Article
Immunology
Hima Dhakal, Min -Jong Kim, Soyoung Lee, Young-Ae Choi, Namkyung Kim, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: The study demonstrated that ursolic acid (UA) exerts anti-allergic effects by inhibiting FceRI-mediated mast cell activation. It suppresses mast cell degranulation by reducing intracellular calcium levels and inhibits the expression and release of inflammatory cytokines. Furthermore, UA also inhibits passive cutaneous anaphylaxis and active systemic anaphylaxis reactions in a mouse model in a dose-dependent manner.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Donald MacGlashan
Summary: This study found that released FceRI-alpha accounted for 7% of total surface FceRI before the reaction, with a molecular weight of approximately 54 kD. The release of FceRI-alpha was found to be independent of internalized processing and starting density of FceRI, and was more effective with non-IgE-dependent stimuli.
Review
Cell Biology
Xiaopeng Wan, Yuanyuan Zhang, Huanna Tang, Mengyao Li, Tianqi Jiang, Jia He, Chunjing Bao, Junkai Wang, Yinjing Song, Peng Xiao, Yang Liu, Lihua Lai, Qingqing Wang
Summary: IL-27 signaling negatively regulates mast cell activation and allergic response by modulating key signaling pathways and protein phosphorylation levels.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Oncology
Heidi Hempel Sullivan, Janielle P. Maynard, Christopher M. Heaphy, Jiayun Lu, Angelo M. De Marzo, Tamara L. Lotan, Corinne E. Joshu, Karen S. Sfanos
Summary: This study found that higher numbers of tryptase-only mast cells in benign regions of the prostate are associated with an increased risk of biochemical recurrence, metastases, and death from prostate cancer. Further analysis revealed differential expression of specific genes in mast cells between benign and cancer tissue, highlighting the potential role of extra-tumoral mast cells in driving adverse prostate cancer outcomes.
JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Rubi Monserrat Osorio-Perez, Gabriela Rodriguez-Manzo, Zyanya P. Espinosa-Riquer, Silvia L. Cruz, Claudia Gonzalez-Espinosa
Summary: In this review, the regulatory effects of endocannabinoids on the activation of basophils and mast cells are summarized. The presence of the endocannabinoid system and cannabinoid receptors in these cells, as well as their unique signaling characteristics, are emphasized. The interactions between endocannabinoids and FceRI signaling cascades are discussed in detail. Furthermore, important considerations and future perspectives in the study of the effects of endocannabinoids in basophils and mast cells are presented.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Food Science & Technology
Sung-Joon Park, Kyeong Hwa Sim, Prafulla Shrestha, Jae-Ho Yang, Youn Ju Lee
Summary: The study found that PFOS and BPA can induce mast cell-mediated inflammatory responses through a common signaling pathway, increasing the production of inflammatory eicosanoids, leading to skin edema and elevated levels of LTC4 and PGD2 in mice.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Allergy
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frossing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefalt, Celeste Porsbjerg
Summary: This study investigated the relationship between airway hyperresponsiveness and infiltrating mast cells, as well as the effectiveness of inhaled corticosteroid treatment. The results showed that inhaled corticosteroid treatment significantly improved airway hyperresponsiveness in both patients with high fractional exhaled nitric oxide (FENO) and patients with low FENO. However, there were differences in mast cell phenotypes and distribution between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuka Nagata, Yohei Sasaki, Ryo Suzuki
Summary: This study provides further understanding of the anti-allergic effects of the Chinese herb "Mao". It was found that Mao can reduce MC activity and regulate CCL2 expression independently of ephedrine alkaloids.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Allergy
Matthew P. Giannetti, Grace Godwin, Emily Weller, Joseph H. Butterfield, Mariana Castells
Summary: Patients with hereditary alpha-tryptasemia (H alpha T) and symptoms of mast cell activation do not have elevated levels of mast cell urinary metabolites, suggesting that granule- and membrane-derived mediators may not play a role in driving symptoms in H alpha T.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Infectious Diseases
Leonard B. Weinstock, Jill B. Brook, Arthur S. Walters, Ashleigh Goris, Lawrence B. Afrin, Gerhard J. Molderings
Summary: This study found that MCA symptoms were increased in LC patients after COVID-19 and mimicked the symptoms and severity reported by MCAS patients. This suggests that increased activation of aberrant mast cells induced by SARS-CoV-2 infection may underlie part of the pathophysiology of LC.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Allergy
Yuko Kawakami, Miho Kimura, Christella Widjaja, Kazumi Kasakura, Tomoaki Ando, Yu Kawakami, Joshua J. Obar, Toshiaki Kawakami
Summary: This study investigates the relationship between FceRI and RLR-mediated antiviral signaling pathways. Results show that mast cells without the adaptor molecule MAVS exhibit increased cytokine production despite normal degranulation. MAVS inhibits the key signaling molecule Syk kinase, while the deficiency of RIG-I, MDA5, or IRF3 leads to reduced or normal mast cell activation. MAVS-deficient mice show enhanced late-phase responses in passive cutaneous anaphylaxis.
FRONTIERS IN ALLERGY
(2023)
Article
Critical Care Medicine
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung
Summary: By analyzing gene signatures of MC activation, we can identify phenotypes of severe asthma and indicate that MCs can have distinct transcriptional phenotypes associated with specific clinical phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yumi Yamashita, Toshiyuki Yamashita
Summary: Research indicates that there is a preferential dephosphorylation of the Y58 residue following FccRI stimulation, and Y58 is more susceptible to phosphorylation compared to Y47. Additionally, experiments demonstrate that the Src family kinase Lyn phosphorylates Y58 more efficiently than Y47.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Hematology
Kimberly Nellenbach, Alexander Kyu, Nina Guzzetta, Ashley C. Brown
Summary: Neonates have a variant of fibrinogen called fetal fibrinogen with increased sialic acid, greater negative charge, and decreased activity compared to adults. Sialic acid content is a key determinant of clot properties in neonates, influencing fibrin polymerization mechanisms significantly.
Article
Psychology, Multidisciplinary
Chung-hye Han, Keir Moulton, Trevor Block, Holly Gendron, Sander Nederveen
Summary: The study presents results from an eye-tracking experiment in the visual world paradigm, showing that pronouns and reflexives are equally sensitive to structural constraints when placed in the indirect object position following a verb as a recipient argument. This challenges previous findings that suggested a general asymmetry in the processing of pronouns and reflexives in the early stages.
FRONTIERS IN PSYCHOLOGY
(2021)