Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers

Expression of breast cancer stem cell markers as predictors of prognosis and response to trastuzumab in HER2-positive breast cancer

(2016) An Na Seo et al.   BRITISH JOURNAL OF CANCER

The Effect of Electron Beam Irradiation in Environmental Scanning Transmission Electron Microscopy of Whole Cells in Liquid

(2016) Justus Hermannsdörfer et al.   MICROSCOPY AND MICROANALYSIS

HER2 expression identifies dynamic functional states within circulating breast cancer cells

(2016) Nicole Vincent Jordan et al.   NATURE

Single-cell analysis at the threshold

(2016) Xi Chen et al.   NATURE BIOTECHNOLOGY

Biomarkers of residual disease after neoadjuvant therapy for breast cancer

(2016) Frederique Penault-Llorca et al.   Nature Reviews Clinical Oncology

High cell-surface density of HER2 deforms cell membranes

(2016) Inhee Chung et al.   Nature Communications

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy

(2015) Daniel L. Abravanel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell shape and the microenvironment regulate nuclear translocation of NF- B in breast epithelial and tumor cells

(2015) J. E. Sero et al.   Molecular Systems Biology

The influence of subclonal resistance mutations on targeted cancer therapy

(2015) Michael W. Schmitt et al.   Nature Reviews Clinical Oncology

Single-cell analysis tools for drug discovery and development

(2015) James R. Heath et al.   NATURE REVIEWS DRUG DISCOVERY

mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer

(2015) Silvia von der Heyde et al.   PLoS One

Opportunities and challenges in liquid cell electron microscopy

(2015) F. M. Ross   SCIENCE

Trastuzumab resistance induces EMT to transform HER2+ PTEN− to a triple negative breast cancer that requires unique treatment options

(2015) Joseph P. Burnett et al.   Scientific Reports

Local variations of HER2 dimerization in breast cancer cells discovered by correlative fluorescence and liquid electron microscopy

(2015) D. B. Peckys et al.   Science Advances

Challenges in quantitative single molecule localization microscopy

(2014) A. Shivanandan et al.   FEBS LETTERS

The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells

(2014) Sripad Ram et al.   mAbs

Tumour heterogeneity and the evolution of polyclonal drug resistance

(2014) Rebecca A. Burrell et al.   Molecular Oncology

Cryo-scanning transmission electron tomography of vitrified cells

(2014) Sharon Grayer Wolf et al.   NATURE METHODS

Parallel Visualization of Multiple Protein Complexes in Individual Cells in Tumor Tissue

(2013) Karl-Johan Leuchowius et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Epidermal growth factor receptor subunit locations determined in hydrated cells with environmental scanning electron microscopy

(2013) Diana B. Peckys et al.   Scientific Reports

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

(2013) Anton Arkhipov et al.   eLife

Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)

(2012) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Increased hyaluronan content and stromal cell CD44 associate withHER2positivity and poor prognosis in human breast cancer

(2012) Päivi Auvinen et al.   INTERNATIONAL JOURNAL OF CANCER

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Common Protein Biomarkers Assessed by Reverse Phase Protein Arrays Show Considerable Intratumoral Heterogeneity in Breast Cancer Tissues

(2012) Katharina Malinowsky et al.   PLoS One

Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs

(2012) F Henjes et al.   Oncogenesis

Serum starvation: caveat emptor

(2011) Sergej Pirkmajer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers

(2011) R. Ghosh et al.   CANCER RESEARCH

Breast cancer stem cells: treatment resistance and therapeutic opportunities

(2011) Fares Al-Ejeh et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Silicon nitride windows for electron microscopy of whole cells

(2011) E. A. RING et al.   JOURNAL OF MICROSCOPY

Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis

(2011) Prabuddha Sengupta et al.   NATURE METHODS

Electron microscopy of specimens in liquid

(2011) Niels de Jonge et al.   Nature Nanotechnology

Comparing the Epidermal Growth Factor Interaction with Four Different Cell Lines: Intriguing Effects Imply Strong Dependency of Cellular Context

(2011) Hanna Björkelund et al.   PLoS One

Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with 125I-EGF

(2011) Hanna Björkelund et al.   PLoS One

Structural basis for high-affinity HER2 receptor binding by an engineered protein

(2010) C. Eigenbrot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K Inhibition Overcomes Trastuzumab Resistance: Blockade of ErbB2/ErbB3 Is Not Always Enough

(2009) Nancy E. Hynes et al.   CANCER CELL

Electron microscopy of whole cells in liquid with nanometer resolution

(2009) N. d. Jonge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA