNM peptide, demonstrated promising drug delivery strategy for actively targeted therapy of CKD in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Hiroaki Echigo, Kenji Mishiro, Takeshi Fuchigami, Kazuhiro Shiba, Seigo Kinuya, Kazuma Ogawa
Summary: Novel radiolabeling method was developed for I-125 and At-211-labeled RGD peptides, showing high accumulation in tumor tissues and similar biodistribution. Dimer RGD peptides demonstrated improved affinity with alpha(v)beta(3) integrin, leading to higher accumulation in tumor tissues. Furthermore, experiments showed significantly increased accumulation of I-125-labeled dimer RGD peptide in tumors compared to monomer RGD peptide.
Article
Chemistry, Multidisciplinary
Yadan Zhang, Junlin He, Liao Shen, Tao Wang, Jun Yang, Yao Li, Yongan Wang, Dongqin Quan
Summary: The study developed transferrin receptor aptamer-functionalized liposomes (Apt-LP) to deliver AChE reactivator across the blood-brain barrier, showing promising results in treating organophosphorus poisoning by improving drug transport efficiency to the brain.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Article
Chemistry, Multidisciplinary
Kai Wang, Uday S. Kumar, Negar Sadeghipour, Tarik F. Massoud, Ramasamy Paulmurugan
Summary: A scalable microfluidic platform was developed to load therapeutic miRNAs and drugs into EVs while controlling their size, leading to improved treatment outcomes in orthotopic GBM mouse models. The engineered mpEVs demonstrated efficient delivery of miRNAs and drugs to GBM cells, resulting in tumor regression and increased survival rates in mice, showing potential for clinical translation in GBM therapy.
Article
Chemistry, Multidisciplinary
Hua Zhang, Wei-Lun Tang, Azadeh Kheirolomoom, Brett Z. Fite, Bo Wu, Kenneth Lau, Mo Baikoghli, Marina Nura Raie, Spencer K. Tumbale, Josquin Foiret, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, R. Holland Cheng, Alexander D. Borowsky, Katherine W. Ferrara
Summary: A formulation using R848-loaded thermosensitive liposomes (TSLs) was developed for intravenous delivery, showing efficacy in tumor regression and enhanced survival when combined with alpha PD-1 in mouse models of breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Una Janke, Alexandra Mitlehner, Aileen Weide, Theresia Gutmann, Mihaela Delcea
Summary: The importance of studying the platelet receptor integrin alpha IIb beta 3 in a membrane-mimetic environment without interfering signalling pathways lies in gaining a better understanding of protein structure and dynamics. By reconstituting the receptor in model membranes mimicking the plasma membrane, insights into integrin reconstitution efficiency and conformational dynamics can be obtained, offering a useful platform for dissecting disease-relevant integrin mutations and effects on ligand binding in a lipid-specific context, potentially applicable for drug screening.
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yu Long, Fuqiang Shao, Hao Ji, Xiangming Song, Xiaoying Lv, Xiaotian Xia, Qingyao Liu, Yongxue Zhang, Dexing Zeng, Xiaoli Lan, Yongkang Gai
Summary: Ovarian cancer has the highest mortality rate among gynecologic malignancies. Ga-68-NGR-RGD, a tracer targeting CD13 and integrin alpha(v)beta(3), shows better contrast and improved ability to differentiate inflammation compared to F-18-FDG in ovarian cancer imaging. It presents a promising imaging agent for the diagnosis, staging, and follow-up of ovarian tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Article
Pharmacology & Pharmacy
J. S. Dileep Kumar, Jaya Prabhakaran, Andrei Molotkov, Anirudh Sattiraju, Jongho Kim, Mikhail Doubrovin, J. John Mann, Akiva Mintz
PHARMACOLOGICAL REPORTS
(2020)
Article
Engineering, Biomedical
Michael J. Merrick, David A. Rotsch, Ashok Tiwari, Jerry Nolen, Thomas Brossard, Jeongseog Song, Thaddeus J. Wadas, John J. Sunderland, Stephen A. Graves
Summary: The study evaluated the imaging and dosimetric characteristics of Cu-67, and reported the first SPECT/CT imaging using Cu-67. The production and clinical imaging of Cu-67 appeared feasible, indicating potential applications in radiopharmaceuticals for therapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narges K. Tafreshi, Darpan N. Pandya, Christopher J. Tichacek, Mikalai M. Budzevich, Zhen Wang, Jordan N. Reff, Robert W. Engelman, David C. Boulware, Alberto A. Chiappori, Jonathan R. Strosberg, Haitao Ji, Thaddeus J. Wadas, Ghassan El-Haddad, David L. Morse
Summary: The study demonstrates significant potential for the clinical translation of [Ac-225]Ac-DOTA-TATE for lung NENs, showing notable tumor growth delay and prolonged time to experimental endpoint.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Chirayu M. Patel, Thaddeus J. Wadas, Yusuke Shiozawa
Summary: Bone metastasis is a major cause of death in cancer patients, and current therapies are mainly palliative. However, systemic radiotherapy shows potential for improving overall survival in patients.
Article
Physics, Multidisciplinary
Michael J. Merrick, David A. Rotsch, Ashok Tiwari, Jerry Nolen, Thomas Brossard, Jeongseog Song, Thaddeus J. Wadas, John J. Sunderland, Stephen A. Graves
Summary: The half-life of Cu-67 was determined with high precision through gamma-ray spectrometry measurements and least-squares regression analysis, resulting in a value of 61.761 +/- 0.004 hours. This represents a significant improvement over current data and marks a new level of accuracy in the field.
JOURNAL OF PHYSICS COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Fan Lam, James Chu, Ji Sun Choi, Chang Cao, T. Kevin Hitchens, Scott K. Silverman, Zhi-Pei Liang, Ryan N. Dilger, Gene E. Robinson, King C. Li
Summary: This study presents a new method called epigenetic MRI (eMRI) that allows nondestructive measurement of global gene expression in the brain by directly imaging DNA methylation. The method uses C-13-enriched diets to label DNA through methionine metabolic pathways, and a C-13 magnetic resonance spectroscopic imaging technique to map the spatial distribution of labeled DNA. The study validated eMRI using pigs and discovered regional differences in global DNA methylation. The eMRI signal has the potential to enable new investigations of human brain function, behavior, and disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Catherine G. Tran, Luis C. Borbon, Jacqueline L. Mudd, Ellen Abusada, Solmaz AghaAmiri, Sukhen C. Ghosh, Servando Hernandez Vargas, Guiying Li, Gabriella Beyer, Mary McDonough, Rachel Li, Carlos H. F. Chan, Susan A. Walsh, Thaddeus J. Wadas, Thomas O'Dorisio, M. Sue O'Dorisio, Ramaswamy Govindan, Paul F. Cliften, Ali Azhdarinia, Andrew M. Bellizzi, Ryan C. Fields, James R. Howe, Po Hien Ear
Summary: Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers with increasing incidence. The lack of suitable cellular and animal models for studying and testing new therapies has posed challenges for research on GEP NENs. This study successfully established two PDX models (NEC913 and NEC1452) and demonstrated their utility in drug discovery and research on GEP NENs.
Article
Oncology
Diane S. Abou, Patrick Zerkel, James Robben, Mark McLaughlin, Tim Hazlehurst, David Morse, Thaddeus J. Wadas, Darpan N. Pandya, Reiko Oyama, Gregory Gaehle, Michael L. Nickels, Daniel L. J. Thorek
Summary: The study investigated the impact of Ac-225/Ac-227 material in radiolabeling and quality control evaluation, showing that peptides produced using generator produced Ac-225 can be radiolabeled efficiently. There were subtle but detectable differences in material produced using Ac-225/Ac-227.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Review
Immunology
Amira Zaher, Laura M. Stephens, Ann M. Miller, Stacey M. Hartwig, Jeffrey M. Stolwijk, Michael S. Petronek, Zeb R. Zacharias, Thaddeus J. Wadas, Varun Monga, Joseph J. Cullen, Muhammad Furqan, Jon C. D. Houtman, Steven M. Varga, Douglas R. Spitz, Bryan G. Allen
Summary: Pharmacological ascorbate, with its dual redox roles and immune modulating functions, shows potential as an adjuvant to standard anti-cancer treatments and could enhance the efficacy of immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Pyeong Seok Choi, Jun Young Lee, Jung Ho Chae, Thaddeus Wadas, Zhen Cheng, Min Goo Hur, Jeong Hoon Park
Summary: Cherenkov radiation is being studied for cancer detection and therapy. Nanoparticles are used to develop a theranostic platform for visualizing therapy delivery and generating reactive oxygen species to kill cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Immunology
Anirudh Sattiraju, Sangjo Kang, Bruno Giotti, Zhihong Chen, Valerie J. Marallano, Concetta Brusco, Aarthi Ramakrishnan, Li Shen, Alexander M. Tsankov, Dolores Hambardzumyan, Roland H. Friedel, Hongyan Zou
Summary: This study investigates the immune response and spatial patterning of myeloid cells in glioblastoma. The researchers found that as the tumor progresses, the distribution of tumor-associated myeloid cells changes according to vascular changes. Hypoxic niches attract and sequester these cells, leading to immunosuppression and tumor progression. Understanding these mechanisms could potentially improve treatment options for glioblastoma.
Proceedings Paper
Engineering, Biomedical
Carley G. Stewart, Brieanna Hilkin, Nicholas D. Gansemer, Susan A. Walsh, Michael R. Acevado, Vamsidhar Akurathi, Darpan N. Pandya, Alejandro F. Comellas, Thaddeus J. Wadas, David W. Dick, John J. Sunderland, David A. Stoltz, Michael J. Welsh, Mahmoud H. Abou Alaiwa
Summary: This study aims to develop a measurement assay that accurately quantitates mucociliary transport (MCT) and meets physiological characteristics. By using PET imaging technology, the dynamic process of MCT within the airways was captured, providing precise measurements with high temporal resolution.
2022 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (IEEE ISBI 2022)
(2022)
Article
Multidisciplinary Sciences
Gun Kim, Qiong Wu, James L. Chu, Emily J. Smith, Michael L. Oelze, Jeffrey S. Moore, King C. Li
Summary: This paper reports an in vitro demonstration of a noninvasive cancer therapy using mechanophore embedded in biocompatible hydrogels to generate reactive oxygen species (ROS) under high-intensity focused ultrasound (HIFU) activation, effectively killing tumor cells. This mechanochemical dynamic therapy (MDT) combines the advantages of mechanophores and HIFU to provide a noninvasive treatment for diverse cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Narges K. Tafreshi, HyunJoo Kil, Darpan N. Pandya, Christopher J. Tichacek, Michael L. Doligalski, Mikalai M. Budzevich, Nella C. Delva, Michael L. Langsen, John A. Vallas, David C. Boulware, Robert W. Engelman, Kenneth L. Gage, Eduardo G. Moros, Thaddeus J. Wadas, Mark L. McLaughlin, David L. Morse
Summary: The study investigated the impact of lipophilicity on the biodistribution, pharmacokinetics, toxicity, and radiation dosimetry of a targeted alpha-particle therapy for metastatic melanoma. It was observed that higher lipophilicity led to reduced kidney uptake, absorbed radiation dose, and kidney toxicity, while lower lipophilicity resulted in acute nephropathy and death. Tuning the radiopharmaceutical lipophilicity may help optimize kidney uptake and improve treatment safety and efficacy.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)
Meeting Abstract
Oncology
Anirudh Sattiraju, Valerie Marallano, Aarthi Ramakrishnan, Concetta Brusco, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou